Strain background influences neurotoxicity and behavioral abnormalities in mice expressing the tetracycline transactivator. - Wikidata - awgldk - TriplyDB

Strain background influences neurotoxicity and behavioral abnormalities in mice expressing the tetracycline transactivator.

Strain background influences neurotoxicity and behavioral abnormalities in mice expressing the tetracycline transactivator.

http://www.wikidata.org/entity/Q36202682

about

Tau overexpression impacts a neuroinflammation gene expression network perturbed in Alzheimer's disease Lent-On-Plus Lentiviral vectors for conditional expression in human stem cells Transcriptional signatures of brain aging and Alzheimer's disease: What are our rodent models telling us?Sustained, neuron-specific IKK/NF-κB activation generates a selective neuroinflammatory response promoting local neurodegeneration with aging.Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory.Oligomeric tau-targeted immunotherapy in Tg4510 mice.Characterization of a Novel Mouse Model of Alzheimer's Disease--Amyloid Pathology and Unique β-Amyloid Oligomer Profile.Impairments in experience-dependent scaling and stability of hippocampal place fields limit spatial learning in a mouse model of Alzheimer's disease.Transgene expression in the Nop-tTA driver line is not inherently restricted to the entorhinal cortex.The anti-inflammatory glycoprotein, CD200, restores neurogenesis and enhances amyloid phagocytosis in a mouse model of Alzheimer's disease.Expression of A152T human tau causes age-dependent neuronal dysfunction and loss in transgenic mice.Reversible pathologic and cognitive phenotypes in an inducible model of Alzheimer-amyloidosis.Effects of the C57BL/6 strain background on tauopathy progression in the rTg4510 mouse model.Divergent phenotypes in mutant TDP-43 transgenic mice highlight potential confounds in TDP-43 transgenic modeling.Tet-On Systems For Doxycycline-inducible Gene Expression.Tracking progressive pathological and functional decline in the rTg4510 mouse model of tauopathy.Aberrant Cortical Activity in Multiple GCaMP6-Expressing Transgenic Mouse Lines.Using the mouse to model human disease: increasing validity and reproducibility Neuronal overexpression of Ube3a isoform 2 causes behavioral impairments and neuroanatomical pathology relevant to 15q11.2-q13.3 duplication syndrome.Discrete pools of oligomeric amyloid-β track with spatial learning deficits in a mouse model of Alzheimer amyloidosis.Practical considerations for choosing a mouse model of Alzheimer's disease.Hyperactivity with Agitative-Like Behavior in a Mouse Tauopathy Model.White matter tauopathy: Transient functional loss and novel myelin remodeling.Presymptomatic change in microRNAs modulates Tau pathology.Differential Neurotoxicity Related to Tetracycline Transactivator and TDP-43 Expression in Conditional TDP-43 Mouse Model of Frontotemporal Lobar Degeneration

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P2860

Strain background influences neurotoxicity and behavioral abnormalities in mice expressing the tetracycline transactivator.

http://www.wikidata.org/entity/Q36202682

description

2012 nî lūn-bûn

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Strain background influences n ...... e tetracycline transactivator.

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JNEUROSCI.0893-12.2012

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Journal of Neuroscience

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Strain background influences n ...... e tetracycline transactivator.

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Bryan J Song

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Carolyn C Allen

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Christie M Buchovecky

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Frank J Probst

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Harry J Han

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Heather A Born

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Hui-Chen Lu

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Joanna L Jankowsky

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Michael J Yetman

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Miguel A Marin

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P2860

Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

VP16 targets an amino-terminal domain of HCF involved in cell cycle progression

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

Tau suppression in a neurodegenerative mouse model improves memory function

GAL4-VP16 is an unusually potent transcriptional activator

Control of memory formation through regulated expression of a CaMKII transgene

Tau filament formation in transgenic mice expressing P301L tau.

The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2.

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10574-10586

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scholarly article

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10.1523/JNEUROSCI.0893-12.2012

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31

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2012-08-01T00:00:00Z

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230600048

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22855807

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