Cis-element mutated in GATA2-dependent immunodeficiency governs hematopoiesis and vascular integrity
about
Gata2b is a restricted early regulator of hemogenic endothelium in the zebrafish embryo.Hematopoietic Signaling Mechanism Revealed from a Stem/Progenitor Cell CistromeBCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesisGATA2 haploinsufficiency caused by mutations in a conserved intronic element leads to MonoMAC syndromeA Gata2-Dependent Transcription Network Regulates Uterine Progesterone Responsiveness and Endometrial Function.Gata2 cis-element is required for hematopoietic stem cell generation in the mammalian embryo.A MAD-Bayes Algorithm for State-Space Inference and Clustering with Application to Querying Large Collections of ChIP-Seq Data Sets.GATA factor mutations in hematologic disease.Intermediate phenotypes in patients with autosomal dominant hyper-IgE syndrome caused by somatic mosaicism.Molecular basis of crosstalk between oncogenic Ras and the master regulator of hematopoiesis GATA-2GATA2 deficiency-associated bone marrow disorder differs from idiopathic aplastic anemia.GATA2 deficiency.Genome-wide analyses identify KLF4 as an important negative regulator in T-cell acute lymphoblastic leukemia through directly inhibiting T-cell associated genes.Haematopoietic and immune defects associated with GATA2 mutation.Epigenetic Determinants of Erythropoiesis: Role of the Histone Methyltransferase SetD8 in Promoting Erythroid Cell Maturation and SurvivalHigh-Throughput siRNA Screening to Reveal GATA-2 Upstream Transcriptional Mechanisms in Hematopoietic Cells.Malat1 as an evolutionarily conserved lncRNA, plays a positive role in regulating proliferation and maintaining undifferentiated status of early-stage hematopoietic cells.GATA2 is required for lymphatic vessel valve development and maintenance.Cis-regulatory mechanisms governing stem and progenitor cell transitionsGata2 Is a Rheostat for Mesenchymal Stem Cell Fate in Male Mice.GATA Factor-G-Protein-Coupled Receptor Circuit Suppresses Hematopoiesis.Functional and molecular characterization of mouse Gata2-independent hematopoietic progenitorsMutations in GATA2 cause human NK cell deficiency with specific loss of the CD56(bright) subset.Establishment of a cell-type-specific genetic network by the mediator complex component Med1.Transcriptional mechanisms underlying hemoglobin synthesis.GATA2 and Lmo2 control angiogenesis and lymphangiogenesis via direct transcriptional regulation of neuropilin-2.Gata2 is required for HSC generation and survival.Acquired ASXL1 mutations are common in patients with inherited GATA2 mutations and correlate with myeloid transformation.GATA2 deficiency: a protean disorder of hematopoiesis, lymphatics, and immunity.The evolution of cellular deficiency in GATA2 mutationNew developments in clinical aspects of lymphatic disease.Mechanism governing a stem cell-generating cis-regulatory element.A regulatory network governing Gata1 and Gata2 gene transcription orchestrates erythroid lineage differentiation.Epigenetic and genetic mechanisms in red cell biology.Hematopoietic transcriptional mechanisms: from locus-specific to genome-wide vantage points.The GATA factor revolution in hematology.Enhancers and their dynamics during hematopoietic differentiation and emerging strategies for therapeutic action.Lymphatic vessel development: fluid flow and valve-forming cells.A remote GATA2 hematopoietic enhancer drives leukemogenesis in inv(3)(q21;q26) by activating EVI1 expression.Heterogeneity of GATA2-related myeloid neoplasms.
P2860
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P2860
Cis-element mutated in GATA2-dependent immunodeficiency governs hematopoiesis and vascular integrity
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Cis-element mutated in GATA2-d ...... poiesis and vascular integrity
@ast
Cis-element mutated in GATA2-d ...... poiesis and vascular integrity
@en
type
label
Cis-element mutated in GATA2-d ...... poiesis and vascular integrity
@ast
Cis-element mutated in GATA2-d ...... poiesis and vascular integrity
@en
prefLabel
Cis-element mutated in GATA2-d ...... poiesis and vascular integrity
@ast
Cis-element mutated in GATA2-d ...... poiesis and vascular integrity
@en
P2093
P2860
P356
P1476
Cis-element mutated in GATA2-d ...... poiesis and vascular integrity
@en
P2093
Emery H Bresnick
Jing Zhang
Jinyong Wang
Katherine R Calvo
Kirby D Johnson
Meghan E Boyer
Myung-Jeom Ryu
Steven M Holland
Sunduz Keles
P2860
P304
P356
10.1172/JCI61623
P407
P577
2012-09-10T00:00:00Z