Mechanism-based inactivation of cytochrome P450 2B6 by methadone through destruction of prosthetic heme

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Pharmacogenetics of cytochrome P450 2B6 (CYP2B6): advances on polymorphisms, mechanisms, and clinical relevance Human Cytochrome P450 3A4 as a Biocatalyst: Effects of the Engineered Linker in Modulation of Coupling Efficiency in 3A4-BMR Chimeras.

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P2860

Mechanism-based inactivation of cytochrome P450 2B6 by methadone through destruction of prosthetic heme

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2012 nî lūn-bûn

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2012年論文

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2012年論文

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2012年论文

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name

Mechanism-based inactivation o ...... destruction of prosthetic heme

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Mechanism-based inactivation o ...... destruction of prosthetic heme

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Mechanism-based inactivation o ...... destruction of prosthetic heme

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Mechanism-based inactivation o ...... destruction of prosthetic heme

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Mechanism-based inactivation o ...... destruction of prosthetic heme

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Mechanism-based inactivation o ...... destruction of prosthetic heme

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Mechanism-based inactivation o ...... destruction of prosthetic heme

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Haoming Zhang

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Hemali T Amunugama

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Paul F Hollenberg

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P2860

Methadone N-demethylation in human liver microsomes: lack of stereoselectivity and involvement of CYP3A4

Structural Analysis of Mammalian Cytochrome P450 2B4 Covalently Bound to the Mechanism-Based Inactivator tert -Butylphenylacetylene: Insight into Partial Enzymatic Activity

Substrate specificity, regulation, and polymorphism of human cytochrome P450 2B6

Degradation of cytochrome P-450 haem by carbon tetrachloride and 2-allyl-2-isopropylacetamide in rat liver in vivo and in vitro. Involvement of non-carbon monoxide-forming mechanisms

THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE

Methadone: a substrate and mechanism-based inhibitor of CYP19 (aromatase).

A quantitative high-throughput 96-well plate fluorescence assay for mechanism-based inactivators of cytochromes P450 exemplified using CYP2B6.

Human cytochrome p450 inhibition and metabolic-intermediate complex formation by goldenseal extract and its methylenedioxyphenyl components.

Stereoselective metabolism of methadone N-demethylation by cytochrome P4502B6 and 2C19.

Methadone pharmacokinetics are independent of cytochrome P4503A (CYP3A) activity and gastrointestinal drug transport: insights from methadone interactions with ritonavir/indinavir.

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scholarly article

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10.1124/DMD.112.045971

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2012-06-08T00:00:00Z

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22685215

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3422545

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Mechanism-based inactivation of cytochrome P450 2B6 by methadone through destruction of prosthetic heme

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P2860

P2860

Mechanism-based inactivation of cytochrome P450 2B6 by methadone through destruction of prosthetic heme

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type

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P1433

P1476

P2093

P2860

P304

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P356

P433

P478

P577

P698

P932

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P1476

P2093

P2860

P304

P31

P356

P433

P478

P577

P698

P932