The fast release of sticky protons: kinetics of substrate binding and proton release in a multidrug transporter
about
Analyzing conformational changes in the transport cycle of EmrEStructures of a Na+-coupled, substrate-bound MATE multidrug transporterStructural insights into H+-coupled multidrug extrusion by a MATE transporterProtonation of a glutamate residue modulates the dynamics of the drug transporter EmrECompetition as a way of life for H(+)-coupled antiportersIntrinsic conformational plasticity of native EmrE provides a pathway for multidrug resistanceEmrE dimerization depends on membrane environment.Topologically random insertion of EmrE supports a pathway for evolution of inverted repeats in ion-coupled transportersAntiparallel EmrE exports drugs by exchanging between asymmetric structuresStructure and mechanism of RND-type multidrug efflux pumpsTransforming a drug/H+ antiporter into a polyamine importer by a single mutation.Engineering of a CPC acylase using a facile pH indicator assay.Synergistic substrate binding determines the stoichiometry of transport of a prokaryotic H(+)/Cl(-) exchanger.Undecided membrane proteins insert in random topologies. Up, down and sideways: it does not really matterAsymmetric protonation of EmrE.Perplexing new insight into the dynamics of the EmrE transporter.Role of protons in sugar binding to LacYParallel topology of genetically fused EmrE homodimers.New substrates on the block: clinically relevant resistances for EmrE and homologues.Intracellular proton regulation of ClC-0Identification of molecular hinge points mediating alternating access in the vesicular monoamine transporter VMAT2.Transported substrate determines exchange rate in the multidrug resistance transporter EmrE.Residues in the H+ translocation site define the pKa for sugar binding to LacY.Structural and mechanistic diversity of multidrug transporters.Identification of a glycine motif required for packing in EmrE, a multidrug transporter from Escherichia coli.Dissection of mechanistic principles of a secondary multidrug efflux protein.New free-exchange model of EmrE transport.A mass spectrometry based transport assay for studying EmrE transport of unlabeled substrates.
P2860
Q26829989-DBA17C82-3BFB-4B79-81C0-163812F589A8Q27675964-0741795E-D494-47D0-A689-4CF6C10BB6ADQ27680402-79400531-53C2-44B7-8D5C-A2E71927CF40Q28604217-B62FA4C0-A452-4849-A36A-EE26DCEBA674Q28657397-900F2F42-829C-4672-9F2A-D5E63F069F1BQ28657903-08EB8BEC-CE7C-4652-8126-03BE732FDB4EQ33771551-0751BC28-B9BB-440E-97F4-183B9C758E88Q33832720-18BB1FF0-4B62-49F3-B7D7-3B05E9D6515BQ34104584-EBA3BE50-B727-478F-A185-F3CAEEB5861DQ34194314-F81EFBC9-30E5-4383-8E1D-C8913D177938Q34433319-17DED38D-201C-4BAD-ADA2-303122E200D0Q35251122-58073855-89D2-49B6-87EE-811433C48F5FQ35947311-6C2BC9BC-3C11-4264-88AC-CFB38FEA51F6Q36024435-C49EDB86-2F5C-49A8-9EC6-B08C5BA34DBAQ36333191-0585C436-4B1D-4966-8B38-9F1F74C8A2BDQ36333218-13BFBD51-5205-4F18-BDB4-CD84E1050542Q36342663-E0E065AB-1777-41FA-A78A-D0F268620D20Q36391998-2EE8CD5D-050C-43EB-8D2E-335635922533Q36435302-B5E4EA30-B2DA-4E27-8FA4-64294C1C44A0Q36741175-8EDCDF58-8225-4013-960E-139973510465Q36762583-B523E15F-630D-4EE5-8BB5-85AD547221A6Q37622600-45A8BABF-29F5-47F4-84E5-9EA8B4348406Q38351323-4F40218F-E7AA-4539-BBA1-4861EEDCB154Q38912551-D184182F-40B5-4FCC-95ED-17CDC024B964Q39259841-9BA657D8-EA14-408C-87BF-2C58CB283C16Q41107316-39C703D4-6094-4263-A69C-5C636F3843F1Q47428532-5C331C5B-DA04-4CFE-9392-3DC4C26CE536Q54252382-C8AB8E00-8644-43B4-AB6F-3EE16B763C05
P2860
The fast release of sticky protons: kinetics of substrate binding and proton release in a multidrug transporter
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
The fast release of sticky pro ...... ase in a multidrug transporter
@ast
The fast release of sticky pro ...... ase in a multidrug transporter
@en
type
label
The fast release of sticky pro ...... ase in a multidrug transporter
@ast
The fast release of sticky pro ...... ase in a multidrug transporter
@en
prefLabel
The fast release of sticky pro ...... ase in a multidrug transporter
@ast
The fast release of sticky pro ...... ase in a multidrug transporter
@en
P2093
P2860
P356
P1476
The fast release of sticky pro ...... ase in a multidrug transporter
@en
P2093
Dvir Rotem
Gideon Schreiber
Naama Tayer
P2860
P304
17989-17994
P356
10.1073/PNAS.0704425104
P407
P577
2007-11-02T00:00:00Z