Expanded GAA repeats impede transcription elongation through the FXN gene and induce transcriptional silencing that is restricted to the FXN locus.

Expanded GAA repeats impede transcription elongation through the FXN gene and induce transcriptional silencing that is restricted to the FXN locus.

Item
http://www.wikidata.org/entity/Q36302082
Activating frataxin expression by repeat-targeted nucleic acidsReversal of epigenetic promoter silencing in Friedreich ataxia by a class I histone deacetylase inhibitor.Stalled DNA Replication Forks at the Endogenous GAA Repeats Drive Repeat Expansion in Friedreich's Ataxia Cells.E3 Ligase RNF126 Directly Ubiquitinates Frataxin, Promoting Its Degradation: Identification of a Potential Therapeutic Target for Friedreich Ataxia.The Replication of Frataxin Gene Is Assured by Activation of Dormant Origins in the Presence of a GAA-Repeat Expansion.Establishment and Maintenance of Primary Fibroblast Repositories for Rare Diseases-Friedreich's Ataxia Example.Translating HDAC inhibitors in Friedreich's ataxia.Close encounters: Moving along bumps, breaks, and bubbles on expanded trinucleotide tracts.Deep sequencing of mitochondrial genomes reveals increased mutation load in Friedreich's ataxia.Comprehensive analysis of gene expression patterns in Friedreich's ataxia fibroblasts by RNA sequencing reveals altered levels of protein synthesis factors and solute carriers.Inducible and reversible phenotypes in a novel mouse model of Friedreich's Ataxia.Somatic instability of the expanded GAA repeats in Friedreich's ataxia.Synthetic transcription elongation factors license transcription across repressive chromatin.Alleviating GAA Repeat Induced Transcriptional Silencing of the Friedreich's Ataxia Gene During Somatic Cell Reprogramming.
P2860

Expanded GAA repeats impede transcription elongation through the FXN gene and induce transcriptional silencing that is restricted to the FXN locus.

Item
http://www.wikidata.org/entity/Q36302082
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Expanded GAA repeats impede tr ...... s restricted to the FXN locus.
@ast
Expanded GAA repeats impede tr ...... s restricted to the FXN locus.
@en
type
label
Expanded GAA repeats impede tr ...... s restricted to the FXN locus.
@ast
Expanded GAA repeats impede tr ...... s restricted to the FXN locus.
@en
prefLabel
Expanded GAA repeats impede tr ...... s restricted to the FXN locus.
@ast
Expanded GAA repeats impede tr ...... s restricted to the FXN locus.
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P698
P921
P932
P356
P1433
P1476
Expanded GAA repeats impede tr ...... s restricted to the FXN locus.
@en
P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P698
P921
P932