Intrathecal IgM production at clinical onset correlates with a more severe disease course in multiple sclerosis - Wikidata - awgldk - TriplyDB

Intrathecal IgM production at clinical onset correlates with a more severe disease course in multiple sclerosis

Intrathecal IgM production at clinical onset correlates with a more severe disease course in multiple sclerosis

http://www.wikidata.org/entity/Q36142794

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Atacicept: targeting B cells in multiple sclerosis Hypersensitivity Responses in the Central Nervous System DRB1*03:01 haplotypes: differential contribution to multiple sclerosis risk and specific association with the presence of intrathecal IgM bands.Serum autoantibodies to myelin peptides distinguish acute disseminated encephalomyelitis from relapsing-remitting multiple sclerosis.What makes a prognostic biomarker in CNS diseases: strategies for targeted biomarker discovery? Part 2: chronic progressive and relapsing disease.Oligoclonal bands in multiple sclerosis patients: worse prognosis?Intrathecal synthesis of IgM measured after a first demyelinating event suggestive of multiple sclerosis is associated with subsequent MRI brain lesion accrual.The association of intrathecal immunoglobulin synthesis and cortical lesions predicts disease activity in clinically isolated syndrome and early relapsing-remitting multiple sclerosis.Lipid-specific immunoglobulin M in CSF predicts adverse long-term outcome in multiple sclerosis.

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P2860

Intrathecal IgM production at clinical onset correlates with a more severe disease course in multiple sclerosis

http://www.wikidata.org/entity/Q36142794

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Journal of Neurology, Neurosurgery and Psychiatry

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Intrathecal IgM production at ...... e course in multiple sclerosis

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Battistin L

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Calabrese M

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Gallo P

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Perini P

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Ranzato F

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P2860

Origins and functions of B-1 cells with notes on the role of CD5

Intrathecal synthesis of oligoclonal IgM against myelin lipids predicts an aggressive disease course in MS.

Heterogeneity of multiple sclerosis pathogenesis: implications for diagnosis and therapy.

Neuropathology of multiple sclerosis-new concepts.

Temporal invariance and clonal uniformity of brain and cerebrospinal IgG, IgA, and IgM in multiple sclerosis.

Recapitulation of B cell differentiation in the central nervous system of patients with multiple sclerosis.

B cells expressing CD5 are increased in cerebrospinal fluid of patients with multiple sclerosis.

CSF myelin basic protein, IgG and IgM levels in 101 MS patients before and after treatment with high-dose intravenous methylprednisolone.

Intrathecal IgM synthesis predicts the onset of new relapses and a worse disease course in MS.

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10.1136/JNNP.2005.086116

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multiple sclerosis

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