about
Antibiotic inducibility of the MexXY multidrug efflux system of Pseudomonas aeruginosa: involvement of the antibiotic-inducible PA5471 gene productCrystal structures of complexes between aminoglycosides and decoding A site oligonucleotides: role of the number of rings and positive charges in the specific binding leading to miscodingSmall molecules targeting viral RNATherapeutic suppression of premature termination codons: mechanisms and clinical considerations (review)Conformational inhibition of the hepatitis C virus internal ribosome entry site RNAStructural basis for hygromycin B inhibition of protein biosynthesisA model for the study of ligand binding to the ribosomal RNA helix h44From Erythromycin to Azithromycin and New Potential Ribosome-Binding Antimicrobials.The bacterial ribosome as a target for antibioticsPrincipal component and clustering analysis on molecular dynamics data of the ribosomal L11·23S subdomainSearch for novel aminoglycosides by combining fragment-based virtual screening and 3D-QSAR scoringSelection of small peptides, inhibitors of translation.1,3-Diazepanes of natural product-like complexity from cyanamide-induced rearrangement of epoxy-delta-lactams.Discovery and analysis of 4H-pyridopyrimidines, a class of selective bacterial protein synthesis inhibitors.Characterization of the TDP-D-ravidosamine biosynthetic pathway: one-pot enzymatic synthesis of TDP-D-ravidosamine from thymidine-5-phosphate and glucose-1-phosphate.Structure-guided discovery of novel aminoglycoside mimetics as antibacterial translation inhibitorsIdentification of biologically active, HIV TAR RNA-binding small molecules using small molecule microarrays.Characterization of TDP-4-keto-6-deoxy-D-glucose-3,4-ketoisomerase from the D-mycaminose biosynthetic pathway of Streptomyces fradiae: in vitro activity and substrate specificity studiesHIV-1 drug discovery: targeting folded RNA structures with branched peptides.Structure of a hepatitis C virus RNA domain in complex with a translation inhibitor reveals a binding mode reminiscent of riboswitchesDiscovery and Analysis of Natural-Product Compounds Inhibiting Protein Synthesis in Pseudomonas aeruginosa.Engineering the rRNA decoding site of eukaryotic cytosolic ribosomes in bacteriaCisplatin Targeting of Bacterial Ribosomal RNA Hairpins.A modular approach to synthetic RNA binders of the hepatitis C virus internal ribosome entry site.Direct observation of aminoglycoside-RNA binding by localized surface plasmon resonance spectroscopy.Multivalent Amino Sugars to Recognize Different TAR RNA Conformations.Designer aminoglycosides: the race to develop improved antibiotics and compounds for the treatment of human genetic diseases.Screening for inhibitors of the hepatitis C virus internal ribosome entry site RNA.An approach to the construction of tailor-made amphiphilic peptides that strongly and selectively bind to hairpin RNA targets.Influence of dimethylsulfoxide on RNA structure and ligand binding.Antibiotics from microbes: converging to kill.A Numbers Game: Ribosome Densities, Bacterial Growth, and Antibiotic-Mediated Stasis and Death.A yeast-based assay identifies drugs that interfere with immune evasion of the Epstein-Barr virus.Simulating activity of the bacterial ribosome.Informatics, machine learning and computational medicinal chemistry.Visualization of bionanostructures using transmission electron microscopical techniques.Themes and variations in riboswitch structure and function.Analysis of ribosomal inter-subunit sites as targets for complementary oligonucleotides.A peptide nucleic acid-aminosugar conjugate targeting transactivation response element of HIV-1 RNA genome shows a high bioavailability in human cells and strongly inhibits tat-mediated transactivation of HIV-1 transcriptionThe Emerging Role of RNA as a Therapeutic Target for Small Molecules.
P2860
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P2860
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Drugs targeting the ribosome.
@ast
Drugs targeting the ribosome.
@en
type
label
Drugs targeting the ribosome.
@ast
Drugs targeting the ribosome.
@en
prefLabel
Drugs targeting the ribosome.
@ast
Drugs targeting the ribosome.
@en
P1476
Drugs targeting the ribosome.
@en
P2093
Thomas Hermann
P304
P356
10.1016/J.SBI.2005.05.001
P577
2005-06-01T00:00:00Z