A "knockdown" mutation created by cis-element gene targeting reveals the dependence of erythroid cell maturation on the level of transcription factor GATA-1.
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Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1The TR2 and TR4 orphan nuclear receptors repress Gata1 transcriptionAbnormalities of GATA-1 in megakaryocytes from patients with idiopathic myelofibrosisPten dose dictates cancer progression in the prostateThe contribution of mouse models to the understanding of constitutional thrombocytopeniaThe transgeneticist's toolbox: novel methods for the targeted modification of eukaryotic genomesTranscription factor GATA-1 and Down syndrome leukemogenesisQuantitative histological image analyses of reticulin fibers in a myelofibrotic mouseRescue of the embryonic lethal hematopoietic defect reveals a critical role for GATA-2 in urogenital developmentA Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid developmentInositol polyphosphate 4-phosphatase type I regulates cell growth downstream of transcription factor GATA-1Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systemsAn Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombinationHP1gamma function is required for male germ cell survival and spermatogenesis.Inducible Gata1 suppression expands megakaryocyte-erythroid progenitors from embryonic stem cells.Truncated, inactive N-acetylglucosaminyltransferase III (GlcNAc-TIII) induces neurological and other traits absent in mice that lack GlcNAc-TIII.Differential requirements for the activation domain and FOG-interaction surface of GATA-1 in megakaryocyte gene expression and developmentc-Myb and GATA-1 alternate dominant roles during megakaryocyte differentiation.Repercussion of Megakaryocyte-Specific Gata1 Loss on Megakaryopoiesis and the Hematopoietic Precursor Compartment.GATA factor mutations in hematologic disease.Abnormal P-selectin localization during megakaryocyte development determines thrombosis in the gata1low model of myelofibrosisPathological interactions between hematopoietic stem cells and their niche revealed by mouse models of primary myelofibrosis.A gene-targeting approach identifies a function for the first intron in expression of the alpha1(I) collagen gene.GATA1 function, a paradigm for transcription factors in hematopoiesisCre-mediated germline mosaicism: a method allowing rapid generation of several alleles of a target gene.Dynamic regulation of Gata1 expression during the maturation of conventional dendritic cells.Localization of distant urogenital system-, central nervous system-, and endocardium-specific transcriptional regulatory elements in the GATA-3 locus.Genetic analysis of hierarchical regulation for Gata1 and NF-E2 p45 gene expression in megakaryopoiesisSENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesis.Evidence for organ-specific stem cell microenvironmentsThe effects of GATA-1 and NF-E2 deficiency on bone biomechanical, biochemical, and mineral properties.Lineage-specific combinatorial action of enhancers regulates mouse erythroid Gata1 expressionA cell type-specific allele of the POU gene Oct-6 reveals Schwann cell autonomous function in nerve development and regenerationPU.1 inhibits the erythroid program by binding to GATA-1 on DNA and creating a repressive chromatin structure.Expression of Neurog1 instead of Atoh1 can partially rescue organ of Corti cell survival.Exome sequencing identifies GATA1 mutations resulting in Diamond-Blackfan anemia.Point mutation in kit receptor tyrosine kinase reveals essential roles for kit signaling in spermatogenesis and oogenesis without affecting other kit responsesA hypomorphic mutation in the mouse laminin alpha5 gene causes polycystic kidney disease.An important regulatory role for CD4+CD8 alpha alpha T cells in the intestinal epithelial layer in the prevention of inflammatory bowel diseaseSubtle variations in Pten dose determine cancer susceptibility
P2860
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P2860
A "knockdown" mutation created by cis-element gene targeting reveals the dependence of erythroid cell maturation on the level of transcription factor GATA-1.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
A "knockdown" mutation created ...... f transcription factor GATA-1.
@ast
A "knockdown" mutation created ...... f transcription factor GATA-1.
@en
type
label
A "knockdown" mutation created ...... f transcription factor GATA-1.
@ast
A "knockdown" mutation created ...... f transcription factor GATA-1.
@en
prefLabel
A "knockdown" mutation created ...... f transcription factor GATA-1.
@ast
A "knockdown" mutation created ...... f transcription factor GATA-1.
@en
P2093
P2860
P356
P1476
A "knockdown" mutation created ...... f transcription factor GATA-1.
@en
P2093
P2860
P304
P356
10.1073/PNAS.94.13.6781
P407
P577
1997-06-01T00:00:00Z