Molecular Pathways: Activating T Cells after Cancer Cell Phagocytosis from Blockade of CD47 "Don't Eat Me" Signals. - Wikidata - awgldk - TriplyDB

Molecular Pathways: Activating T Cells after Cancer Cell Phagocytosis from Blockade of CD47 "Don't Eat Me" Signals.

Molecular Pathways: Activating T Cells after Cancer Cell Phagocytosis from Blockade of CD47 "Don't Eat Me" Signals.

http://www.wikidata.org/entity/Q36208486

about

Long-Term Cultures of Human Cornea Limbal Explants Form 3D Structures Ex Vivo - Implications for Tissue Engineering and Clinical Applications Anti-CD47 Antibody As a Targeted Therapeutic Agent for Human Lung Cancer and Cancer Stem Cells.CD47 promotes ovarian cancer progression by inhibiting macrophage phagocytosis Silencing of CD47 and SIRPα by Polypurine reverse Hoogsteen hairpins to promote MCF-7 breast cancer cells death by PMA-differentiated THP-1 cells Original insights on thrombospondin-1-related antireceptor strategies in cancer.Of Cytometry, Stem Cells and Fountain of Youth.Secreted Thrombospondin-1 Regulates Macrophage Interleukin-1β Production and Activation through CD47.Role of Signal Regulatory Protein α in Arsenic Trioxide-induced Promyelocytic Leukemia Cell Apoptosis.Durable antitumor responses to CD47 blockade require adaptive immune stimulation.The use of CD47-modified biomaterials to mitigate the immune response.Signal regulatory protein α associated with the progression of oral leukoplakia and oral squamous cell carcinoma regulates phenotype switch of macrophages.Intravesical rAd-IFNα/Syn3 for Patients With High-Grade, Bacillus Calmette-Guerin-Refractory or Relapsed Non-Muscle-Invasive Bladder Cancer: A Phase II Randomized Study.Combination cancer immunotherapies tailored to the tumour microenvironment.Novel targets for natural killer/T-cell lymphoma immunotherapy.Opportunities and challenges for TCR mimic antibodies in cancer therapy Tumour-associated macrophages as treatment targets in oncology.Progress in nonviral gene therapy for breast cancer and what comes next?Current progress in innovative engineered antibodies.Tumor-associated macrophages, potential targets for cancer treatment.CD47 overexpression is associated with decreased neutrophil apoptosis/phagocytosis and poor prognosis in non-small-cell lung cancer patients.Blocking the CD47-SIRPα axis by delivery of anti-CD47 antibody induces antitumor effects in glioma and glioma stem cells.Blockage of the NLRP3 inflammasome by MCC950 improves anti-tumor immune responses in head and neck squamous cell carcinoma.Nanocage-Therapeutics Prevailing Phagocytosis and Immunogenic Cell Death Awakens Immunity against Cancer.Matricellular TSP-1 as a target of interest for impeding melanoma spreading: towards a therapeutic use for TAX2 peptide.The MYC oncogene is a global regulator of the immune response.Molecular functions of SIRPα and its role in cancer.Immunogenic effects of chemotherapy-induced tumor cell death

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Molecular Pathways: Activating T Cells after Cancer Cell Phagocytosis from Blockade of CD47 "Don't Eat Me" Signals.

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2015 nî lūn-bûn

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1078-0432.CCR-14-2520

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Clinical Cancer Research

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Molecular Pathways: Activating ...... f CD47 "Don't Eat Me" Signals.

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Adriel C Cha

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Irving L Weissman

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Melissa N McCracken

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P2860

Hallmarks of Cancer: The Next Generation

Calreticulin is the dominant pro-phagocytic signal on multiple human cancers and is counterbalanced by CD47

Anti-CD47 antibody-mediated phagocytosis of cancer by macrophages primes an effective antitumor T-cell response

The CD47-SIRPα pathway in cancer immune evasion and potential therapeutic implications

Engineered SIRPα variants as immunotherapeutic adjuvants to anticancer antibodies.

Antibody therapy targeting the CD47 protein is effective in a model of aggressive metastatic leiomyosarcoma

The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors

Extranodal dissemination of non-Hodgkin lymphoma requires CD47 and is inhibited by anti-CD47 antibody therapy

CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis

Role of CD47 as a marker of self on red blood cells

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3597-3601

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10.1158/1078-0432.CCR-14-2520

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2015-06-26T00:00:00Z

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