Efficient replication of genotype 3a and 4a hepatitis C virus replicons in human hepatoma cells.
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Simultaneously Targeting the NS3 Protease and Helicase Activities for More Effective Hepatitis C Virus TherapyVirologic Tools for HCV Drug Resistance TestingHepatitis C Virus and Antiviral Drug ResistanceComparative molecular dynamics simulation of Hepatitis C Virus NS3/4A protease (Genotypes 1b, 3a and 4b) predicts conformational instability of the catalytic triad in drug resistant strainsCharacterization of the Anti-HCV Activities of the New Cyclophilin Inhibitor STG-175Exploration of acetanilide derivatives of 1-(ω-phenoxyalkyl)uracils as novel inhibitors of Hepatitis C Virus replicationThe combination of alisporivir plus an NS5A inhibitor provides additive to synergistic anti-hepatitis C virus activity without detectable cross-resistance.Host-cell sensors for Plasmodium activate innate immunity against liver-stage infectionA screen for novel hepatitis C virus RdRp inhibitor identifies a broad-spectrum antiviral compoundRegulation of the hepatitis C virus RNA replicase by endogenous lipid peroxidation.Hepatitis C virus genotype 5a subgenomic replicons for evaluation of direct-acting antiviral agents.Potency and resistance analysis of hepatitis C virus NS5B polymerase inhibitor BMS-791325 on all major genotypes.Cross-genotypic examination of hepatitis C virus polymerase inhibitors reveals a novel mechanism of action for thumb bindersNatural compounds isolated from Brazilian plants are potent inhibitors of hepatitis C virus replication in vitro.Identification, molecular cloning, and analysis of full-length hepatitis C virus transmitted/founder genotypes 1, 3, and 4New Methods in Tissue Engineering: Improved Models for Viral InfectionSEC14L2 enables pan-genotype HCV replication in cell culture.Analysis of the Enzymatic Activity of an NS3 Helicase Genotype 3a Variant Sequence Obtained from a Relapse Patient.Highly efficient full-length hepatitis C virus genotype 1 (strain TN) infectious culture system.Combination treatment with hepatitis C virus protease and NS5A inhibitors is effective against recombinant genotype 1a, 2a, and 3a viruses.Hepatitis C Virus Genotype 1 to 6 Protease Inhibitor Escape Variants: In Vitro Selection, Fitness, and Resistance Patterns in the Context of the Infectious Viral Life Cycle.The Spring α-Helix Coordinates Multiple Modes of HCV (Hepatitis C Virus) NS3 Helicase Action.Preclinical Profile and Clinical Efficacy of a Novel Hepatitis C Virus NS5A Inhibitor, EDP-239.Antiviral Nucleotide Incorporation by Recombinant Human Mitochondrial RNA Polymerase Is Predictive of Increased In Vivo Mitochondrial Toxicity Risk.Understanding the hepatitis C virus life cycle paves the way for highly effective therapies.Robust and persistent replication of the genotype 6a hepatitis C virus replicon in cell culture.The molecular and structural basis of advanced antiviral therapy for hepatitis C virus infection.Experimental models of hepatitis B and C - new insights and progressEnhancement of the Replication of Hepatitis C Virus Replicons of Genotypes 1 to 4 by Manipulation of CpG and UpA Dinucleotide Frequencies and Use of Cell Lines Expressing SECL14L2 for Antiviral Resistance Testing.Development and validation of a "capture-fusion" model to study drug sensitivity of patient-derived hepatitis C.Development of hepatitis C virus genotype 3a cell culture system.Antiviral activity of virocidal peptide derived from NS5A against two different HCV genotypes: an in vitro study.Antiviral Activity and Resistance Analysis of NS3/4A Protease Inhibitor Grazoprevir and NS5A Inhibitor Elbasvir in Hepatitis C Virus GT4 Replicons.Novel nucleoside analogues targeting HCV replication through an NS5A-dependent inhibition mechanism.Tuning a cellular lipid kinase activity adapts hepatitis C virus to replication in cell culture.Cell culture-adaptive mutations of NS5A affect replication of hepatitis C virus differentially depending on the viral genotypes.PTC725, an NS4B-Targeting Compound, Inhibits a Hepatitis C Virus Genotype 3 Replicon, as Predicted by Genome Sequence Analysis and Determined ExperimentallyNS5A Sequence Heterogeneity and Mechanisms of Daclatasvir Resistance in Hepatitis C Virus Genotype 4 InfectionThe Combination of Grazoprevir, a Hepatitis C Virus (HCV) NS3/4A Protease Inhibitor, and Elbasvir, an HCV NS5A Inhibitor, Demonstrates a High Genetic Barrier to Resistance in HCV Genotype 1a Replicons.Effects of short RNA structural analogues against hepatitis C virus genotypes 2, 3 and 4 in replicon cells.
P2860
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P2860
Efficient replication of genotype 3a and 4a hepatitis C virus replicons in human hepatoma cells.
description
2012 nî lūn-bûn
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2012年の論文
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2012年学术文章
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2012年学术文章
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2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
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2012年學術文章
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name
Efficient replication of genot ...... icons in human hepatoma cells.
@ast
Efficient replication of genot ...... icons in human hepatoma cells.
@en
type
label
Efficient replication of genot ...... icons in human hepatoma cells.
@ast
Efficient replication of genot ...... icons in human hepatoma cells.
@en
prefLabel
Efficient replication of genot ...... icons in human hepatoma cells.
@ast
Efficient replication of genot ...... icons in human hepatoma cells.
@en
P2093
P2860
P50
P356
P1476
Efficient replication of genot ...... icons in human hepatoma cells.
@en
P2093
Charles M Rice
Mohsan Saeed
Svetlana Marukian
Troels K H Scheel
P2860
P304
P356
10.1128/AAC.01256-12
P407
P577
2012-08-06T00:00:00Z