Phase 1 Safety, Pharmacokinetics, and Pharmacodynamics of Dapivirine and Maraviroc Vaginal Rings: A Double-Blind Randomized Trial
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Biomarkers and biometric measures of adherence to use of ARV-based vaginal ringsAnimal and human mucosal tissue models to study HIV biomedical interventions: can we predict success?Maraviroc: a review of its use in HIV infection and beyondA Novel Microbicide/Contraceptive Intravaginal Ring Protects Macaque Genital Mucosa against SHIV-RT Infection Ex VivoDrug transporters in tissues and cells relevant to sexual transmission of HIV: Implications for drug deliveryImportance of Drug Pharmacokinetics at the Site of ActionHistorical development of vaginal microbicides to prevent sexual transmission of HIV in women: from past failures to future hopes.Pharmacokinetics of antiretrovirals in genital secretions and anatomic sites of HIV transmission: implications for HIV prevention.Biophysical characterization of small molecule antiviral-loaded nanolipogels for HIV-1 chemoprophylaxis and topical mucosal application.Impact of Sex on the Pharmacokinetics and Pharmacodynamics of 1% Tenofovir GelDistinct Pharmacodynamic Activity of Rilpivirine in Ectocervical and Colonic Explant Tissue.Combination Pod-Intravaginal Ring Delivers Antiretroviral Agents for HIV Prophylaxis: Pharmacokinetic Evaluation in an Ovine ModelSimultaneous measurement of etravirine, maraviroc and raltegravir in pigtail macaque plasma, vaginal secretions and vaginal tissue using a LC-MS/MS assay.Pharmacodynamic correlations using fresh and cryopreserved tissue following use of vaginal rings containing dapivirine and/or maraviroc in a randomized, placebo controlled trial.Use of a Vaginal Ring Containing Dapivirine for HIV-1 Prevention in WomenCXCR4-using HIV variants in a cohort of Black men who have sex with men: HIV Prevention Trials Network 061.A Phase 1 Trial to Assess the Safety, Acceptability, Pharmacokinetics, and Pharmacodynamics of a Novel Dapivirine Vaginal Film.CD4-mimetic sulfopeptide conjugates display sub-nanomolar anti-HIV-1 activity and protect macaques against a SHIV162P3 vaginal challenge.Frequent Cross-Resistance to Dapivirine in HIV-1 Subtype C-Infected Individuals after First-Line Antiretroviral Therapy Failure in South AfricaM48U1 and Tenofovir combination synergistically inhibits HIV infection in activated PBMCs and human cervicovaginal histocultures.Pharmacokinetics of the protein microbicide 5P12-RANTES in sheep following single dose vaginal gel administration.The Vaginal Microbiome and its Potential to Impact Efficacy of HIV Pre-exposure Prophylaxis for Women.Attitudes and perceptions towards novel objective measures of ARV-based vaginal ring use: Results from a global stakeholder survey.The future of pre-exposure prophylaxis (PrEP) for human immunodeficiency virus (HIV) infection.Implementation of a Novel Adherence Monitoring Strategy in a Phase III, Blinded, Placebo-Controlled, HIV-1 Prevention Clinical Trial.Analytical Advances in the Ex Vivo Challenge Efficacy Assay.Adherence and Acceptability of a Multidrug Vaginal Ring for HIV Prevention in a Phase I Study in the United States.Potent Inhibition of HIV-1 Replication in Resting CD4 T Cells by Resveratrol and Pterostilbene.In Vitro Cross-Resistance Profiles of Rilpivirine, Dapivirine, and MIV-150, Nonnucleoside Reverse Transcriptase Inhibitor Microbicides in Clinical Development for the Prevention of HIV-1 Infection.Comparison of Dapivirine Vaginal Gel and Film Formulation Pharmacokinetics and Pharmacodynamics (FAME 02B).Rapidly Biodegrading PLGA-Polyurethane Fibers for Sustained Release of Physicochemically Diverse Drugs.In vitro-ex vivo correlations between a cell-laden hydrogel and mucosal tissue for screening composite delivery systems.A Dose Ranging Pharmacokinetic Evaluation of IQP-0528 Released from Intravaginal Rings in Non-Human Primates.Antiretroviral drug-loaded nanoparticles-in-films: a new option for developing vaginal microbicides?Physiologically-based pharmacokinetic model of vaginally administered dapivirine ring and film formulationsSafety and pharmacokinetics of single, dual, and triple antiretroviral drug formulations delivered by pod-intravaginal rings designed for HIV-1 prevention: A Phase I trial
P2860
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P2860
Phase 1 Safety, Pharmacokinetics, and Pharmacodynamics of Dapivirine and Maraviroc Vaginal Rings: A Double-Blind Randomized Trial
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Phase 1 Safety, Pharmacokineti ...... Double-Blind Randomized Trial
@ast
Phase 1 Safety, Pharmacokineti ...... Double-Blind Randomized Trial
@en
type
label
Phase 1 Safety, Pharmacokineti ...... Double-Blind Randomized Trial
@ast
Phase 1 Safety, Pharmacokineti ...... Double-Blind Randomized Trial
@en
prefLabel
Phase 1 Safety, Pharmacokineti ...... Double-Blind Randomized Trial
@ast
Phase 1 Safety, Pharmacokineti ...... Double-Blind Randomized Trial
@en
P2093
P2860
P1476
Phase 1 Safety, Pharmacokineti ...... Double-Blind Randomized Trial
@en
P2093
Annalene Nel
Ariane van der Straten
Beatrice A Chen
Charlene S Dezzutti
Craig J Hoesley
Craig W Hendrix
Lori Panther
Lorna K Rabe
Lydia Soto-Torres
Mark A Marzinke
P2860
P304
P356
10.1097/QAI.0000000000000702
P407
P577
2015-05-28T00:00:00Z