Progression to adrenocortical tumorigenesis in mice and humans through insulin-like growth factor 2 and β-catenin
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Mouse Models Recapitulating Human Adrenocortical Tumors: What Is Lacking?microRNAs as Potential Biomarkers in Adrenocortical Cancer: Progress and ChallengesDiagnostic and prognostic features in adrenocortical carcinoma: a single institution case series and review of the literatureWhole-exome sequencing characterizes the landscape of somatic mutations and copy number alterations in adrenocortical carcinoma.Extracellular activation of Wnt signaling through epigenetic dysregulation of Wnt inhibitory factor-1 (Wif-1) is associated with pathogenesis of adrenocortical tumor.Recurrent activating mutation in PRKACA in cortisol-producing adrenal tumorsIGF2 promotes growth of adrenocortical carcinoma cells, but its overexpression does not modify phenotypic and molecular features of adrenocortical carcinoma.Wnt signaling inhibits adrenal steroidogenesis by cell-autonomous and non-cell-autonomous mechanisms.Multilayer-omics analysis of renal cell carcinoma, including the whole exome, methylome and transcriptome.The combination of insulin-like growth factor receptor 1 (IGF1R) antibody cixutumumab and mitotane as a first-line therapy for patients with recurrent/metastatic adrenocortical carcinoma: a multi-institutional NCI-sponsored trialSingle nucleotide polymorphism array profiling of adrenocortical tumors--evidence for an adenoma carcinoma sequence?Pediatric adrenocortical tumors: what they can tell us on adrenal development and comparison with adult adrenal tumors.Genomic landscape of paediatric adrenocortical tumours.Adrenocortical carcinoma: clinical outcomes and prognosis of 330 patients at a tertiary care centerLoss of β-catenin in adrenocortical cancer cells causes growth inhibition and reversal of epithelial-to-mesenchymal transitionDevelopment of adrenal cortex zonation.Combined transcriptome studies identify AFF3 as a mediator of the oncogenic effects of β-catenin in adrenocortical carcinoma.Genomic and immunohistochemical analysis in human adrenal cortical neoplasia reveal beta-catenin mutations as potential prognostic biomarkerHepatocyte Growth Factor/cMET Pathway Activation Enhances Cancer Hallmarks in Adrenocortical Carcinoma.Integrated genome-wide analysis of genomic changes and gene regulation in human adrenocortical tissue samples.Regulation of the adrenocortical stem cell niche: implications for diseaseLow DICER1 expression is associated with poor clinical outcome in adrenocortical carcinoma.Mouse models of adrenocortical tumors.Activating mutations in CTNNB1 in aldosterone producing adenomas.Inhibition of the Tcf/beta-catenin complex increases apoptosis and impairs adrenocortical tumor cell proliferation and adrenal steroidogenesis.Dicer deficiency reveals microRNAs predicted to control gene expression in the developing adrenal cortex.Epigenetic silencing of RASSF1A deregulates cytoskeleton and promotes malignant behavior of adrenocortical carcinoma.The prevalence of CTNNB1 mutations in primary aldosteronism and consequences for clinical outcomes.Molecular Mechanisms of Stem/Progenitor Cell Maintenance in the Adrenal Cortex.Genetics and epigenetics of adrenocortical tumors.Steroidogenesis-adrenal cell signal transduction.Adrenocortical growth and cancer.Adrenocortical tumors and insulin resistance: What is the first step?5th International ACC Symposium: An Outlook to Current and Future Research on the Biology of Adrenocortical Carcinoma: Diagnostic and Therapeutic Applications.Rottlerin as a novel chemotherapy agent for adrenocortical carcinoma.Genetics of adrenocortical tumours.P53/Rb inhibition induces metastatic adrenocortical carcinomas in a preclinical transgenic model.Cell signaling pathways in the adrenal cortex: Links to stem/progenitor biology and neoplasia.Withanolides are potent novel targeted therapeutic agents against adrenocortical carcinomas.A CDK2 activity signature predicts outcome in CDK2-low cancers.
P2860
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P2860
Progression to adrenocortical tumorigenesis in mice and humans through insulin-like growth factor 2 and β-catenin
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Progression to adrenocortical ...... growth factor 2 and β-catenin
@ast
Progression to adrenocortical ...... growth factor 2 and β-catenin
@en
type
label
Progression to adrenocortical ...... growth factor 2 and β-catenin
@ast
Progression to adrenocortical ...... growth factor 2 and β-catenin
@en
prefLabel
Progression to adrenocortical ...... growth factor 2 and β-catenin
@ast
Progression to adrenocortical ...... growth factor 2 and β-catenin
@en
P2093
P2860
P50
P1476
Progression to adrenocortical ...... growth factor 2 and β-catenin
@en
P2093
Alex C Kim
Dafydd G Thomas
Derek P Simon
Elisabeth Starnes
Ferdous M Barlaskar
Gary D Hammer
Ibere C Soares
Joanne H Heaton
Lorena O Lima
Madson Q Almeida
P2860
P304
P356
10.1016/J.AJPATH.2012.05.026
P407
P577
2012-07-15T00:00:00Z