Stable analogues of OSB-AMP: potent inhibitors of MenE, the o-succinylbenzoate-CoA synthetase from bacterial menaquinone biosynthesis
about
Structural basis of the induced-fit mechanism of 1,4-dihydroxy-2-naphthoyl coenzyme A synthase from the crotonase fold superfamilyStructure of PA1221, a Nonribosomal Peptide Synthetase Containing Adenylation and Peptidyl Carrier Protein DomainsA Methyl 4-Oxo-4-phenylbut-2-enoate with in Vivo Activity against MRSA that Inhibits MenB in the Bacterial Menaquinone Biosynthesis PathwayPartial Saturation of Menaquinone in Mycobacterium tuberculosis: Function and Essentiality of a Novel Reductase, MenJIdentification of a hotdog fold thioesterase involved in the biosynthesis of menaquinone in Escherichia coli.The mycobacterial cell envelope-lipidsGeneral platform for systematic quantitative evaluation of small-molecule permeability in bacteria.Genetics of Capsular Polysaccharides and Cell Envelope (Glyco)lipids.Improved Synthesis of Biotinol-5'-AMP: Implications for Antibacterial Discovery.The tuberculosis drug discovery and development pipeline and emerging drug targets.Designed Small-Molecule Inhibitors of the Anthranilyl-CoA Synthetase PqsA Block Quinolone Biosynthesis in Pseudomonas aeruginosaNew Structural Templates for Clinically Validated and Novel Targets in Antimicrobial Drug Research and Development.Mechanism of MenE inhibition by acyl-adenylate analogues and discovery of novel antibacterial agentsCo-evolution of HAD phosphatase and hotdog-fold thioesterase domain function in the menaquinone-pathway fusion proteins BF1314 and PG1653.Tuberculosis drug discovery and emerging targets.Oxidative Phosphorylation as a Target Space for Tuberculosis: Success, Caution, and Future Directions.Discovery of bicyclic inhibitors against menaquinone biosynthesis.Novel long-chain compounds with both immunomodulatory and MenA inhibitory activities against Staphylococcus aureus and its biofilm.Structural Basis for the ATP-dependent Configuration of Adenylation Active Site in Bacillus subtilis o-Succinylbenzoyl-CoA Synthetase.Design, synthesis, and biological evaluation of α-hydroxyacyl-AMS inhibitors of amino acid adenylation enzymes.Crystal structure of the thioesterification conformation of Bacillus subtilis o-succinylbenzoyl-CoA synthetase reveals a distinct substrate-binding mode.Bioenergetics of Mycobacterium: An Emerging Landscape for Drug Discovery.Stereoselective Synthesis, Docking, and Biological Evaluation of Difluoroindanediol-Based MenE Inhibitors as Antibiotics.
P2860
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P2860
Stable analogues of OSB-AMP: potent inhibitors of MenE, the o-succinylbenzoate-CoA synthetase from bacterial menaquinone biosynthesis
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Stable analogues of OSB-AMP: p ...... erial menaquinone biosynthesis
@ast
Stable analogues of OSB-AMP: p ...... erial menaquinone biosynthesis
@en
type
label
Stable analogues of OSB-AMP: p ...... erial menaquinone biosynthesis
@ast
Stable analogues of OSB-AMP: p ...... erial menaquinone biosynthesis
@en
prefLabel
Stable analogues of OSB-AMP: p ...... erial menaquinone biosynthesis
@ast
Stable analogues of OSB-AMP: p ...... erial menaquinone biosynthesis
@en
P2093
P2860
P356
P1433
P1476
Stable analogues of OSB-AMP: p ...... erial menaquinone biosynthesis
@en
P2093
Derek S Tan
Gyanendra Kumar
Indrajeet Sharma
Peter J Tonge
Subramanyam Swaminathan
Xiaokai Li
Xuequan Lu
P2860
P304
P356
10.1002/CBIC.201100585
P577
2011-11-23T00:00:00Z