An update of the pathophysiology of human gonadotrophin subunit and receptor gene mutations and polymorphisms.
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Genetic Models for the Study of Luteinizing Hormone Receptor FunctionEndocrine control of spermatogenesis: Role of FSH and LH/ testosteroneInfertility in Female Mice with a Gain-of-Function Mutation in the Luteinizing Hormone Receptor Is Due to Irregular Estrous Cyclicity, Anovulation, Hormonal Alterations, and Polycystic Ovaries.Precocious puberty and Leydig cell hyperplasia in male mice with a gain of function mutation in the LH receptor gene.A co-culture system reveals the involvement of intercellular pathways as mediators of the lutropin receptor (LHR)-stimulated ERK1/2 phosphorylation in Leydig cells.Activation of the lutropin/choriogonadotropin receptor in MA-10 cells stimulates tyrosine kinase cascades that activate ras and the extracellular signal regulated kinases (ERK1/2)."Been hit twice": a novel bi-allelic heterozygous mutation in LHCGR.The luteinizing hormone receptor: insights into structure-function relationships and hormone-receptor-mediated changes in gene expression in ovarian cancer cells.The luteinizing hormone beta-subunit exon 3 (Gly102Ser) gene mutation and ovarian responses to controlled ovarian hyperstimulationMutation analysis of the LH receptor gene in Leydig cell adenoma and hyperplasia and functional and biochemical studies of activating mutations of the LH receptor gene.A constitutively active mutant of the human lutropin receptor (hLHR-L457R) escapes lysosomal targeting and degradation.Association of luteinizing hormone chorionic gonadotropin receptor gene polymorphism (rs2293275) with polycystic ovarian syndrome.Constitutively active luteinizing hormone receptors: consequences of in vivo expression.Structure, function and regulation of gonadotropin receptors - a perspective.Association of the genetic variants of luteinizing hormone, luteinizing hormone receptor and polycystic ovary syndrome.Lutropin/choriogonadotropin stimulate the proliferation of primary cultures of rat Leydig cells through a pathway that involves activation of the extracellularly regulated kinase 1/2 cascade.Misfolding Ectodomain Mutations of the Lutropin Receptor Increase Efficacy of Hormone StimulationAn intracellular loop (IL2) residue confers different basal constitutive activities to the human lutropin receptor and human thyrotropin receptor through structural communication between IL2 and helix 6, via helix 3.Mechanisms of disease: Mutations of G proteins and G-protein-coupled receptors in endocrine diseases.Asp330 and Tyr331 in the C-terminal cysteine-rich region of the luteinizing hormone receptor are key residues in hormone-induced receptor activation.Association between the luteinizing hormone/chorionic gonadotropin receptor (LHCGR) rs4073366 polymorphism and ovarian hyperstimulation syndrome during controlled ovarian hyperstimulation.A distribution of two SNPs in exon 10 of the FSHR gene among the women with a diminished ovarian reserve in UkraineActivation of the lutropin/choriogonadotropin receptor inhibits apoptosis of immature Leydig cells in primary culture.A new LH receptor splice mutation responsible for male hypogonadism with subnormal sperm production in the propositus, and infertility with regular cycles in an affected sister.Luteinizing hormone and follicle stimulating hormone synergy: A review of role in controlled ovarian hyper-stimulation.Effects of polymorphisms in gonadotropin and gonadotropin receptor genes on reproductive function.Minireview: Insights Into the Structural and Molecular Consequences of the TSH-β Mutation C105Vfs114X.Wt1 is involved in leydig cell steroid hormone biosynthesis by regulating paracrine factor expression in mice.Association between genes encoding components of the Leutinizing hormone/Luteinizing hormone-choriogonadotrophin receptor pathway and polycystic ovary syndrome in Egyptian women.The ERK1/2 pathway regulates testosterone synthesis by coordinately regulating the expression of steroidogenic genes in Leydig cells.The frequency of follicle stimulating hormone receptor gene polymorphisms in Iranian infertile men with azoospermia.Structure and activation of the TSH receptor transmembrane domain.Impact of a constitutively active luteinizing hormone receptor on testicular gene expression and postnatal Leydig cell development.Mother-to-son transmission of a luteinizing hormone receptor activating mutation in a prepubertal child with testotoxicosis.Differences between lutropin-mediated and choriogonadotropin-mediated receptor activation.Exposure to cadmium during gestation and lactation affects development and function of Leydig cells in male offspring.SMAD3 Regulates Follicle-stimulating Hormone Synthesis by Pituitary Gonadotrope Cells in Vivo.Testicular Stem Cells Express Follicle-Stimulating Hormone Receptors and Are Directly Modulated by FSH.Constitutive luteinizing hormone receptor signaling causes sexual dysfunction and Leydig cell adenomas in male mice.
P2860
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P2860
An update of the pathophysiology of human gonadotrophin subunit and receptor gene mutations and polymorphisms.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
An update of the pathophysiolo ...... e mutations and polymorphisms.
@ast
An update of the pathophysiolo ...... e mutations and polymorphisms.
@en
type
label
An update of the pathophysiolo ...... e mutations and polymorphisms.
@ast
An update of the pathophysiolo ...... e mutations and polymorphisms.
@en
prefLabel
An update of the pathophysiolo ...... e mutations and polymorphisms.
@ast
An update of the pathophysiolo ...... e mutations and polymorphisms.
@en
P356
P1433
P1476
An update of the pathophysiolo ...... e mutations and polymorphisms.
@en
P2093
Axel P N Themmen
P304
P356
10.1530/REP.1.00663
P577
2005-09-01T00:00:00Z