Synthesis and biological evaluations of chalcones, flavones and chromenes as farnesoid x receptor (FXR) antagonists.

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Synthesis and biological evaluations of chalcones, flavones and chromenes as farnesoid x receptor (FXR) antagonists.

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2017 nî lūn-bûn

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2017年の論文

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年學術文章

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2017年學術文章

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2017年學術文章

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Synthesis and biological evalu ...... x receptor (FXR) antagonists.

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Synthesis and biological evalu ...... x receptor (FXR) antagonists.

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Item

label

Synthesis and biological evalu ...... x receptor (FXR) antagonists.

@ast

Synthesis and biological evalu ...... x receptor (FXR) antagonists.

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prefLabel

Synthesis and biological evalu ...... x receptor (FXR) antagonists.

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Synthesis and biological evalu ...... x receptor (FXR) antagonists.

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P1476

Synthesis and biological evalu ...... x receptor (FXR) antagonists.

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P2093

Chiwai Wong

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Deyang Sun

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Guoning Zhang

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Jinsong Liu

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Na Wang

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Qian Jiang

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Ruchi Verma

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Ruitang Deng

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Shuainan Liu

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Wenjuan Tan

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P2860

Identification of a nuclear receptor for bile acids

Bile-acid-activated receptors: targeting TGR5 and farnesoid-X-receptor in lipid and glucose disorders

Identification of a nuclear receptor that is activated by farnesol metabolites

FXR activation reverses insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa/fa) obese rats.

Discovery of sulfated sterols from marine invertebrates as a new class of marine natural antagonists of farnesoid-X-receptor.

Identification of trisubstituted-pyrazol carboxamide analogs as novel and potent antagonists of farnesoid X receptor.

Beyond bile acids: targeting Farnesoid X Receptor (FXR) with natural and synthetic ligands.

Binding mechanism of the farnesoid X receptor marine antagonist suvanine reveals a strategy to forestall drug modulation on nuclear receptors. Design, synthesis, and biological evaluation of novel ligands.

Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element.

FXR antagonism of NSAIDs contributes to drug-induced liver injury identified by systems pharmacology approach.

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303-309

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scholarly article

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10.1016/J.EJMECH.2017.02.037

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P478

129

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Wei-Shuo Fang

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2017-02-20T00:00:00Z

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P698

28235703

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5505628

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