Drug insight: Testosterone and selective androgen receptor modulators as anabolic therapies for chronic illness and aging - Wikidata - awgldk - TriplyDB

Drug insight: Testosterone and selective androgen receptor modulators as anabolic therapies for chronic illness and aging

Drug insight: Testosterone and selective androgen receptor modulators as anabolic therapies for chronic illness and aging

http://www.wikidata.org/entity/Q36130944

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Sarcopenia and age-related endocrine function The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men Pharmacology of anabolic steroids The aging male hypothalamic-pituitary-gonadal axis: pulsatility and feedback Effect of B-ring substitution pattern on binding mode of propionamide selective androgen receptor modulators Testosterone treatment comes of age: new options for hypogonadal men Identification of a Novel Coregulator, SH3YL1, That Interacts With the Androgen Receptor N-Terminus.Adverse health consequences of performance-enhancing drugs: an Endocrine Society scientific statement.Effects of graded doses of testosterone on erythropoiesis in healthy young and older men.Effects of a supraphysiological dose of testosterone on physical function, muscle performance, mood, and fatigue in men with HIV-associated weight loss.Testosterone supplementation reverses sarcopenia in aging through regulation of myostatin, c-Jun NH2-terminal kinase, Notch, and Akt signaling pathways.Therapies for musculoskeletal disease: can we treat two birds with one stone?Translational studies in older men using testosterone to treat sarcopenia.Selective androgen receptor modulators as function promoting therapies.The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double-blind, placebo-controlled phase II trial.Effects of long term supplementation of anabolic androgen steroids on human skeletal muscle.Characterization of GLPG0492, a selective androgen receptor modulator, in a mouse model of hindlimb immobilization Androgen receptor roles in insulin resistance and obesity in males: the linkage of androgen-deprivation therapy to metabolic syndrome Hormone treatment and muscle anabolism during aging: androgens.Dihydrotestosterone ameliorates degeneration in muscle, axons and motoneurons and improves motor function in amyotrophic lateral sclerosis model mice.[Glucocorticoids and androgens for treatment of tiredness and weakness in palliative care patients : a systematic review].Effects of transdermal testosterone on bone and muscle in older men with low bioavailable testosterone levels, low bone mass, and physical frailty.Testosterone Supplementation Improves Carbohydrate and Lipid Metabolism in Some Older Men with Abdominal Obesity.Testosterone threshold levels and lean tissue mass targets needed to enhance skeletal muscle strength and function: the HORMA trial.The role of GH and IGF-I in mediating anabolic effects of testosterone on androgen-responsive muscle Skeletal myopathy in patients with chronic heart failure: significance of anabolic-androgenic hormones Endocrinology of the aging male.Combined administration of testosterone plus an ornithine decarboxylase inhibitor as a selective prostate-sparing anabolic therapy.Identification of serum biomarkers for aging and anabolic response Clinical meaningfulness of the changes in muscle performance and physical function associated with testosterone administration in older men with mobility limitation Diagnosis and Treatment of Low Testosterone among Patients with End-Stage Renal Disease.Hypogonadism in the aging male diagnosis, potential benefits, and risks of testosterone replacement therapy.Sarcopenia and cachexia: the adaptations of negative regulators of skeletal muscle mass.Pathogenesis of muscle wasting in cancer cachexia: targeted anabolic and anticatabolic therapies.Recommendations on the diagnosis, treatment and monitoring of hypogonadism in men.Mouse model of testosterone-induced muscle fiber hypertrophy: involvement of p38 mitogen-activated protein kinase-mediated Notch signaling Neuronal androgen receptor regulates insulin sensitivity via suppression of hypothalamic NF-κB-mediated PTP1B expression.Effects of testosterone and progressive resistance exercise in healthy, highly functioning older men with low-normal testosterone levels.Changes in muscle mass, muscle strength, and power but not physical function are related to testosterone dose in healthy older men.Effects of enobosarm on muscle wasting and physical function in patients with cancer: a double-blind, randomised controlled phase 2 trial

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Drug insight: Testosterone and selective androgen receptor modulators as anabolic therapies for chronic illness and aging

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Nature Clinical Practice Endocrinology and Metabolism

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Drug insight: Testosterone and ...... for chronic illness and aging

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Martin L Lee

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Norman A Mazer

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Olga M Calof

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Ravi Jasuja

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Thomas W Storer

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Wenqing Gao

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P2860

Structural basis for antagonism and resistance of bicalutamide in prostate cancer

Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs

Principles for modulation of the nuclear receptor superfamily

Pharmacological uncoupling of androgen receptor-mediated prostate cancer cell proliferation and prostate-specific antigen secretion.

Interrelationships among lipoprotein levels, sex hormones, anthropometric parameters, and age in hypogonadal men treated for 1 year with a permeation-enhanced testosterone transdermal system.

Distinguishing androgen receptor agonists and antagonists: distinct mechanisms of activation by medroxyprogesterone acetate and dihydrotestosterone.

Effects of transdermal testosterone on bone and muscle in older men with low bioavailable testosterone levels.

Testosterone dose-response relationships in healthy young men.

Androgens stimulate myogenic differentiation and inhibit adipogenesis in C3H 10T1/2 pluripotent cells through an androgen receptor-mediated pathway.

The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men.

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146-159

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10.1038/NCPENDMET0120

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3

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2

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Shalender Bhasin

Victor M. Montori

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6856669

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16932274

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2072878

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