Targeted deletion of Klotho in kidney distal tubule disrupts mineral metabolism. - Wikidata - awgldk - TriplyDB

Targeted deletion of Klotho in kidney distal tubule disrupts mineral metabolism.

Targeted deletion of Klotho in kidney distal tubule disrupts mineral metabolism.

http://www.wikidata.org/entity/Q36280331

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Fibroblast growth factor 23 enhances renal klotho abundance FGF23 and vascular calcifications: another piece of the puzzle?Hypophosphatemic rickets: revealing novel control points for phosphate homeostasis.The kidney is the principal organ mediating klotho effects.α-Klotho protects against oxidative damage in pulmonary epithelia.The Chromatin Regulator BRPF3 Preferentially Activates the HBO1 Acetyltransferase but Is Dispensable for Mouse Development and Survival.Arterial klotho expression and FGF23 effects on vascular calcification and function.Parathyroid-specific deletion of Klotho unravels a novel calcineurin-dependent FGF23 signaling pathway that regulates PTH secretion.High dose intravenous iron, mineral homeostasis and intact FGF23 in normal and uremic rats Competitive interaction between fibroblast growth factor 23 and asymmetric dimethylarginine in patients with CKD.Soluble α -Klotho Serum Levels in Chronic Kidney Disease.Molecular basis of Klotho: from gene to function in aging Conditional Deletion of Fgfr1 in the Proximal and Distal Tubule Identifies Distinct Roles in Phosphate and Calcium Transport.α-Klotho Expression in Human Tissues.RNA sequencing for global gene expression associated with muscle growth in a single male modern broiler line compared to a foundational Barred Plymouth Rock chicken line Parathyroid hormone 1 receptor is essential to induce FGF23 production and maintain systemic mineral ion homeostasis.Fractional excretion of phosphorus modifies the association between fibroblast growth factor-23 and outcomes Serum FGF23 and risk of cardiovascular events in relation to mineral metabolism and cardiovascular pathology.Klotho deficiency disrupts hematopoietic stem cell development and erythropoiesis Regulation of renal phosphate handling: inter-organ communication in health and disease.Pathophysiology of Calcium, Phosphorus, and Magnesium Dysregulation in Chronic Kidney Disease.Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23.Klotho, the Holy Grail of the kidney: from salt sensitivity to chronic kidney disease.Xeno-Klotho Inhibits Parathyroid Hormone Signaling.Cardiac actions of fibroblast growth factor 23.Novel functions of circulating Klotho.Control of phosphate balance by the kidney and intestine.Pan-FGFR inhibition leads to blockade of FGF23 signaling, soft tissue mineralization, and cardiovascular dysfunction.Effects of klotho deletion from bone during chronic kidney disease.Parathyroid hormone controls paracellular Ca2+ transport in the thick ascending limb by regulating the tight-junction protein Claudin14.Chronic Hyperphosphatemia and Vascular Calcification Are Reduced by Stable Delivery of Soluble Klotho.A phosphate-centric paradigm for pathophysiology and therapy of chronic kidney disease Cardiovascular Effects of Renal Distal Tubule Deletion of the FGF Receptor 1 Gene.A Case of Hyperphosphatemia and Elevated Fibroblast Growth Factor 23: A Brief Review of Hyperphosphatemia and Fibroblast Growth Factor 23 Pathway.α-klotho and anemia in patients with chronic kidney disease patients: A new perspective.Cortical and trabecular bone are equally affected in rats with renal failure and secondary hyperparathyroidism.Fibroblast growth factor 23 is upregulated in the kidney in a chronic kidney disease rat model.Comparative proteome analysis of wild-type and klotho-knockout mouse kidneys using a combination of MALDI-IMS and LC-MS/MS.FGF23 affects the lineage fate determination of mesenchymal stem cells.

P2860

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P2860

Targeted deletion of Klotho in kidney distal tubule disrupts mineral metabolism.

http://www.wikidata.org/entity/Q36280331

description

2012 nî lūn-bûn

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2012年の論文

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

@zh-my

2012年学术文章

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2012年學術文章

@yue

2012年學術文章

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2012年學術文章

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name

Targeted deletion of Klotho in kidney distal tubule disrupts mineral metabolism.

@ast

Targeted deletion of Klotho in kidney distal tubule disrupts mineral metabolism.

@en

type

label

Targeted deletion of Klotho in kidney distal tubule disrupts mineral metabolism.

@ast

Targeted deletion of Klotho in kidney distal tubule disrupts mineral metabolism.

@en

prefLabel

Targeted deletion of Klotho in kidney distal tubule disrupts mineral metabolism.

@ast

Targeted deletion of Klotho in kidney distal tubule disrupts mineral metabolism.

@en

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P1433

Journal of the American Society of Nephrology

P1476

Targeted deletion of Klotho in kidney distal tubule disrupts mineral metabolism

@en

P2093

Göran Andersson

http://www.w3.org/2001/XMLSchema#string

Hannes Olauson

http://www.w3.org/2001/XMLSchema#string

Karolina Lindberg

http://www.w3.org/2001/XMLSchema#string

Risul Amin

http://www.w3.org/2001/XMLSchema#string

Tobias E Larsson

http://www.w3.org/2001/XMLSchema#string

P2860

FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

The autosomal dominant hypophosphatemic rickets R176Q mutation in fibroblast growth factor 23 resists proteolytic cleavage and enhances in vivo biological potency

Klotho converts canonical FGF receptor into a specific receptor for FGF23

Genetic evidence of serum phosphate-independent functions of FGF-23 on bone

The parathyroid is a target organ for FGF23 in rats

Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism

Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis

Circulating concentration of FGF-23 increases as renal function declines in patients with chronic kidney disease, but does not change in response to variation in phosphate intake in healthy volunteers.

Fibroblast growth factor 23 and risks of mortality and end-stage renal disease in patients with chronic kidney disease

P304

1641-1651

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scholarly article

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10.1681/ASN.2012010048

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10

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P478

23

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Annika Wernerson

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2012-08-09T00:00:00Z

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230645358

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22878961

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3458458

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