Calcium dysregulation in Alzheimer's disease: recent advances gained from genetically modified animals.
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Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutationsFamilial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1Mitochondria, calcium and cell death: a deadly triad in neurodegenerationAlzheimer's disease; taking the edge off with cannabinoids?Glaucoma: the retina and beyondImplementing Silicon Nanoribbon Field-Effect Transistors as Arrays for Multiple Ion DetectionCalcium-sensitive regulation of monoamine oxidase-A contributes to the production of peroxyradicals in hippocampal cultures: implications for Alzheimer disease-related pathology.Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation.Workflow and methods of high-content time-lapse analysis for quantifying intracellular calcium signals.Alterations of brain and cerebellar proteomes linked to Aβ and tau pathology in a female triple-transgenic murine model of Alzheimer's disease.Calcium ions promote formation of amyloid β-peptide (1-40) oligomers causally implicated in neuronal toxicity of Alzheimer's disease.Effects of transmitters and amyloid-beta peptide on calcium signals in rat cortical astrocytes: Fura-2AM measurements and stochastic model simulationsGain-of-function enhancement of IP3 receptor modal gating by familial Alzheimer's disease-linked presenilin mutants in human cells and mouse neurons.Disturbed Ca2+ homeostasis increases glutaminyl cyclase expression; connecting two early pathogenic events in Alzheimer's disease in vitro.Mitofusin-2 knockdown increases ER-mitochondria contact and decreases amyloid β-peptide productionHippocampal interneuron loss in an APP/PS1 double mutant mouse and in Alzheimer's disease.Calpain cleavage and inactivation of the sodium calcium exchanger-3 occur downstream of Aβ in Alzheimer's disease.Hippocampal hyperactivation in presymptomatic familial Alzheimer's diseaseThe Ca(2+) channel inhibitor 2-APB reverses β-amyloid-induced LTP deficit in hippocampus by blocking BAX and caspase-3 hyperactivationMitochondrial- and endoplasmic reticulum-associated oxidative stress in Alzheimer's disease: from pathogenesis to biomarkers.A reversible early oxidized redox state that precedes macromolecular ROS damage in aging nontransgenic and 3xTg-AD mouse neuronsExenatide promotes cognitive enhancement and positive brain metabolic changes in PS1-KI mice but has no effects in 3xTg-AD animals.The pathogenesis of Alzheimers disease is it a lifelong "calciumopathy"?Toward structural elucidation of the gamma-secretase complex.Familial Alzheimer's disease mutations in presenilins: effects on endoplasmic reticulum calcium homeostasis and correlation with clinical phenotypes.Presenilins are enriched in endoplasmic reticulum membranes associated with mitochondria.Genetically encoded fluorescent sensors for studying healthy and diseased nervous systems.Soluble oligomeric amyloid-β induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain.Control of intracellular calcium signaling as a neuroprotective strategyNeuronal calcium signaling, mitochondrial dysfunction, and Alzheimer's disease.Calcium and neurogenesis in Alzheimer's disease.Synapses, NMDA receptor activity and neuronal Aβ production in Alzheimer's disease.The role of neuronal calcium sensors in balancing synaptic plasticity and synaptic dysfunction.Endoplasmic reticulum and the unfolded protein response: dynamics and metabolic integrationNeuronal calcium signaling: function and dysfunction.CHOLESTEROL AND NEURONAL SUSCEPTIBILITY TO BETA-AMYLOID TOXICITY.Cannabinoids in late-onset Alzheimer's disease.Mitochondrial Regulatory Pathways in the Pathogenesis of Alzheimer's Disease.The Role of Presenilin in Protein Trafficking and Degradation-Implications for Metal Homeostasis.Thapsigargin affects presenilin-2 but not presenilin-1 regulation in SK-N-BE cells.
P2860
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P2860
Calcium dysregulation in Alzheimer's disease: recent advances gained from genetically modified animals.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Calcium dysregulation in Alzhe ...... genetically modified animals.
@ast
Calcium dysregulation in Alzhe ...... genetically modified animals.
@en
type
label
Calcium dysregulation in Alzhe ...... genetically modified animals.
@ast
Calcium dysregulation in Alzhe ...... genetically modified animals.
@en
prefLabel
Calcium dysregulation in Alzhe ...... genetically modified animals.
@ast
Calcium dysregulation in Alzhe ...... genetically modified animals.
@en
P2093
P1433
P1476
Calcium dysregulation in Alzhe ...... genetically modified animals.
@en
P2093
Frank M LaFerla
Ian F Smith
Kim N Green
P304
P356
10.1016/J.CECA.2005.06.021
P577
2005-09-01T00:00:00Z