Mammalian ribonucleotide reductase subunit p53R2 is required for mitochondrial DNA replication and DNA repair in quiescent cells
about
Nucleotide salvage deficiencies, DNA damage and neurodegenerationRibonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA Replicationp53 and mitochondrial function in neurons.The contribution of mitochondrial thymidylate synthesis in preventing the nuclear genome stressNucleotide excision repair efficiency in quiescent human fibroblasts is modulated by circadian clockThe contribution of CMP kinase to the efficiency of DNA repairRibonucleotide reductase subunit M2 predicts survival in subgroups of patients with non-small cell lung carcinoma: effects of gender and smoking statusMPV17 Loss Causes Deoxynucleotide Insufficiency and Slow DNA Replication in MitochondriaIdentification of Genetic Factors that Modify Clinical Onset of Huntington's Disease.Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress.PYCR1 and PYCR2 Interact and Collaborate with RRM2B to Protect Cells from Overt Oxidative Stress.Ribonucleotide reductase association with mammalian liver mitochondria.Oxidized dNTPs and the OGG1 and MUTYH DNA glycosylases combine to induce CAG/CTG repeat instability.The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells.p21-mediated RNR2 repression restricts HIV-1 replication in macrophages by inhibiting dNTP biosynthesis pathway.Bcl2 induces DNA replication stress by inhibiting ribonucleotide reductaseFunctional characterization of drim2, the Drosophila melanogaster homolog of the yeast mitochondrial deoxynucleotide transporter.CREB1 directly activates the transcription of ribonucleotide reductase small subunit M2 and promotes the aggressiveness of human colorectal cancerRibonucleotide reductase and cancer: biological mechanisms and targeted therapies.Deoxyribonucleotide metabolism, mutagenesis and cancer.5-aza-2',2'-Difluroro Deoxycytidine (NUC013): A Novel Nucleoside DNA Methyl Transferase Inhibitor and Ribonucleotide Reductase Inhibitor for the Treatment of CancerClofarabine Has Apoptotic Effect on T47D Breast Cancer Cell Line via P53R2 Gene ExpressionCaspase-dependent Proteolysis of Human Ribonucleotide Reductase Small Subunits R2 and p53R2 during Apoptosis.Synthesis of mitochondrial DNA precursors during myogenesis, an analysis in purified C2C12 myotubes.Mitochondrial quality control: Cell-type-dependent responses to pathological mutant mitochondrial DNATargeting Nucleotide Biosynthesis: A Strategy for Improving the Oncolytic Potential of DNA Viruses.Allosteric regulation of the human and mouse deoxyribonucleotide triphosphohydrolase sterile α-motif/histidine-aspartate domain-containing protein 1 (SAMHD1).A ribonucleotide reductase inhibitor with deoxyribonucleoside-reversible cytotoxicity.Out of S-phase: shift of subunits for ribonucleotide reductionTransgene expression of Drosophila melanogaster nucleoside kinase reverses mitochondrial thymidine kinase 2 deficiency.Administration of deoxyribonucleosides or inhibition of their catabolism as a pharmacological approach for mitochondrial DNA depletion syndrome.E2F1 regulates p53R2 gene expression in p53-deficient cells.Transcriptomic pathway analysis of urokinase receptor silenced breast cancer cells: a microarray study.p53R2 as a novel prognostic biomarker in nasopharyngeal carcinoma.Nuclear genes involved in mitochondrial diseases caused by instability of mitochondrial DNA.Challenges to DNA replication in hypoxic conditions.RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin)RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)A transgenic zebrafish model expressing KIT-D816V recapitulates features of aggressive systemic mastocytosis.SAMHD1: Recurring roles in cell cycle, viral restriction, cancer, and innate immunity.
P2860
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P2860
Mammalian ribonucleotide reductase subunit p53R2 is required for mitochondrial DNA replication and DNA repair in quiescent cells
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Mammalian ribonucleotide reduc ...... DNA repair in quiescent cells
@ast
Mammalian ribonucleotide reduc ...... DNA repair in quiescent cells
@en
type
label
Mammalian ribonucleotide reduc ...... DNA repair in quiescent cells
@ast
Mammalian ribonucleotide reduc ...... DNA repair in quiescent cells
@en
prefLabel
Mammalian ribonucleotide reduc ...... DNA repair in quiescent cells
@ast
Mammalian ribonucleotide reduc ...... DNA repair in quiescent cells
@en
P2093
P2860
P356
P1476
Mammalian ribonucleotide reduc ...... DNA repair in quiescent cells
@en
P2093
Giovanna Pontarin
Leonardo Bee
Paola Ferraro
Peter Reichard
Vera Bianchi
P2860
P304
13302-13307
P356
10.1073/PNAS.1211289109
P407
P577
2012-07-30T00:00:00Z