Design and functional characterization of a novel, arrestin-biased designer G protein-coupled receptor.
about
Analyzing the roles of multi-functional proteins in cells: The case of arrestins and GRKsOptogenetic approaches for dissecting neuromodulation and GPCR signaling in neural circuitsSynthetic control of mammalian-cell motility by engineering chemotaxis to an orthogonal bioinert chemical signal.Gs-DREADD Knock-In Mice for Tissue-Specific, Temporal Stimulation of Cyclic AMP SignalingAllosteric modulation of M1 muscarinic acetylcholine receptor internalization and subcellular trafficking.Beyond the hammer and the scalpel: selective circuit control for the epilepsiesA New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior.Differential Regulation of ERK1/2 and mTORC1 Through T1R1/T1R3 in MIN6 CellsCK2 acts as a potent negative regulator of receptor-mediated insulin release in vitro and in vivo.DREADDs for Neuroscientists.DREADDS: Use and application in behavioral neuroscienceA G Protein-biased Designer G Protein-coupled Receptor Useful for Studying the Physiological Relevance of Gq/11-dependent Signaling Pathways.Allosteric modulation and functional selectivity of G protein-coupled receptors.Minireview: Novel aspects of M3 muscarinic receptor signaling in pancreatic β-cells.Deciphering and modulating G protein signalling in C. elegans using the DREADD technology.Novel designer receptors to probe GPCR signaling and physiologyA novel experimental strategy to assess the metabolic effects of selective activation of a G(q)-coupled receptor in hepatocytes in vivo.Resolving Behavioral Output via Chemogenetic Designer Receptors Exclusively Activated by Designer DrugsNovel insights into M3 muscarinic acetylcholine receptor physiology and structure.New tricks for old dogmas: optogenetic and designer receptor insights for Parkinson's diseaseTuning up the right signal: chemical and genetic approaches to study GPCR functions.Muscarinic acetylcholine receptors: novel opportunities for drug development.Molecular approaches for manipulating astrocytic signaling in vivo.Minireview: Role of intracellular scaffolding proteins in the regulation of endocrine G protein-coupled receptor signaling.Chemogenetic Modulation of G Protein-Coupled Receptor Signalling in Visual Attention Research.The Viral G Protein-Coupled Receptor ORF74 Hijacks β-Arrestins for Endocytic Trafficking in Response to Human Chemokines.Use of Designer G Protein-Coupled Receptors to Dissect Metabolic Pathways.Characterization of three vasopressin receptor 2 variants: an apparent polymorphism (V266A) and two loss-of-function mutations (R181C and M311V)DREADD: a chemogenetic GPCR signaling platformEye-Drops for Activation of DREADDs.Evolutionary action and structural basis of the allosteric switch controlling β2AR functional selectivity.Biased signalling: from simple switches to allosteric microprocessors.The use of chemogenetics in behavioural neuroscience: Receptor variants, targeting approaches, and caveats.Optogenetics and pharmacogenetics: principles and applications.Lack of beta-arrestin signaling in the absence of active G proteins.Chemogenetic Tools for Causal Cellular and Neuronal Biology.Hepatic Gi signaling regulates whole-body glucose homeostasis.
P2860
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P2860
Design and functional characterization of a novel, arrestin-biased designer G protein-coupled receptor.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Design and functional characte ...... er G protein-coupled receptor.
@ast
Design and functional characte ...... er G protein-coupled receptor.
@en
type
label
Design and functional characte ...... er G protein-coupled receptor.
@ast
Design and functional characte ...... er G protein-coupled receptor.
@en
prefLabel
Design and functional characte ...... er G protein-coupled receptor.
@ast
Design and functional characte ...... er G protein-coupled receptor.
@en
P2860
P356
P1476
Design and functional characte ...... er G protein-coupled receptor.
@en
P2093
Jürgen Wess
Ken-ichiro Nakajima
P2860
P304
P356
10.1124/MOL.112.080358
P577
2012-07-20T00:00:00Z