The 78,000 M(r) intermediate chain of Chlamydomonas outer arm dynein isa WD-repeat protein required for arm assembly
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Loss-of-function mutations in a human gene related to Chlamydomonas reinhardtii dynein IC78 result in primary ciliary dyskinesia.Homozygosity mapping of a gene locus for primary ciliary dyskinesia on chromosome 5p and identification of the heavy dynein chain DNAH5 as a candidate geneMislocalization of DNAH5 and DNAH9 in respiratory cells from patients with primary ciliary dyskinesiaMutations of DNAI1 in primary ciliary dyskinesia: evidence of founder effect in a common mutationMutations in axonemal dynein assembly factor DNAAF3 cause primary ciliary dyskinesia.Cytoplasmic dynein binds dynactin through a direct interaction between the intermediate chains and p150GluedCytoplasmic dynein (ddlc1) mutations cause morphogenetic defects and apoptotic cell death in Drosophila melanogasterGenetic analysis of the cytoplasmic dynein subunit families.Genetic factors contributing to human primary ciliary dyskinesia and male infertilityStructure and function of outer dynein arm intermediate and light chain complex.A dynein light intermediate chain, D1bLIC, is required for retrograde intraflagellar transport.Functional analysis of an individual IFT protein: IFT46 is required for transport of outer dynein arms into flagella.Saccharomyces cerevisiae genes required in the absence of the CIN8-encoded spindle motor act in functionally diverse mitotic pathways.Structural organization of the dynein-dynactin complex bound to microtubulesBrain cytoplasmic and flagellar outer arm dyneins share a highly conserved Mr 8,000 light chainThe Tctex1/Tctex2 class of dynein light chains. Dimerization, differential expression, and interaction with the LC8 protein familyChlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagellaThe mouse t-complex-encoded protein Tctex-1 is a light chain of brain cytoplasmic dyneinA dynein light chain is essential for the retrograde particle movement of intraflagellar transport (IFT)IC138 is a WD-repeat dynein intermediate chain required for light chain assembly and regulation of flagellar bendingTCTEX1D2 mutations underlie Jeune asphyxiating thoracic dystrophy with impaired retrograde intraflagellar transport.Identification of a novel region of the cytoplasmic Dynein intermediate chain important for dimerization in the absence of the light chains.Phosphorylation regulates targeting of cytoplasmic dynein to kinetochores during mitosis.Identification and developmental regulation of a neuron-specific subunit of cytoplasmic dynein.Differential expression and phosphorylation of the 74-kDa intermediate chains of cytoplasmic dynein in cultured neurons and glia.Three-dimensional structures of the flagellar dynein-microtubule complex by cryoelectron microscopy.IC138 defines a subdomain at the base of the I1 dynein that regulates microtubule sliding and flagellar motilityConditional deletion of dnaic1 in a murine model of primary ciliary dyskinesia causes chronic rhinosinusitisProtein-protein interactions between intermediate chains and the docking complex of Chlamydomonas flagellar outer arm dynein.Restoring ciliary function to differentiated primary ciliary dyskinesia cells with a lentiviral vector.Modulation of cytoplasmic dynein ATPase activity by the accessory subunits.Cytoplasmic dynein intermediate-chain isoforms with different targeting properties created by tissue-specific alternative splicingThe outer dynein arm-docking complex: composition and characterization of a subunit (oda1) necessary for outer arm assemblyODA16p, a Chlamydomonas flagellar protein needed for dynein assemblyDrosophila Dynein intermediate chain gene, Dic61B, is required for spermatogenesis.Germline mutations in an intermediate chain dynein cause primary ciliary dyskinesia.Differential light chain assembly influences outer arm dynein motor function.Oda5p, a novel axonemal protein required for assembly of the outer dynein arm and an associated adenylate kinase.Interspecies conservation of outer arm dynein intermediate chain sequences defines two intermediate chain subclasses.Insights into the structural organization of the I1 inner arm dynein from a domain analysis of the 1beta dynein heavy chain.
P2860
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P2860
The 78,000 M(r) intermediate chain of Chlamydomonas outer arm dynein isa WD-repeat protein required for arm assembly
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
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1995年學術文章
@zh-hant
name
The 78,000 M(r) intermediate c ...... tein required for arm assembly
@ast
The 78,000 M(r) intermediate c ...... tein required for arm assembly
@en
type
label
The 78,000 M(r) intermediate c ...... tein required for arm assembly
@ast
The 78,000 M(r) intermediate c ...... tein required for arm assembly
@en
prefLabel
The 78,000 M(r) intermediate c ...... tein required for arm assembly
@ast
The 78,000 M(r) intermediate c ...... tein required for arm assembly
@en
P2093
P2860
P356
P1476
The 78,000 M(r) intermediate c ...... tein required for arm assembly
@en
P2093
A Koutoulis
C G Wilkerson
G B Witman
G J Pazour
P2860
P304
P356
10.1083/JCB.129.1.169
P407
P577
1995-04-01T00:00:00Z