Tissue specific expression of the human alpha-1-antitrypsin gene in transgenic mice.
about
Evolution of murine alpha 1-proteinase inhibitors: gene amplification and reactive center divergenceBarriers to inhaled gene therapy of obstructive lung diseases: A reviewDifferential regulation of gene activity and chromatin structure within the human serpin gene cluster at 14q32.1 in macrophage microcell hybrids.Stable expression and cell-specific chromatin structure of human alpha1-antitrypsin cosmid transgenes in rat hepatoma cells.Cis- and trans-acting elements responsible for the cell-specific expression of the human alpha 1-antitrypsin geneCharacterization of recombinant human factor IX expressed in transgenic mice and in derived trans-immortalized hepatic cell lines.Multiple tissues express alpha 1-antitrypsin in transgenic mice and man.Accumulation of PiZ alpha 1-antitrypsin causes liver damage in transgenic mice.Interferon beta 2/interleukin 6 modulates synthesis of alpha 1-antitrypsin in human mononuclear phagocytes and in human hepatoma cells.The human alpha-1-antitrypsin gene is efficiently expressed from two tissue-specific promotors in transgenic miceSpontaneous hepatic repopulation in transgenic mice expressing mutant human α1-antitrypsin by wild-type donor hepatocytesChromosomal elements regulate gene activity and chromatin structure of the human serpin gene cluster at 14q32.1.Disruption of the LF-A1 and LF-B1 binding sites in the human alpha-1-antitrypsin gene has a differential effect during development in transgenic mice.Negative and positive cis-acting elements control the expression of murine alpha 1-protease inhibitor genesHighly conserved upstream regions of the alpha 1-antitrypsin gene in two mouse species govern liver-specific expression by different mechanisms.Isolation and identification of cell-specific microRNAs targeting a messenger RNA using a biotinylated anti-sense oligonucleotide capture affinity techniqueMolecular basis for defective secretion of the Z variant of human alpha-1-proteinase inhibitor: secretion of variants having altered potential for salt bridge formation between amino acids 290 and 342.Hepatitis B virus transactivator X protein is not tumorigenic in transgenic miceMultiple hepatic trans-acting factors are required for in vitro transcription of the human alpha-1-antitrypsin gene.Sustained knockdown of a disease-causing gene in patient-specific induced pluripotent stem cells using lentiviral vector-based gene therapy.The mammalian UPR boosts glycoprotein ERAD by suppressing the proteolytic downregulation of ER mannosidase I.Vascular damage without hypertension in transgenic rats expressing prorenin exclusively in the liver.Mouse hepatocytes migrate to liver parenchyma and function indefinitely after intrasplenic transplantation.Antisense oligonucleotide treatment ameliorates alpha-1 antitrypsin-related liver disease in mice.Bile Duct Ligation Induces ATZ Globule Clearance in a Mouse Model of α-1 Antitrypsin Deficiency.Mysteries of α1-antitrypsin deficiency: emerging therapeutic strategies for a challenging disease.Intracellular disposal of incompletely folded human alpha1-antitrypsin involves release from calnexin and post-translational trimming of asparagine-linked oligosaccharides.Alpha-1-antitrypsin deficiency: accumulation or degradation of mutant variants within the hepatic endoplasmic reticulum.Tissue-specific expression of the human alpha 1-antitrypsin gene is controlled by multiple cis-regulatory elements.Human Urinary Epithelial Cells as a Source of Engraftable Hepatocyte-Like Cells Using Stem Cell Technology.Sustained miRNA-mediated knockdown of mutant AAT with simultaneous augmentation of wild-type AAT has minimal effect on global liver miRNA profiles.Knockdown of Z Mutant Alpha-1 Antitrypsin In Vivo Using Modified DNA Antisense Oligonucleotides.Alpha-1-antitrypsin deficiency: from genoma to liver disease. PiZ mouse as model for the development of liver pathology in human.
P2860
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P2860
Tissue specific expression of the human alpha-1-antitrypsin gene in transgenic mice.
description
1987 nî lūn-bûn
@nan
1987年の論文
@ja
1987年論文
@yue
1987年論文
@zh-hant
1987年論文
@zh-hk
1987年論文
@zh-mo
1987年論文
@zh-tw
1987年论文
@wuu
1987年论文
@zh
1987年论文
@zh-cn
name
Tissue specific expression of the human alpha-1-antitrypsin gene in transgenic mice.
@ast
Tissue specific expression of the human alpha-1-antitrypsin gene in transgenic mice.
@en
type
label
Tissue specific expression of the human alpha-1-antitrypsin gene in transgenic mice.
@ast
Tissue specific expression of the human alpha-1-antitrypsin gene in transgenic mice.
@en
prefLabel
Tissue specific expression of the human alpha-1-antitrypsin gene in transgenic mice.
@ast
Tissue specific expression of the human alpha-1-antitrypsin gene in transgenic mice.
@en
P2093
P2860
P356
P1476
Tissue specific expression of the human alpha-1-antitrypsin gene in transgenic mice.
@en
P2093
P2860
P304
P356
10.1093/NAR/15.4.1459
P407
P577
1987-02-01T00:00:00Z