MRE11 deficiency increases sensitivity to poly(ADP-ribose) polymerase inhibition in microsatellite unstable colorectal cancers - Wikidata - awgldk - TriplyDB

MRE11 deficiency increases sensitivity to poly(ADP-ribose) polymerase inhibition in microsatellite unstable colorectal cancers

MRE11 deficiency increases sensitivity to poly(ADP-ribose) polymerase inhibition in microsatellite unstable colorectal cancers

http://www.wikidata.org/entity/Q36123830

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Trial watch - inhibiting PARP enzymes for anticancer therapy Nucleases in homologous recombination as targets for cancer therapy Beyond Breast and Ovarian Cancers: PARP Inhibitors for BRCA Mutation-Associated and BRCA-Like Solid Tumors The role of PARP in DNA repair and its therapeutic exploitation Low ATM protein expression and depletion of p53 correlates with olaparib sensitivity in gastric cancer cell lines.Effect of MRE11 loss on PARP-inhibitor sensitivity in endometrial cancer in vitro Combinations of PARP Inhibitors with Temozolomide Drive PARP1 Trapping and Apoptosis in Ewing's Sarcoma PARP1 expression drives the synergistic antitumor activity of trabectedin and PARP1 inhibitors in sarcoma preclinical models.Strategies for the Use of Poly(adenosine diphosphate ribose) Polymerase (PARP) Inhibitors in Cancer Therapy.The PARP inhibitors, veliparib and olaparib, are effective chemopreventive agents for delaying mammary tumor development in BRCA1-deficient mice XRCC2 rs3218536 polymorphism decreases the sensitivity of colorectal cancer cells to poly(ADP-ribose) polymerase 1 inhibitor.Mismatch repair deficiency endows tumors with a unique mutation signature and sensitivity to DNA double-strand breaks.Development of synthetic lethality anticancer therapeutics.Synthetic lethality of PARP inhibition in cancers lacking BRCA1 and BRCA2 mutations.Gene expression differences between colon and rectum tumors XI-006 induces potent p53-independent apoptosis in Ewing sarcoma.Meta-analysis of organ-specific differences in the structure of the immune infiltrate in major malignancies.Molecular pathways: microsatellite instability in colorectal cancer: prognostic, predictive, and therapeutic implications Development of a multiparameter flow cytometric assay as a potential biomarker for homologous recombination deficiency in women with high-grade serous ovarian cancer.Differential effects of poly(ADP-ribose) polymerase inhibition on DNA break repair in human cells are revealed with Epstein-Barr virus CpG Island Methylation, Microsatellite Instability, and BRAF Mutations and Their Clinical Application in the Treatment of Colon Cancer.Multigene panel analysis identified germline mutations of DNA repair genes in breast and ovarian cancer.Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition.XRCC2 promotes colorectal cancer cell growth, regulates cell cycle progression, and apoptosis Cross-platform pathway-based analysis identifies markers of response to the PARP inhibitor olaparib.Combined olaparib and oxaliplatin inhibits tumor proliferation and induces G2/M arrest and γ-H2AX foci formation in colorectal cancer.Lack of MRE11-RAD50-NBS1 (MRN) complex detection occurs frequently in low-grade epithelial ovarian cancer.Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes.Predicting PARP inhibitor sensitivity and resistance.WISP3 is highly expressed in a subset of colorectal carcinomas with a better prognosis.XRCC2 as a predictive biomarker for radioresistance in locally advanced rectal cancer patients undergoing preoperative radiotherapy.Phase II Study of Olaparib (AZD-2281) After Standard Systemic Therapies for Disseminated Colorectal Cancer Saccharomyces cerevisiae genetics predicts candidate therapeutic genetic interactions at the mammalian replication fork.PARP inhibition selectively increases sensitivity to cisplatin in ERCC1-low non-small cell lung cancer cells.Molecular dissection of microsatellite instable colorectal cancer MicroRNA polymorphisms and risk of colorectal cancer Epithelial but not stromal expression of collagen alpha-1(III) is a diagnostic and prognostic indicator of colorectal carcinoma.Genomic leftovers: identifying novel microsatellites, over-represented motifs and functional elements in the human genome.Polyisoprenylated methylated protein methyl esterase is both sensitive to curcumin and overexpressed in colorectal cancer: implications for chemoprevention and treatment.DNA damage tolerance: a double-edged sword guarding the genome

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P2860

MRE11 deficiency increases sensitivity to poly(ADP-ribose) polymerase inhibition in microsatellite unstable colorectal cancers

http://www.wikidata.org/entity/Q36123830

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name

MRE11 deficiency increases sen ...... te unstable colorectal cancers

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MRE11 deficiency increases sen ...... te unstable colorectal cancers

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MRE11 deficiency increases sen ...... te unstable colorectal cancers

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Cancer Research

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Bhramar Mukherjee

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Catherine M Bartnik

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Jaeil Ahn

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Leon Raskin

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Maria D Iniesta

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P2860

Bioconductor: open software development for computational biology and bioinformatics

DNA Damage, Aging, and Cancer

Epigenetic silencing of AXIN2 in colorectal carcinoma with microsatellite instability

Colorectal cancers with microsatellite instability display mRNA expression signatures characteristic of increased immunogenicity.

Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers.

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

A comparison of normalization methods for high density oligonucleotide array data based on variance and bias

Exploration, normalization, and summaries of high density oligonucleotide array probe level data

Statins and the risk of colorectal cancer

Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks

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