Krüppel-like factor 8 emerges as an important regulator of cancer
about
Klf8 regulates left-right asymmetric patterning through modulation of Kupffer's vesicle morphogenesis and spaw expression.Krüppel -like factor 8 is a stress-responsive transcription factor that regulates expression of HuR.Generation of mice deficient in both KLF3/BKLF and KLF8 reveals a genetic interaction and a role for these factors in embryonic globin gene silencingFunctional genomics screening utilizing mutant mouse embryonic stem cells identifies novel radiation-response genes.Expression of pre-selected TMEMs with predicted ER localization as potential classifiers of ccRCC tumors.Identification of epidermal growth factor receptor and its inhibitory microRNA141 as novel targets of Krüppel-like factor 8 in breast cancerERK2 phosphorylates Krüppel-like factor 8 protein at serine 48 to maintain its stability.Krüppel-like factor 8 promotes tumorigenic mammary stem cell induction by targeting miR-146a.Krüppel-like factor 8 activates the transcription of C-X-C cytokine receptor type 4 to promote breast cancer cell invasion, transendothelial migration and metastasis.KLF8 and FAK cooperatively enrich the active MMP14 on the cell surface required for the metastatic progression of breast cancerTransformation of human ovarian surface epithelial cells by Krüppel-like factor 8.Identification of epithelial stromal interaction 1 as a novel effector downstream of Krüppel-like factor 8 in breast cancer invasion and metastasisExpression of Kruppel-like factor 8 and Ki67 in lung adenocarcinoma and prognosis.Krüppel-like factors in mammalian stem cells and development.Krüppel-like factor 8 induces epithelial-to-mesenchymal transition and promotes invasion of pancreatic cancer cells through transcriptional activation of four and a half LIM-only protein 2Tumour-suppression function of KLF12 through regulation of anoikis.
P2860
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P2860
Krüppel-like factor 8 emerges as an important regulator of cancer
description
2012 nî lūn-bûn
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2012年の論文
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name
Krüppel-like factor 8 emerges as an important regulator of cancer
@ast
Krüppel-like factor 8 emerges as an important regulator of cancer
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type
label
Krüppel-like factor 8 emerges as an important regulator of cancer
@ast
Krüppel-like factor 8 emerges as an important regulator of cancer
@en
prefLabel
Krüppel-like factor 8 emerges as an important regulator of cancer
@ast
Krüppel-like factor 8 emerges as an important regulator of cancer
@en
P2860
P1476
Krüppel-like factor 8 emerges as an important regulator of cancer
@en
P2093
Satadru K Lahiri
P2860
P304
P407
P577
2012-07-27T00:00:00Z