Somatic mutation in a cultured mouse myeloma cell affects antigen binding
about
Identification of mutant monoclonal antibodies with increased antigen bindingVariable region framework differences result in decreased or increased affinity of variant anti-digoxin antibodies.An immunoglobulin mutator that targets G.C base pairs.VH genes encoding the immune response to beta-(1,6)-galactan: somatic mutation in IgM molecules.A well-differentiated B-cell line is permissive for somatic mutation of a transfected immunoglobulin heavy-chain gene.Somatic diversification of S107 from an antiphosphocholine to an anti-DNA autoantibody is due to a single base change in its heavy chain variable region.Somatic diversification of immunoglobulins.Expression and rearrangement of homologous immunoglobulin VH genes in two mouse strains.Single amino acid substitution altering antigen-binding specificityPolymorphism in immunoglobulin heavy chains suggesting gene conversion.Galactan-binding antibodies. Diversity and structure of idiotypesEvidence for gene conversion among immunoglobulin heavy chain variable region genesMolecular characterization of the humoral responses to Cryptococcus neoformans infection and glucuronoxylomannan-tetanus toxoid conjugate immunization.Clusters of point mutations are found exclusively around rearranged antibody variable genesDNA rearrangement causes a high rate of spontaneous mutation at the immunoglobulin heavy-chain locus of a mouse myeloma cell line.Diversity at the variable-joining region boundary of lambda light chains has a pronounced effect on immunoglobulin ligand-binding activityHypermutation at the immunoglobulin heavy chain locus in a pre-B-cell line.Antigen-binding specificities of antibodies are primarily determined by seven residues of VH.Topographic analysis with monoclonal anti-idiotopes: probing the functional anatomy of immunoglobulin variable domains.The molecular origin of anti-DNA antibodies.Immunoglobulin V region variants in hybridoma cells. I. Isolation of a variant with altered idiotypic and antigen binding specificity.Idiotypic selection of an antibody mutant with changed hapten binding specificity, resulting from a point mutation in position 50 of the heavy chain.Chemical synthesis of idiotopes. Evidence that antisera to the same JH1 peptide detect multiple binding site-associated idiotopes.Revisiting the definition of somatic mutational status in B-cell tumors: does 98% homology mean that a V(H)-gene is unmutated?
P2860
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P2860
Somatic mutation in a cultured mouse myeloma cell affects antigen binding
description
1982 nî lūn-bûn
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1982年の論文
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1982年学术文章
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1982年学术文章
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1982年学术文章
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1982年学术文章
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1982年學術文章
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name
Somatic mutation in a cultured mouse myeloma cell affects antigen binding
@ast
Somatic mutation in a cultured mouse myeloma cell affects antigen binding
@en
type
label
Somatic mutation in a cultured mouse myeloma cell affects antigen binding
@ast
Somatic mutation in a cultured mouse myeloma cell affects antigen binding
@en
prefLabel
Somatic mutation in a cultured mouse myeloma cell affects antigen binding
@ast
Somatic mutation in a cultured mouse myeloma cell affects antigen binding
@en
P2093
P2860
P356
P1476
Somatic mutation in a cultured mouse myeloma cell affects antigen binding
@en
P2093
A M Giusti
M D Scharff
S Rudikoff
P2860
P304
P356
10.1073/PNAS.79.4.1240
P407
P577
1982-02-01T00:00:00Z