Expression of a truncated, kinase-defective TGF-beta type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis.
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Mechanisms for asporin function and regulation in articular cartilageSmad3 prevents beta-catenin degradation and facilitates beta-catenin nuclear translocation in chondrocytesA functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc diseaseTGF-β2 suppresses macrophage cytokine production and mucosal inflammatory responses in the developing intestineSusceptibility to collagen-induced arthritis is modulated by TGFbeta responsiveness of T cellsBMP receptor signaling is required for postnatal maintenance of articular cartilageTGF-β and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and diseaseAdvances in understanding cartilage remodelingOsteoarthritis pathogenesis: a review of molecular mechanismsInteraction of TGFβ and BMP signaling pathways during chondrogenesisAn aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritisLung alveolar septation defects in Ltbp-3-null miceSynovial joint formation requires local Ext1 expression and heparan sulfate production in developing mouse embryo limbs and spineDevelopmentally regulated expression of mouse HtrA3 and its role as an inhibitor of TGF-beta signalingMechanical regulation of terminal chondrocyte differentiation via RGD-CAP/beta ig-h3 induced by TGF-betaTAK1 is an essential regulator of BMP signalling in cartilageBone abnormalities in latent TGF-[beta] binding protein (Ltbp)-3-null mice indicate a role for Ltbp-3 in modulating TGF-[beta] bioavailabilitySnoN suppresses maturation of chondrocytes by mediating signal cross-talk between transforming growth factor-β and bone morphogenetic protein pathways.Inhibition of ALK5 signaling induces physeal dysplasia in rats.Identification of unique molecular subdomains in the perichondrium and periosteum and their role in regulating gene expression in the underlying chondrocytesDifferential gene expression associated with postnatal equine articular cartilage maturationGrowth factors in inflammatory bowel disease.Molecular profiling of the developing mouse axial skeleton: a role for Tgfbr2 in the development of the intervertebral disc.Biglycan and fibromodulin have essential roles in regulating chondrogenesis and extracellular matrix turnover in temporomandibular joint osteoarthritis.Inhibition of transforming growth factor-beta signaling induces left ventricular dilation and dysfunction in the pressure-overloaded heartSmad signaling in skeletal development and regeneration.Conditional removal of the canonical TGF-β1 signaling delays condylar cartilage degeneration induced by a partial discectomy in miceAdvanced glycation end-products induce tubular CTGF via TGF-beta-independent Smad3 signaling.Signaling pathways in cartilage repair.Targeting TGFβ signaling in subchondral bone and articular cartilage homeostasisToward regeneration of articular cartilage.A role for age-related changes in TGFbeta signaling in aberrant chondrocyte differentiation and osteoarthritisCathepsin B is the driving force of esophageal cell invasion in a fibroblast-dependent manner.Targeted disruption of Mig-6 in the mouse genome leads to early onset degenerative joint disease.Smad3 knock-out mice as a useful model to study intestinal fibrogenesisAberrant hypertrophy in Smad3-deficient murine chondrocytes is rescued by restoring transforming growth factor beta-activated kinase 1/activating transcription factor 2 signaling: a potential clinical implication for osteoarthritis.TGF-β type II receptor/MCP-5 axis: at the crossroad between joint and growth plate developmentTemporal exposure to chondrogenic factors modulates human mesenchymal stem cell chondrogenesis in hydrogels.Chondrogenic differentiation of mesenchymal stem cells: challenges and unfulfilled expectations.Regulation and Role of TGFβ Signaling Pathway in Aging and Osteoarthritis Joints
P2860
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P2860
Expression of a truncated, kinase-defective TGF-beta type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh
1997年學術文章
@zh-hant
name
Expression of a truncated, kin ...... rentiation and osteoarthritis.
@ast
Expression of a truncated, kin ...... rentiation and osteoarthritis.
@en
type
label
Expression of a truncated, kin ...... rentiation and osteoarthritis.
@ast
Expression of a truncated, kin ...... rentiation and osteoarthritis.
@en
prefLabel
Expression of a truncated, kin ...... rentiation and osteoarthritis.
@ast
Expression of a truncated, kin ...... rentiation and osteoarthritis.
@en
P2093
P2860
P356
P1476
Expression of a truncated, kin ...... rentiation and osteoarthritis.
@en
P2093
D M Sheehan
E H Filvaroff
P2860
P304
P356
10.1083/JCB.139.2.541
P407
P577
1997-10-01T00:00:00Z