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Directed evolution of a model primordial enzyme provides insights into the development of the genetic codeThe human HDV-like CPEB3 ribozyme is intrinsically fast-reactingThe cosmological model of eternal inflation and the transition from chance to biological evolution in the history of lifeAntigenomic delta ribozyme variants with mutations in the catalytic core obtained by the in vitro selection method.RNA conformational changes in the life cycles of RNA viruses, viroids, and virus-associated RNAsOn the origin of life in the Zinc world. 2. Validation of the hypothesis on the photosynthesizing zinc sulfide edifices as cradles of life on EarthA comparison of vanadate to a 2'-5' linkage at the active site of a small ribozyme suggests a role for water in transition-state stabilizationShared traits on the reaction coordinates of ribonuclease and an RNA enzymeStructural effects of nucleobase variations at key active site residue Ade38 in the hairpin ribozymeIdentification of an Imino Group Indispensable for Cleavage by a Small RibozymeCation-dependent cleavage of the duplex form of the subtype-B HIV-1 RNA dimerization initiation siteA Transition-State Interaction Shifts Nucleobase Ionization toward Neutrality To Facilitate Small Ribozyme CatalysisWater in the active site of an all-RNA hairpin ribozyme and effects of Gua8 base variants on the geometry of phosphoryl transferThermodynamic insights into 2-thiouridine-enhanced RNA hybridizationOrigin of hepatitis delta virusA Two-Metal-Ion-Mediated Conformational Switching Pathway for HDV Ribozyme ActivationDesigning artificial enzymes by intuition and computationFunctional nucleic acid sensorsSingle VS ribozyme molecules reveal dynamic and hierarchical folding toward catalysis.Insight into the functional versatility of RNA through model-making with applications to data fitting.On the origin of the translation system and the genetic code in the RNA world by means of natural selection, exaptation, and subfunctionalization.Unwinding the twister ribozyme: from structure to mechanism.Of proteins and RNA: the RNase P/MRP family.Crystal structure studies of RNA duplexes containing s(2)U:A and s(2)U:U base pairsA kinetic and thermodynamic framework for the Azoarcus group I ribozyme reaction.Ribosome-induced tuning of GTP hydrolysis by a translational GTPaseElectrophilic activity-based RNA probes reveal a self-alkylating RNA for RNA labeling.The role of an active site Mg(2+) in HDV ribozyme self-cleavage: insights from QM/MM calculations.Trapped water molecules are essential to structural dynamics and function of a ribozyme.Structure, dynamics, and mechanism of the lead-dependent ribozyme.Evidence for proton transfer in the rate-limiting step of a fast-cleaving Varkud satellite ribozyme.The genomic HDV ribozyme utilizes a previously unnoticed U-turn motif to accomplish fast site-specific catalysisCoupling of fast and slow modes in the reaction pathway of the minimal hammerhead ribozyme cleavage.Multiscale methods for computational RNA enzymology.Functional nucleic acid-based hydrogels for bioanalytical and biomedical applicationsSynthetic RNA circuits.DNA and RNA induced enantioselectivity in chemical synthesis.Coevolution of metabolic networks and membranes: the scenario of progressive sequestration.A general method for constructing atomic-resolution RNA ensembles using NMR residual dipolar couplings: the basis for interhelical motions revealed.Crystal structure of a luteoviral RNA pseudoknot and model for a minimal ribosomal frameshifting motif.
P2860
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P2860
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Ribozyme catalysis: not different, just worse.
@ast
Ribozyme catalysis: not different, just worse.
@en
type
label
Ribozyme catalysis: not different, just worse.
@ast
Ribozyme catalysis: not different, just worse.
@en
prefLabel
Ribozyme catalysis: not different, just worse.
@ast
Ribozyme catalysis: not different, just worse.
@en
P2860
P356
P1476
Ribozyme catalysis: not different, just worse.
@en
P2860
P2888
P304
P356
10.1038/NSMB932
P577
2005-05-01T00:00:00Z
P5875
P6179
1041571163