Gelsolin deficiency blocks podosome assembly and produces increased bone mass and strength.
about
The architecture of the adhesive apparatus of cultured osteoclasts: from podosome formation to sealing zone assemblyDirect dynamin-actin interactions regulate the actin cytoskeleton.Regulation of cell motility by tyrosine phosphorylated villinTks5-dependent formation of circumferential podosomes/invadopodia mediates cell-cell fusionL-plastin nanobodies perturb matrix degradation, podosome formation, stability and lifetime in THP-1 macrophagesPodosomes display actin turnover and dynamic self-organization in osteoclasts expressing actin-green fluorescent protein.Gelsolin and ADF/cofilin enhance the actin dynamics of motile cellsRegulation of the formation of osteoclastic actin rings by proline-rich tyrosine kinase 2 interacting with gelsolinPolyphosphoinositides-dependent regulation of the osteoclast actin cytoskeleton and bone resorptionRegulation of osteoclasts by membrane-derived lipid mediatorsGelsolin-independent podosome formation in dendritic cellsPhosphatidylinositol 3,4,5-trisphosphate directs association of Src homology 2-containing signaling proteins with gelsolinSpatiotemporal regulation of Src and its substrates at invadosomesNa+-dependent phosphate transporters in the murine osteoclast: cellular distribution and protein interactionsDramatic inhibition of osteoclast sealing ring formation and bone resorption in vitro by a WASP-peptide containing pTyr294 amino acidActive Rho is localized to podosomes induced by oncogenic Src and is required for their assembly and function.Metastasis suppressor proteins: discovery, molecular mechanisms, and clinical applicationCortactin has an essential and specific role in osteoclast actin assemblySyk-dependent actin dynamics regulate endocytic trafficking and processing of antigens internalized through the B-cell receptorErk1/2 MAPK and caldesmon differentially regulate podosome dynamics in A7r5 vascular smooth muscle cells.Supervillin reorganizes the actin cytoskeleton and increases invadopodial efficiency.Analysis of the signaling pathways regulating Src-dependent remodeling of the actin cytoskeleton.Gelsolin induces colorectal tumor cell invasion via modulation of the urokinase-type plasminogen activator cascadePrognostic significance of MCM2, Ki-67 and gelsolin in non-small cell lung cancerStructural and mechanical functions of integrins.Osteosarcoma is characterised by reduced expression of markers of osteoclastogenesis and antigen presentation compared with normal boneIs GSN significant for hip BMD in female Caucasians?Phosphatidylinositol 3-kinases in tumor progression.Regulation of sealing ring formation by L-plastin and cortactin in osteoclasts.Integrin alpha V beta 3 as a target for treatment of rheumatoid arthritis and related rheumatic diseases.The actin binding protein adseverin regulates osteoclastogenesisThe loss of Cbl-phosphatidylinositol 3-kinase interaction perturbs RANKL-mediated signaling, inhibiting bone resorption and promoting osteoclast survival.Podosome organization drives osteoclast-mediated bone resorption.Stimulation of actin polymerization by filament severingAdseverin knockdown inhibits osteoclastogenesis in RAW264.7 cellsCofilin activation during podosome belt formation in osteoclastsOsteopontin deficiency produces osteoclast dysfunction due to reduced CD44 surface expression.A Drosophila model of multiple endocrine neoplasia type 2.Gelsolin is a dorsalizing factor in zebrafishCaldesmon as a therapeutic target for proliferative vascular diseases.
P2860
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P2860
Gelsolin deficiency blocks podosome assembly and produces increased bone mass and strength.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
2000年學術文章
@zh
2000年學術文章
@zh-hant
name
Gelsolin deficiency blocks pod ...... reased bone mass and strength.
@ast
Gelsolin deficiency blocks pod ...... reased bone mass and strength.
@en
type
label
Gelsolin deficiency blocks pod ...... reased bone mass and strength.
@ast
Gelsolin deficiency blocks pod ...... reased bone mass and strength.
@en
prefLabel
Gelsolin deficiency blocks pod ...... reased bone mass and strength.
@ast
Gelsolin deficiency blocks pod ...... reased bone mass and strength.
@en
P2093
P2860
P356
P1476
Gelsolin deficiency blocks pod ...... reased bone mass and strength.
@en
P2093
P2860
P304
P356
10.1083/JCB.148.4.665
P407
P577
2000-02-01T00:00:00Z