Cyclin D2 rescues size and function of GATA4 haplo-insufficient hearts
about
Transcriptome analysis of tetraploid cells identifies cyclin D2 as a facilitator of adaptation to genome doubling in the presence of p53Disruption of myocardial Gata4 and Tbx5 results in defects in cardiomyocyte proliferation and atrioventricular septation.Redox regulation of cardiomyocyte cell cycling via an ERK1/2 and c-Myc-dependent activation of cyclin D2 transcriptionASK1 mediates the teratogenicity of diabetes in the developing heart by inducing ER stress and inhibiting critical factors essential for cardiac development.Silencing of TBX20 gene expression in rat myocardial and human embryonic kidney cells leads to cell cycle arrest in G2 phaseCyclin D2 is a GATA4 cofactor in cardiogenesis.Quercetin reduces cyclin D1 activity and induces G1 phase arrest in HepG2 cells.Novel exons in the tbx5 gene locus generate protein isoforms with distinct expression domains and function.Caspase-1 cleavage of transcription factor GATA4 and regulation of cardiac cell fate.KLF13 is a genetic modifier of the Holt-Oram syndrome gene TBX5.Muscle connective tissue controls development of the diaphragm and is a source of congenital diaphragmatic hernias.Single cardiomyocyte nuclear transcriptomes reveal a lincRNA-regulated de-differentiation and cell cycle stress-response in vivo.
P2860
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P2860
Cyclin D2 rescues size and function of GATA4 haplo-insufficient hearts
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Cyclin D2 rescues size and function of GATA4 haplo-insufficient hearts
@ast
Cyclin D2 rescues size and function of GATA4 haplo-insufficient hearts
@en
type
label
Cyclin D2 rescues size and function of GATA4 haplo-insufficient hearts
@ast
Cyclin D2 rescues size and function of GATA4 haplo-insufficient hearts
@en
prefLabel
Cyclin D2 rescues size and function of GATA4 haplo-insufficient hearts
@ast
Cyclin D2 rescues size and function of GATA4 haplo-insufficient hearts
@en
P2093
P2860
P1476
Cyclin D2 rescues size and function of GATA4 haplo-insufficient hearts
@en
P2093
Abir Yamak
Anne Aries
Pierre Paradis
Rana Temsah
Sophie Caron
Wael Maharsy
P2860
P304
P356
10.1152/AJPHEART.00250.2012
P50
P577
2012-08-24T00:00:00Z