Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachone - Wikidata - awgldk - TriplyDB

Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachone

Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachone

http://www.wikidata.org/entity/Q36146939

about

Metabolic Imaging to Assess Treatment Response to Cytotoxic and Cytostatic Agents Hydrogen peroxide inhibition of bicupin oxalate oxidase.From Krebs to clinic: glutamine metabolism to cancer therapy.Pioglitazone-mediated reversal of elevated glucose metabolism in the airway epithelium of mouse lung adenocarcinomas.Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism Glutaminase inhibitor compound 968 inhibits cell proliferation and sensitizes paclitaxel in ovarian cancer Autophagy is required for PDAC glutamine metabolism.Structural basis for exploring the allosteric inhibition of human kidney type glutaminase.Dysregulation of signaling pathways associated with innate antibacterial immunity in patients with pancreatic cancer.Tumor-associated mutant p53 promotes cancer cell survival upon glutamine deprivation through p21 induction.Genome-scale modeling of NADPH-driven β-lapachone sensitization in head and neck squamous cell carcinoma.Synthesis, characterization and antineoplastic activity of bis-aziridinyl dimeric naphthoquinone - A novel class of compounds with potent activity against acute myeloid leukemia cells.Blockage of glutaminolysis enhances the sensitivity of ovarian cancer cells to PI3K/mTOR inhibition involvement of STAT3 signaling.Computational Model Predicts the Effects of Targeting Cellular Metabolism in Pancreatic Cancer.Biological determinants of radioresistance and their remediation in pancreatic cancer.Glutamine Metabolism in Cancer: Understanding the Heterogeneity.Metabolic reprogramming in clear cell renal cell carcinoma.Glutaminase inhibitor CB-839 synergizes with carfilzomib in resistant multiple myeloma cells.Glutaminase and poly(ADP-ribose) polymerase inhibitors suppress pyrimidine synthesis and VHL-deficient renal cancers.Press-pulse: a novel therapeutic strategy for the metabolic management of cancer.The NQO1 bioactivatable drug, β-lapachone, alters the redox state of NQO1+ pancreatic cancer cells, causing perturbation in central carbon metabolism.Enhancing Oral Absorption of β-Lapachone: Progress Till Date.Down-expression of poly(ADP-ribose) polymerase in p53-regulated pancreatic cancer cells.The critical roles of activated stellate cells-mediated paracrine signaling, metabolism and onco-immunology in pancreatic ductal adenocarcinoma.Mitochondrial glutamine metabolism via GOT2 supports pancreatic cancer growth through senescence inhibition.Inhibition of glutamate oxaloacetate transaminase 1 in cancer cell lines results in altered metabolism with increased dependency of glucose.Pancreatic Cancer: Molecular Characterization, Clonal Evolution and Cancer Stem Cells.

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Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachone

http://www.wikidata.org/entity/Q36146939

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2015年の論文

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2015年論文

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2015年论文

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2015年论文

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Targeting glutamine metabolism ...... strophe induced by ß-lapachone

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Cancer & Metabolism

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Targeting glutamine metabolism ...... strophe induced by ß-lapachone

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Aktar Ali

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Alec C Kimmelman

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Costas A Lyssiotis

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David A Boothman

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Gaurab Chakrabarti

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Lewis C Cantley

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Mahesh Padanad

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Mariya Ilcheva

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Pier P Scaglioni

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Ralph J DeBerardinis

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P2860

Hallmarks of Cancer: The Next Generation

Modulating endogenous NQO1 levels identifies key regulatory mechanisms of action of β-lapachone for pancreatic cancer therapy.

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells

Pancreatic cancer

Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

Tumor-selective, futile redox cycle-induced bystander effects elicited by NQO1 bioactivatable radiosensitizing drugs in triple-negative breast cancers.

Capturing the metabolomic diversity of KRAS mutants in non-small-cell lung cancer cells.

DPEP1 inhibits tumor cell invasiveness, enhances chemosensitivity and predicts clinical outcome in pancreatic ductal adenocarcinoma

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