Genetic analysis of microtubule structure: a beta-tubulin mutation causes the formation of aberrant microtubules in vivo and in vitro
about
Two types of genetic interaction implicate the whirligig gene of Drosophila melanogaster in microtubule organization in the flagellar axoneme.Structural analysis of mutations in the Drosophila beta 2-tubulin isoform reveals regions in the beta-tubulin molecular required for general and for tissue-specific microtubule functions.Specific alpha- and beta-tubulin isotypes optimize the functions of sensory Cilia in Caenorhabditis elegansDeficiency screen identifies a novel role for beta 2 tubulin in salivary gland and myoblast migration in the Drosophila embryoIn vivo coassembly of a divergent beta-tubulin subunit (c beta 6) into microtubules of different functionGeneration of antisera that discriminate among mammalian alpha-tubulins: introduction of specialized isotypes into cultured cells results in their coassembly without disruption of normal microtubule function.Complex regulation and functional versatility of mammalian alpha- and beta-tubulin isotypes during the differentiation of testis and muscle cells.Mutations that encode partially functional beta 2 tubulin subunits have different effects on structurally different microtubule arrays.Differential utilization of beta-tubulin isotypes in differentiating neurites.The Drosophila kinesin-like protein KLP3A is a midbody component required for central spindle assembly and initiation of cytokinesisBipolar spindle attachments affect redistributions of ZW10, a Drosophila centromere/kinetochore component required for accurate chromosome segregation.Either alpha-tubulin isogene product is sufficient for microtubule function during all stages of growth and differentiation in Aspergillus nidulans.A codon change in beta-tubulin which drastically affects microtubule structure in Drosophila melanogaster fails to produce a significant phenotype in Saccharomyces cerevisiae.Interacting proteins identified by genetic interactions: a missense mutation in alpha-tubulin fails to complement alleles of the testis-specific beta-tubulin gene of Drosophila melanogaster.Diversity among beta-tubulins: a carboxy-terminal domain of yeast beta-tubulin is not essential in vivo.Three Drosophila beta-tubulin sequences: a developmentally regulated isoform (beta 3), the testis-specific isoform (beta 2), and an assembly-defective mutation of the testis-specific isoform (B2t8) reveal both an ancient divergence in metazoan isotyAn alpha-tubulin mutant destabilizes the heterodimer: phenotypic consequences and interactions with tubulin-binding proteinsStructurally similar Drosophila alpha-tubulins are functionally distinct in vivo.Further sequence requirements for male germ cell-specific expression under the control of the 14 bp promoter element (beta 2UE1) of the Drosophila beta 2 tubulin gene.Genetic evidence for interaction between eta- and beta-tubulins.A 14 bp promoter element directs the testis specificity of the Drosophila beta 2 tubulin gene.Functional constraint underlies 60 million year stasis of Dipteran testis-specific beta-tubulin.Cooperativity between the beta-tubulin carboxy tail and the body of the molecule is required for microtubule functionTwo Drosophila beta tubulin isoforms are not functionally equivalentThe Caenorhabditis elegans spe-6 gene is required for major sperm protein assembly and shows second site non-complementation with an unlinked deficiency.The best of all worlds or the best possible world? Developmental constraint in the evolution of beta-tubulin and the sperm tail axoneme.
P2860
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P2860
Genetic analysis of microtubule structure: a beta-tubulin mutation causes the formation of aberrant microtubules in vivo and in vitro
description
1987 nî lūn-bûn
@nan
1987年の論文
@ja
1987年論文
@yue
1987年論文
@zh-hant
1987年論文
@zh-hk
1987年論文
@zh-mo
1987年論文
@zh-tw
1987年论文
@wuu
1987年论文
@zh
1987年论文
@zh-cn
name
Genetic analysis of microtubul ...... rotubules in vivo and in vitro
@ast
Genetic analysis of microtubul ...... rotubules in vivo and in vitro
@en
type
label
Genetic analysis of microtubul ...... rotubules in vivo and in vitro
@ast
Genetic analysis of microtubul ...... rotubules in vivo and in vitro
@en
prefLabel
Genetic analysis of microtubul ...... rotubules in vivo and in vitro
@ast
Genetic analysis of microtubul ...... rotubules in vivo and in vitro
@en
P2093
P2860
P356
P1476
Genetic analysis of microtubul ...... rotubules in vivo and in vitro
@en
P2093
J A Hutchens
J H Caulton
M T Fuller
T C Kaufman
P2860
P304
P356
10.1083/JCB.104.3.385
P407
P577
1987-03-01T00:00:00Z