Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases.
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A novel small molecule hydroxamate preferentially inhibits HDAC6 activity and tumour growthStructural and functional analysis of the human HDAC4 catalytic domain reveals a regulatory structural zinc-binding domainHistone deacetylase 3 localizes to the mitotic spindle and is required for kinetochore-microtubule attachment.Histone deacetylase signaling in cardioprotectionHistone deacetylase (HDAC) inhibitors attenuate cardiac hypertrophy by suppressing autophagyReduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosisTasquinimod Is an Allosteric Modulator of HDAC4 survival signaling within the compromised cancer microenvironmentThe many roles of histone deacetylases in development and physiology: implications for disease and therapyEpigenetic Mechanisms in Developmental Alcohol-Induced Neurobehavioral DeficitsHistone deacetylases in monocyte/macrophage development, activation and metabolism: refining HDAC targets for inflammatory and infectious diseasesMEF2 transcription factors: developmental regulators and emerging cancer genesMetabolic reprogramming by class I and II histone deacetylasesHDAC signaling in neuronal development and axon regenerationHDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs?Loss of the putative catalytic domain of HDAC4 leads to reduced thermal nociception and seizures while allowing normal bone developmentInsulin and mTOR Pathway Regulate HDAC3-Mediated Deacetylation and Activation of PGK1Human HDAC7 Harbors a Class IIa Histone Deacetylase-specific Zinc Binding Motif and Cryptic Deacetylase ActivitySelective class IIa histone deacetylase inhibition via a nonchelating zinc-binding groupIdentification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparumAberrant Expression of Histone Deacetylases 4 in Cognitive Disorders: Molecular Mechanisms and a Potential TargetDysregulation of Acetylation Enzymes Inanimal Models of Psychostimulant use Disorders: Evolving StoriesProfiling technologies for the identification and characterization of small-molecule histone deacetylase inhibitorsEmerging roles for histone deacetylases in pulmonary hypertension and right ventricular remodeling (2013 Grover Conference series)Acetyl-lysine erasers and readers in the control of pulmonary hypertension and right ventricular hypertrophyPost-translational modifications regulate class IIa histone deacetylase (HDAC) function in health and diseaseHDAC4 does not act as a protein deacetylase in the postnatal murine brain in vivoDifferential effects of binge methamphetamine injections on the mRNA expression of histone deacetylases (HDACs) in the rat striatumHDAC4 and PCAF bind to cardiac sarcomeres and play a role in regulating myofilament contractile activityHistone deacetylase inhibitors for cancer therapy: An evolutionarily ancient resistance response may explain their limited successThe Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and menHDAC3-dependent reversible lysine acetylation of cardiac myosin heavy chain isoforms modulates their enzymatic and motor activityInhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease.A conserved histone deacetylase with a role in the regulation of cytokinesis in Schizosaccharomyces pombe.MEF2 is a converging hub for histone deacetylase 4 and phosphatidylinositol 3-kinase/Akt-induced transformation.Chemical phylogenetics of histone deacetylases.Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha3beta-tetrapeptides.Vorinostat-like molecules as structural, stereochemical, and pharmacological toolsFrom neural development to cognition: unexpected roles for chromatin.Histone H4 deacetylation plays a critical role in early gene silencing during neuronal apoptosisSpecific activity of class II histone deacetylases in human breast cancer cells
P2860
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P2860
Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases.
@ast
Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases.
@en
type
label
Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases.
@ast
Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases.
@en
prefLabel
Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases.
@ast
Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases.
@en
P2093
P2860
P356
P1476
Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases.
@en
P2093
C Steinkühler
M J Bottomley
M Pallaoro
P Gallinari
P Lo Surdo
P2860
P304
17335-17340
P356
10.1073/PNAS.0706487104
P407
P577
2007-10-23T00:00:00Z