The LDL receptor clustering motif interacts with the clathrin terminal domain in a reverse turn conformation
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The modular adaptor protein ARH is required for low density lipoprotein (LDL) binding and internalization but not for LDL receptor clustering in coated pitsARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2Transforming growth factor-beta receptors interact with AP2 by direct binding to beta2 subunitSla1p serves as the targeting signal recognition factor for NPFX(1,2)D-mediated endocytosis.Adaptor complex-independent clathrin function in yeast.Endocytosis and Trafficking of Natriuretic Peptide Receptor-A: Potential Role of Short Sequence MotifsThe transmembrane domain and PXXP motifs of ApoE receptor 2 exclude it from carrying out clathrin-mediated endocytosisDisabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2A requirement for ankyrin binding to clathrin during coated pit buddingImmunoglobulin-like domain containing receptor 1 mediates fat-stimulated cholecystokinin secretionClathrin-mediated endocytosis in AP-2-depleted cellsHuman rhinovirus type 2 is internalized by clathrin-mediated endocytosisThe adaptor protein GULP promotes Jedi-1-mediated phagocytosis through a clathrin-dependent mechanismInhibition of the receptor-binding function of clathrin adaptor protein AP-2 by dominant-negative mutant mu2 subunit and its effects on endocytosis.Regulation of the ligand binding activity of the human very low density lipoprotein receptor by protein kinase C-dependent phosphorylation.Epsin binds to clathrin by associating directly with the clathrin-terminal domain. Evidence for cooperative binding through two discrete sites.Molecular bases for the recognition of tyrosine-based sorting signalsCharacterization of a novel cellular defect in patients with phenotypic homozygous familial hypercholesterolemia.The disabled 1 phosphotyrosine-binding domain binds to the internalization signals of transmembrane glycoproteins and to phospholipidsMultiple interactions of auxilin 1 with clathrin and the AP-2 adaptor complex.Use of homozygosity mapping to identify a region on chromosome 1 bearing a defective gene that causes autosomal recessive homozygous hypercholesterolemia in two unrelated familiesSmall peptide recognition sequence for intracellular sorting.The coxsackie B virus and adenovirus receptor resides in a distinct membrane microdomain.Vesicular protein transport.A di-leucine sequence and a cluster of acidic amino acids are required for dynamic retention in the endosomal recycling compartment of fibroblasts.Cluster of differentiation antigen 4 (CD4) endocytosis and adaptor complex binding require activation of the CD4 endocytosis signal by serine phosphorylationFunctional roles of short sequence motifs in the endocytosis of membrane receptors.A 14-amino acid sequence with a beta-turn structure is required for apical membrane sorting of the rat ileal bile acid transporter.Inhibition of endocytic pathways impacts cytomegalovirus maturation.The ap-2 clathrin adaptor mediates endocytosis of an inhibitory killer cell Ig-like receptor in human NK cells.Macrophage colony-stimulating factor differentially regulates low density lipoprotein and transferrin receptors.The adaptor protein beta-arrestin2 enhances endocytosis of the low density lipoprotein receptor.Internalization-competent influenza hemagglutinin mutants form complexes with clathrin-deficient multivalent AP-2 oligomers in live cells.Identification of a VLDL-induced, FDNPVY-independent internalization mechanism for the LDLR.Mu 2 binding directs the cystic fibrosis transmembrane conductance regulator to the clathrin-mediated endocytic pathway.Xenopus autosomal recessive hypercholesterolemia protein couples lipoprotein receptors with the AP-2 complex in oocytes and embryos and is required for vitellogenesis.
P2860
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P2860
The LDL receptor clustering motif interacts with the clathrin terminal domain in a reverse turn conformation
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
The LDL receptor clustering mo ...... in a reverse turn conformation
@ast
The LDL receptor clustering mo ...... in a reverse turn conformation
@en
type
label
The LDL receptor clustering mo ...... in a reverse turn conformation
@ast
The LDL receptor clustering mo ...... in a reverse turn conformation
@en
prefLabel
The LDL receptor clustering mo ...... in a reverse turn conformation
@ast
The LDL receptor clustering mo ...... in a reverse turn conformation
@en
P2093
P2860
P356
P1476
The LDL receptor clustering mo ...... in a reverse turn conformation
@en
P2093
L M Gierasch
R G Anderson
R G Kibbey
P2860
P356
10.1083/JCB.142.1.59
P407
P577
1998-07-01T00:00:00Z