p38 MAP kinase inhibitors: many are made, but few are chosen.
about
Changes in the expression of human cell division autoantigen-1 influence Toxoplasma gondii growth and developmentStructure-Activity Relationships and X-ray Structures Describing the Selectivity of Aminopyrazole Inhibitors for c-Jun N-terminal Kinase 3 (JNK3) over p38Synthesis, Biological Evaluation, X-ray Structure, and Pharmacokinetics of Aminopyrimidine c-jun-N-terminal Kinase (JNK) InhibitorsMechanism and consequence of the autoactivation of p38α mitogen-activated protein kinase promoted by TAB1Complex regulation and function of the inflammatory smooth muscle cell phenotype in atherosclerosisBaicalin downregulates Porphyromonas gingivalis lipopolysaccharide-upregulated IL-6 and IL-8 expression in human oral keratinocytes by negative regulation of TLR signaling.The p38alpha mitogen-activated protein kinase as a central nervous system drug discovery target.Two additive mechanisms impair the differentiation of 'substrate-selective' p38 inhibitors from classical p38 inhibitors in vitro.Targeting protein kinases in central nervous system disordersThe MAP kinase-activated protein kinase 2 (MK2) contributes to the Shiga toxin-induced inflammatory responseChiral kinase inhibitors.Molecular interaction studies using microscale thermophoresis.Back to the future: oral targeted therapy for RA and other autoimmune diseases.Label-free microscale thermophoresis discriminates sites and affinity of protein-ligand bindingDesign and synthesis of highly potent and isoform selective JNK3 inhibitors: SAR studies on aminopyrazole derivatives.Structural basis and biological consequences for JNK2/3 isoform selective aminopyrazoles.In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer.Topical alpha-selective p38 MAP kinase inhibition reduces acute skin inflammation in guinea pigMAPK usage in periodontal disease progression.Cellular mechanism of mechanotranscription in colonic smooth muscle cells.Integrin alpha1beta1 regulates matrix metalloproteinases via P38 mitogen-activated protein kinase in mesangial cells: implications for Alport syndrome.Novel host response therapeutic approaches to treat periodontal diseases.A potent and selective p38 inhibitor protects against bone damage in murine collagen-induced arthritis: a comparison with neutralization of mouse TNFalpha.Phosphoinositide 3-kinase signalling in lung disease: leucocytes and beyond.Pivotal Role of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 in Inflammatory Pulmonary Diseases.Activation of the p38 pathway by a novel monoketone curcumin analog, EF24, suggests a potential combination strategyMK2 inhibitor reduces alkali burn-induced inflammation in rat cornea.Toll gates to periodontal host modulation and vaccine therapy"Go upstream, young man": lessons learned from the p38 saga.Developing small molecules to inhibit kinases unkind to the heart: p38 MAPK as a case in point.Mitogen-activated protein kinases and their role in radiation response.Synthesis and SAR of novel isoxazoles as potent c-jun N-terminal kinase (JNK) inhibitors.Inhibition of SAPK2/p38 enhances sensitivity to mTORC1 inhibition by blocking IRES-mediated translation initiation in glioblastoma.Prediction of intracellular exposure bridges the gap between target- and cell-based drug discovery.Inhibition of p38 mitogen-activated protein kinase signaling reduces fibrosis and lipid accumulation after rotator cuff repair.A computational study on thiourea analogs as potent MK-2 inhibitors.Differential effects of p38MAP kinase inhibitors on the expression of inflammation-associated genes in primary, interleukin-1beta-stimulated human chondrocytes.Inhibition of HSP27 phosphorylation by a cell-permeant MAPKAP Kinase 2 inhibitor.Cell-specific inhibition of p38alpha as a therapeutic strategy for inflammatory bowel disease.In Silico Screening and In Vitro Activity Measurement of Javamide Analogues as Potential p38 MAPK Inhibitors.
P2860
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P2860
p38 MAP kinase inhibitors: many are made, but few are chosen.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
p38 MAP kinase inhibitors: many are made, but few are chosen.
@ast
p38 MAP kinase inhibitors: many are made, but few are chosen.
@en
type
label
p38 MAP kinase inhibitors: many are made, but few are chosen.
@ast
p38 MAP kinase inhibitors: many are made, but few are chosen.
@en
prefLabel
p38 MAP kinase inhibitors: many are made, but few are chosen.
@ast
p38 MAP kinase inhibitors: many are made, but few are chosen.
@en
P2093
P1476
p38 MAP kinase inhibitors: many are made, but few are chosen
@en
P2093
Celia Dominguez
David A Powers
Nuria Tamayo
P304
P577
2005-07-01T00:00:00Z