Haploinsufficiency of cathepsin D leads to lysosomal dysfunction and promotes cell-to-cell transmission of α-synuclein aggregates
about
Cellular proteostasis: degradation of misfolded proteins by lysosomesTherapeutic potential of autophagy-enhancing agents in Parkinson's disease.DnaJ/Hsc70 chaperone complexes control the extracellular release of neurodegenerative-associated proteins.The Role of Cathepsin D in the Pathogenesis of Human Neurodegenerative Disorders.How strong is the evidence that Parkinson's disease is a prion disorder?Engineered nanomaterial-induced lysosomal membrane permeabilization and anti-cathepsin agents.Selective imaging of internalized proteopathic α-synuclein seeds in primary neurons reveals mechanistic insight into transmission of synucleinopathies.Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy.Cerebrospinal fluid β-glucocerebrosidase activity is reduced in parkinson's disease patients.Increased Cathepsin D Correlates with Clinical Parameters in Newly Diagnosed Type 2 Diabetes.Haplodeficiency of Cathepsin D does not affect cerebral amyloidosis and autophagy in APP/PS1 transgenic mice.Pharmacological Inhibition of Necroptosis Protects from Dopaminergic Neuronal Cell Death in Parkinson's Disease Models.DNAJC5 facilitates USP19-dependent unconventional secretion of misfolded cytosolic proteins.LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation
P2860
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P2860
Haploinsufficiency of cathepsin D leads to lysosomal dysfunction and promotes cell-to-cell transmission of α-synuclein aggregates
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Haploinsufficiency of cathepsi ...... sion of α-synuclein aggregates
@ast
Haploinsufficiency of cathepsi ...... sion of α-synuclein aggregates
@en
type
label
Haploinsufficiency of cathepsi ...... sion of α-synuclein aggregates
@ast
Haploinsufficiency of cathepsi ...... sion of α-synuclein aggregates
@en
prefLabel
Haploinsufficiency of cathepsi ...... sion of α-synuclein aggregates
@ast
Haploinsufficiency of cathepsi ...... sion of α-synuclein aggregates
@en
P2093
P2860
P356
P1476
Haploinsufficiency of cathepsi ...... sion of α-synuclein aggregates
@en
P2093
P2860
P2888
P356
10.1038/CDDIS.2015.283
P577
2015-10-08T00:00:00Z
P5875
P6179
1002176073