Mechanisms of protein fibril formation: nucleated polymerization with competing off-pathway aggregation
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The 8 and 5 kDa fragments of plasma gelsolin form amyloid fibrils by a nucleated polymerization mechanism, while the 68 kDa fragment is not amyloidogenicA single mutation in the nonamyloidogenic region of islet amyloid polypeptide greatly reduces toxicityAmyloid formation in light chain amyloidosisFragmentation and Coagulation in Supramolecular (Co)polymerization KineticsHydrogen sulfide inhibits amyloid formationStructural Alterations within Native Amyloidogenic Immunoglobulin Light ChainsIdentification of fibrillogenic regions in human triosephosphate isomerase.Ultrasonic force microscopy for nanomechanical characterization of early and late-stage amyloid-β peptide aggregation.Mechanistic and environmental control of the prevalence and lifetime of amyloid oligomersModel discrimination and mechanistic interpretation of kinetic data in protein aggregation studies.Role of small oligomers on the amyloidogenic aggregation free-energy landscapeIn vitro aggregation behavior of a non-amyloidogenic λ light chain dimer deriving from U266 multiple myeloma cells.Atomic-resolution dynamics on the surface of amyloid-β protofibrils probed by solution NMRAmyloid beta-protein dimers rapidly form stable synaptotoxic protofibrils.A mechanistic model for amorphous protein aggregation of immunoglobulin-like domains.What drives amyloid molecules to assemble into oligomers and fibrils?A micellar on-pathway intermediate step explains the kinetics of prion amyloid formationA setup for simultaneous measurement of infrared spectra and light scattering signals: watching amyloid fibrils grow from intact proteins.Gelsolin Amyloidogenesis Is Effectively Modulated by Curcumin and Emetine Conjugated PLGA Nanoparticles.Self-Assembly of Aβ40, Aβ42 and Aβ43 Peptides in Aqueous Mixtures of Fluorinated Alcohols.Dissecting the kinetic process of amyloid fiber formation through asymptotic analysis.Reverse engineering an amyloid aggregation pathway with dimensional analysis and scaling.A Kinetic Model for Cell Damage Caused by Oligomer Formation.A lattice-gas model for amyloid fibril aggregation.Monomeric Aβ(1-40) and Aβ(1-42) Peptides in Solution Adopt Very Similar Ramachandran Map Distributions That Closely Resemble Random Coil.Simple moment-closure model for the self-assembly of breakable amyloid filaments.Determination of critical nucleation number for a single nucleation amyloid-β aggregation model.Effects of Charged Cholesterol Derivatives on Aβ40 Amyloid Formation.Site-specific modification of Alzheimer's peptides by cholesterol oxidation products enhances aggregation energetics and neurotoxicityMechanisms of amyloid fibril formation--focus on domain-swapping.Gelsolin amyloidosis: genetics, biochemistry, pathology and possible strategies for therapeutic intervention.Statistical mechanical treatments of protein amyloid formation.Glucose directs amyloid-beta into membrane-active oligomers.Differences in Protein Concentration Dependence for Nucleation and Elongation in Light Chain Amyloid Formation.Non-equilibrium supramolecular polymerization.Glycerol inhibits the primary pathways and transforms the secondary pathway of insulin aggregation.A peptidomimetic approach to targeting pre-amyloidogenic states in type II diabetesNucleated polymerization with secondary pathways. II. Determination of self-consistent solutions to growth processes described by non-linear master equations.Fatty Acid Concentration and Phase Transitions Modulate Aβ Aggregation Pathways.A kinetic aggregation assay allowing selective and sensitive amyloid-β quantification in cells and tissues.
P2860
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P2860
Mechanisms of protein fibril formation: nucleated polymerization with competing off-pathway aggregation
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
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2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
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2007年學術文章
@zh-hant
name
Mechanisms of protein fibril f ...... peting off-pathway aggregation
@ast
Mechanisms of protein fibril f ...... peting off-pathway aggregation
@en
type
label
Mechanisms of protein fibril f ...... peting off-pathway aggregation
@ast
Mechanisms of protein fibril f ...... peting off-pathway aggregation
@en
prefLabel
Mechanisms of protein fibril f ...... peting off-pathway aggregation
@ast
Mechanisms of protein fibril f ...... peting off-pathway aggregation
@en
P2860
P1433
P1476
Mechanisms of protein fibril f ...... peting off-pathway aggregation
@en
P2093
David L Powers
Evan T Powers
P2860
P304
P356
10.1529/BIOPHYSJ.107.117168
P407
P577
2007-09-21T00:00:00Z