High glucose is necessary for complete maturation of Pdx1-VP16-expressing hepatic cells into functional insulin-producing cells - Wikidata - awgldk - TriplyDB

High glucose is necessary for complete maturation of Pdx1-VP16-expressing hepatic cells into functional insulin-producing cells

High glucose is necessary for complete maturation of Pdx1-VP16-expressing hepatic cells into functional insulin-producing cells

http://www.wikidata.org/entity/Q36173431

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Pdx-1 or Pdx-1-VP16 protein transduction induces beta-cell gene expression in liver-stem WB cells Directed differentiation of human iPSC into insulin producing cells is improved by induced expression of PDX1 and NKX6.1 factors in IPC progenitors A feat of metabolic proportions: Pdx1 orchestrates islet development and function in the maintenance of glucose homeostasis.Bipotential mouse embryonic liver (BMEL) cells spontaneously express Pdx1 and Ngn3 but do not undergo further pancreatic differentiation upon Hes1 down-regulation.Xenopus pancreas development Dynamic glucoregulation and mammalian-like responses to metabolic and developmental disruption in zebrafish.Membranes to achieve immunoprotection of transplanted islets.Human liver cells expressing albumin and mesenchymal characteristics give rise to insulin-producing cells Combinatorial treatment of bone marrow stem cells and stromal cell-derived factor 1 improves glycemia and insulin production in diabetic mice.Long-term correction of diabetes in rats after lentiviral hepatic insulin gene therapy.In vitro generation of functional insulin-producing cells from human bone marrow-derived stem cells, but long-term culture running risk of malignant transformation.Identity deception: not a crime for a stem cell.Pancreatic duodenal homeobox 1 protein is a novel beta-cell-specific autoantigen for type I diabetes.Reprogramming liver-stem WB cells into functional insulin-producing cells by persistent expression of Pdx1- and Pdx1-VP16 mediated by lentiviral vectors.Reversal of streptozotocin-induced diabetes in mice by cellular transduction with recombinant pancreatic transcription factor pancreatic duodenal homeobox-1: a novel protein transduction domain-based therapy.New sources of pancreatic beta-cells.Stem cells in the treatment of diabetes.The potential for stem cell therapy in diabetes.Liver stem cell-derived beta-cell surrogates for treatment of type 1 diabetes.Genetically reprogrammed, liver-derived insulin-producing cells are glucose-responsive, but susceptible to autoimmune destruction in settings of murine model of type 1 diabetes.Diabetes associated cell stress and dysfunction: role of mitochondrial and non-mitochondrial ROS production and activity.Differential ability of Ptf1a and Ptf1a-VP16 to convert stomach, duodenum and liver to pancreas The reprogrammed pancreatic progenitor-like intermediate state of hepatic cells is more susceptible to pancreatic beta cell differentiation.Diabetes mellitus: an opportunity for therapy with stem cells?Stem cell-based therapy in gastroenterology and hepatology.Multifunctional magnetic nanocarriers for image-tagged SiRNA delivery to intact pancreatic islets Are stem cells a cure for diabetes?Regenerating the epigenome.Role of pancreatic transcription factors in maintenance of mature β-cell function.In vitro differentiation of human amniotic epithelial cells into insulin-producing 3D spheroids.Implantation of bFGF-treated islet progenitor cells ameliorates streptozotocin-induced diabetes in rats.Cathepsin B contributes to autophagy-related 7 (Atg7)-induced nod-like receptor 3 (NLRP3)-dependent proinflammatory response and aggravates lipotoxicity in rat insulinoma cell line.Pdx1 protein induces human embryonic stem cells into the pancreatic endocrine lineage.Pancreatic and duodenal homeobox gene 1 (Pdx1) down-regulates hepatic transcription factor 1 alpha (HNF1α) expression during reprogramming of human hepatic cells into insulin-producing cells.Pleiotropic Roles of PDX-1 in the Pancreas Stem cells, a two-edged sword: risks and potentials of regenerative medicine.Long-term reversal of diabetes in non-obese diabetic mice by liver-directed gene therapy.Improvement of isolated caprine islet survival and functionality in vitro by enhancing of PDX1 gene expression.The combined effect of Pdx1 overexpression and Shh manipulation on the function of insulin-producing cells derived from adipose-tissue stem cells.

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High glucose is necessary for complete maturation of Pdx1-VP16-expressing hepatic cells into functional insulin-producing cells

http://www.wikidata.org/entity/Q36173431

description

2004 nî lūn-bûn

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2004年の論文

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2004年論文

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2004年論文

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2004年论文

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High glucose is necessary for ...... tional insulin-producing cells

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High glucose is necessary for ...... tional insulin-producing cells

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P2093

Dong-Qi Tang

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Li-Jun Yang

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Li-Zhen Cao

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Marko E Horb

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Shi-Wu Li

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P2860

PDX:PBX complexes are required for normal proliferation of pancreatic cells during development

Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia

Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors

In vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells

In-vitro differentiation of pancreatic beta-cells.

Gene expression cascades in pancreatic development.

Reversal of hyperglycemia in mice by using human expandable insulin-producing cells differentiated from fetal liver progenitor cells.

Evaluation of the differentiation potential of WB-F344 rat liver epithelial stem-like cells in vivo. Differentiation to hepatocytes after transplantation into dipeptidylpeptidase-IV-deficient rat liver.

Regulation of insulin secretion: insights from engineered beta-cell lines.

In vivo and in vitro characterization of insulin-producing cells obtained from murine bone marrow.

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