Cyclin E/Cdk2-dependent phosphorylation of Mcl-1 determines its stability and cellular sensitivity to BH3 mimetics
about
The potential of venetoclax (ABT-199) in chronic lymphocytic leukemiaProteomic Landscape of Tissue-Specific Cyclin E Functions in Vivo.Non-canonical functions of cell cycle cyclins and cyclin-dependent kinases.Critical reanalysis of the methods that discriminate the activity of CDK2 from CDK1miR-124 downregulation leads to breast cancer progression via LncRNA-MALAT1 regulation and CDK4/E2F1 signal activation.STAT3 and NF-κB cooperatively control in vitro spontaneous apoptosis and poor chemo-responsiveness in patients with chronic lymphocytic leukemia.FBW7 mutations mediate resistance of colorectal cancer to targeted therapies by blocking Mcl-1 degradation.Mitotic arrest-induced phosphorylation of Mcl-1 revisited using two-dimensional gel electrophoresis and phosphoproteomics: nine phosphorylation sites identified.Development of venetoclax for therapy of lymphoid malignancies.Targeting BET proteins improves the therapeutic efficacy of BCL-2 inhibition in T-cell acute lymphoblastic leukemia.Application of Mass Spectrometry Profiling to Establish Brusatol as an Inhibitor of Global Protein Synthesis.The BH3 mimetic drug ABT-737 induces apoptosis and acts synergistically with chemotherapeutic drugs in thyroid carcinoma cells.Phase 1 safety, pharmacokinetic and pharmacodynamic study of the cyclin-dependent kinase inhibitor dinaciclib administered every three weeks in patients with advanced malignancies.DNA damaging agent-induced apoptosis is regulated by MCL-1 phosphorylation and degradation mediated by the Noxa/MCL-1/CDK2 complex.Combined venetoclax and alvocidib in acute myeloid leukemia.Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor.Drug-resistance in doxorubicin-resistant FL5.12 hematopoietic cells: elevated MDR1, drug efflux and side-population positive and decreased BCL2-family member expression.Pathways and mechanisms of venetoclax resistance.
P2860
Q28075504-CCA57FD0-F3EB-4CBF-93EE-71F9CB824317Q36187252-361F6C1B-EB7A-44E9-8376-6196A47A30BDQ36827351-462E50F5-34D3-4BA6-ACC8-C3814A316534Q36956909-52D8596F-4B4F-4D43-ACA7-7F482B9F977DQ37085995-0FF8C150-21B6-4F6D-8E5B-179B53FAC127Q37362593-4732AC2B-6EFE-4E28-B9DC-94F473E6F5A2Q37580764-016FA3E2-12C9-4D26-9A62-045CBD5382DAQ37694737-0ACB82E9-E2E7-4CB3-AEAB-D3EC187FCCC7Q37702281-E3B5FEE7-6436-4BE4-9D05-DDD4B959F47CQ38722012-0B8A8CB7-FFBB-467A-910C-C98BBC4969ADQ38808418-896244BF-E899-4854-AA53-E3E5C878F17AQ39819844-F3CE4A7A-4BDB-41C6-AA1F-4F5D3EAA9342Q40041197-367E7AE9-A845-4D0A-9922-02E79B3F7BB0Q41667411-462004A1-70EA-4DDA-9E08-4F1FEA2B8EBEQ47105216-3FF42977-1A74-4733-B28D-AA3A5CB5A9EBQ47611731-85B22778-8296-41AD-BBEC-148F9EFB450AQ49882954-31EA67AE-68CB-453A-9578-25BAD9EBD944Q51160342-870C731A-E4EA-4C4D-940B-81A23D2D8437
P2860
Cyclin E/Cdk2-dependent phosphorylation of Mcl-1 determines its stability and cellular sensitivity to BH3 mimetics
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Cyclin E/Cdk2-dependent phosph ...... ar sensitivity to BH3 mimetics
@ast
Cyclin E/Cdk2-dependent phosph ...... ar sensitivity to BH3 mimetics
@en
type
label
Cyclin E/Cdk2-dependent phosph ...... ar sensitivity to BH3 mimetics
@ast
Cyclin E/Cdk2-dependent phosph ...... ar sensitivity to BH3 mimetics
@en
prefLabel
Cyclin E/Cdk2-dependent phosph ...... ar sensitivity to BH3 mimetics
@ast
Cyclin E/Cdk2-dependent phosph ...... ar sensitivity to BH3 mimetics
@en
P2093
P2860
P356
P1433
P1476
Cyclin E/Cdk2-dependent phosph ...... ar sensitivity to BH3 mimetics
@en
P2093
Alexandru Almasan
Brian T Hill
Mitchell R Smith
Saurav Misra
Suparna Mazumder
Trinh T Tat
P2860
P304
16912-16925
P356
10.18632/ONCOTARGET.4857
P407
P577
2015-07-01T00:00:00Z