Drug resistance in epilepsy: putative neurobiologic and clinical mechanisms.
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Mutation I810N in the alpha3 isoform of Na+,K+-ATPase causes impairments in the sodium pump and hyperexcitability in the CNS.A conceptual framework for the use of neuroimaging to study and predict pharmacoresistance in epilepsyPharmacoresistant epilepsy: unmet needs in solving the puzzle(s)Modern antiepileptic drug development has failed to deliver: ways out of the current dilemma.Managing drug-resistant epilepsy: challenges and solutionsUnique behavioral characteristics and microRNA signatures in a drug resistant epilepsy modeleEF-2 Phosphorylation Down-Regulates P-Glycoprotein Over-Expression in Rat Brain Microvessel Endothelial CellsLack of support for a role for RLIP76 (RALBP1) in response to treatment or predisposition to epilepsy.Pursuing paradoxical proconvulsant prophylaxis for epileptogenesisAstrocyte-neuronal interactions in epileptogenesis.(R)-[11C]verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus.Long-term control of epileptic drop attacks with the combination of valproate, lamotrigine, and a benzodiazepine: a 'proof of concept,' open label study.Difficulties in Treatment and Management of Epilepsy and Challenges in New Drug DevelopmentNeuroimaging predictors of AED resistance in new-onset epilepsies.Coffee and its consumption: benefits and risks.Neuron to astrocyte communication via cannabinoid receptors is necessary for sustained epileptiform activity in rat hippocampus.Prevention or modification of epileptogenesis after brain insults: experimental approaches and translational research.Experimental and clinical evidence for loss of effect (tolerance) during prolonged treatment with antiepileptic drugs.The piriform cortex and human focal epilepsy.Studies on the effect of adenosine on calcium oscillation in hippocampal neuronsA prospective cohort study of prognosis for newly diagnosed epilepsy in east China.Epilepsy surgery: eligibility criteria and presurgical evaluation.Genetic polymorphism of drug refractory epilepsyCharacterization of the gene expression profile of human hippocampus in mesial temporal lobe epilepsy with hippocampal sclerosis.Relationship between ABCB1 3435TT genotype and antiepileptic drugs resistance in Epilepsy: updated systematic review and meta-analysisChallenges and opportunities in the application of pharmacogenetics to antiepileptic drug therapy.Epileptogenesis and rational therapeutic strategies.Refractory epilepsy: mechanisms and solutions.Characteristics of seizure frequency among Malaysian children diagnosed with structural-metabolic epilepsyNovel anticonvulsant drugs targeting voltage-dependent ion channels.Advances in PET imaging of P-glycoprotein function at the blood-brain barrier.Montelukast reduces seizures in pentylenetetrazol-kindled miceStandard antiepileptic drugs fail to block epileptiform activity in rat organotypic hippocampal slice cultures.NBQX, a highly selective competitive antagonist of AMPA and KA ionotropic glutamate receptors, increases seizures and mortality following picornavirus infectionMultidrug resistance in epilepsy: a pharmacogenomic update.Intrinsic severity as a determinant of antiepileptic drug refractoriness.Changes in the sensitivity of GABAA current rundown to drug treatments in a model of temporal lobe epilepsyAdverse antiepileptic drug effects: toward a clinically and neurobiologically relevant taxonomy.The drug-transporter gene MDR1 C3435T and G2677T/A polymorphisms and the risk of multidrug-resistant epilepsy in Turkish children.Commentary: novel delivery approaches for antiepileptic drugs: hope and hurdles.
P2860
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P2860
Drug resistance in epilepsy: putative neurobiologic and clinical mechanisms.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Drug resistance in epilepsy: putative neurobiologic and clinical mechanisms.
@ast
Drug resistance in epilepsy: putative neurobiologic and clinical mechanisms.
@en
type
label
Drug resistance in epilepsy: putative neurobiologic and clinical mechanisms.
@ast
Drug resistance in epilepsy: putative neurobiologic and clinical mechanisms.
@en
prefLabel
Drug resistance in epilepsy: putative neurobiologic and clinical mechanisms.
@ast
Drug resistance in epilepsy: putative neurobiologic and clinical mechanisms.
@en
P2860
P1433
P1476
Drug resistance in epilepsy: putative neurobiologic and clinical mechanisms.
@en
P2093
Dieter Schmidt
Wolfgang Löscher
P2860
P304
P356
10.1111/J.1528-1167.2005.54904.X
P577
2005-06-01T00:00:00Z