The glucose transporter (GLUT-4) and vesicle-associated membrane protein-2 (VAMP-2) are segregated from recycling endosomes in insulin-sensitive cells.
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Association of the insulin receptor with phospholipase C-gamma (PLCgamma) in 3T3-L1 adipocytes suggests a role for PLCgamma in metabolic signaling by insulinGapex-5, a Rab31 guanine nucleotide exchange factor that regulates Glut4 trafficking in adipocytes.Syntaxin 7 is localized to late endosome compartments, associates with Vamp 8, and Is required for late endosome-lysosome fusionInsulin increases cell surface GLUT4 levels by dose dependently discharging GLUT4 into a cell surface recycling pathwayRole of EHD1 and EHBP1 in perinuclear sorting and insulin-regulated GLUT4 recycling in 3T3-L1 adipocytesRegulated localization of Rab18 to lipid droplets: effects of lipolytic stimulation and inhibition of lipid droplet catabolismExpression of a prenylation-deficient Rab4 inhibits the GLUT4 translocation induced by active phosphatidylinositol 3-kinase and protein kinase BSyntaxin 4 heterozygous knockout mice develop muscle insulin resistanceA tubular endosomal fraction from rat liver: biochemical evidence of receptor sorting by defaultVp165 and GLUT4 share similar vesicle pools along their trafficking pathways in rat adipose cellsA Glut4-vesicle marker protein, insulin-responsive aminopeptidase, is localized in a novel vesicular compartment in PC12 cellsMembrane amine oxidase cloning and identification as a major protein in the adipocyte plasma membraneMurine CENPF interacts with syntaxin 4 in the regulation of vesicular transportInsulin-regulated aminopeptidase is a key regulator of GLUT4 trafficking by controlling the sorting of GLUT4 from endosomes to specialized insulin-regulated vesiclesGLUT4 is sorted to vesicles whose accumulation beneath and insertion into the plasma membrane are differentially regulated by insulin and selectively affected by insulin resistanceLipid raft microdomain compartmentalization of TC10 is required for insulin signaling and GLUT4 translocation.NADPH oxidase is internalized by clathrin-coated pits and localizes to a Rab27A/B GTPase-regulated secretory compartment in activated macrophagesGLUT4--at the cross roads between membrane trafficking and signal transduction.Suppression of VAMP2 Alters Morphology of the Tegument and Affects Glucose uptake, Development and Reproduction of Schistosoma japonicumLipid rafts are required for GLUT4 internalization in adipose cells.Insulin-regulated release from the endosomal recycling compartment is regulated by budding of specialized vesicles.Characterization of insulin-responsive GLUT4 storage vesicles isolated from 3T3-L1 adipocytes.VAMP3 null mice display normal constitutive, insulin- and exercise-regulated vesicle trafficking.ADP-ribosylation factor 6 delineates separate pathways used by endothelin 1 and insulin for stimulating glucose uptake in 3T3-L1 adipocytes.Role of plasma membrane transporters in muscle metabolism.Identification of three distinct functional sites of insulin-mediated GLUT4 trafficking in adipocytes using quantitative single molecule imaging.Vesicle-associated membrane protein 2 (VAMP2) but Not VAMP3 mediates cAMP-stimulated trafficking of the renal Na+-K+-2Cl- co-transporter NKCC2 in thick ascending limbsLighting up insulin action.GLUT4 traffic through an ESCRT-III-dependent sorting compartment in adipocytes.Kinetic evidence that Glut4 follows different endocytic pathways than the receptors for transferrin and alpha2-macroglobulin.VAMP2, but not VAMP3/cellubrevin, mediates insulin-dependent incorporation of GLUT4 into the plasma membrane of L6 myoblasts.Insulin recruits GLUT4 from specialized VAMP2-carrying vesicles as well as from the dynamic endosomal/trans-Golgi network in rat adipocytesThyroid hormone promotes insulin-induced glucose uptake by enhancing Akt phosphorylation and VAMP2 translocation in 3T3-L1 adipocytesGLUT4 recycles via a trans-Golgi network (TGN) subdomain enriched in Syntaxins 6 and 16 but not TGN38: involvement of an acidic targeting motif.Conventional kinesin KIF5B mediates insulin-stimulated GLUT4 movements on microtubulesCharacterization of VAMP isoforms in 3T3-L1 adipocytes: implications for GLUT4 trafficking.Vesicle-associated membrane protein-2 (VAMP2) mediates cAMP-stimulated renin release in mouse juxtaglomerular cells.Push/pull mechanisms of GLUT4 traffic in muscle cells.SNARE-mediated rapid lysosome fusion in membrane raft clustering and dysfunction of bovine coronary arterial endothelium.Identification of discrete classes of endosome-derived small vesicles as a major cellular pool for recycling membrane proteins.
P2860
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P2860
The glucose transporter (GLUT-4) and vesicle-associated membrane protein-2 (VAMP-2) are segregated from recycling endosomes in insulin-sensitive cells.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh
1996年學術文章
@zh-hant
name
The glucose transporter (GLUT- ...... es in insulin-sensitive cells.
@ast
The glucose transporter (GLUT- ...... es in insulin-sensitive cells.
@en
type
label
The glucose transporter (GLUT- ...... es in insulin-sensitive cells.
@ast
The glucose transporter (GLUT- ...... es in insulin-sensitive cells.
@en
prefLabel
The glucose transporter (GLUT- ...... es in insulin-sensitive cells.
@ast
The glucose transporter (GLUT- ...... es in insulin-sensitive cells.
@en
P2093
P2860
P356
P1476
The glucose transporter (GLUT- ...... es in insulin-sensitive cells.
@en
P2093
P2860
P304
P356
10.1083/JCB.134.3.625
P407
P50
P577
1996-08-01T00:00:00Z