In Vitro Metabolism of Montelukast by Cytochrome P450s and UDP-Glucuronosyltransferases

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Clopidogrel but Not Prasugrel Significantly Inhibits the CYP2C8-Mediated Metabolism of Montelukast in Humans.Comprehensive Pharmacogenomic Study Reveals an Important Role of UGT1A3 in Montelukast Pharmacokinetics.Everolimus-inhibited multiple isoforms of UDP-glucuronosyltransferases (UGTs).

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In Vitro Metabolism of Montelukast by Cytochrome P450s and UDP-Glucuronosyltransferases

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http://www.wikidata.org/entity/Q36316466

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2015 nî lūn-bûn

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2015年の論文

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2015年学术文章

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2015年学术文章

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2015年学术文章

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2015年学术文章

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2015年學術文章

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2015年學術文章

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name

In Vitro Metabolism of Montelukast by Cytochrome P450s and UDP-Glucuronosyltransferases

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In Vitro Metabolism of Montelukast by Cytochrome P450s and UDP-Glucuronosyltransferases

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type

Item

label

In Vitro Metabolism of Montelukast by Cytochrome P450s and UDP-Glucuronosyltransferases

@ast

In Vitro Metabolism of Montelukast by Cytochrome P450s and UDP-Glucuronosyltransferases

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prefLabel

In Vitro Metabolism of Montelukast by Cytochrome P450s and UDP-Glucuronosyltransferases

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In Vitro Metabolism of Montelukast by Cytochrome P450s and UDP-Glucuronosyltransferases

@en

P1476

In Vitro Metabolism of Montelukast by Cytochrome P450s and UDP-Glucuronosyltransferases

@en

P2093

Jessica Bo Li Lu

http://www.w3.org/2001/XMLSchema#string

Josiane de Oliveira Cardoso

http://www.w3.org/2001/XMLSchema#string

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Determinants of Cytochrome P450 2C8 Substrate Binding: STRUCTURES OF COMPLEXES WITH MONTELUKAST, TROGLITAZONE, FELODIPINE, AND 9-CIS-RETINOIC ACID

Quantification of montelukast, a selective cysteinyl leukotriene receptor (CysLT1) antagonist in human plasma by liquid chromatography-mass spectrometry: validation and its application to a human pharmacokinetic study.

Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP2/OATP1B1:SLC21A6)-mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin: analysis of the mechanism of the clinically relevant drug-drug inter

CYP2C8 but not CYP3A4 is important in the pharmacokinetics of montelukast.

Intestinal UGTs as potential modifiers of pharmacokinetics and biological responses to drugs and xenobiotics.

Absorption of montelukast is transporter mediated: a common variant of OATP2B1 is associated with reduced plasma concentrations and poor response.

Leukotrienes and other products of the 5-lipoxygenase pathway. Biochemistry and relation to pathobiology in human diseases.

Effect of clarithromycin and fluconazole on the pharmacokinetics of montelukast in human volunteers.

Substrate-dependent drug-drug interactions between gemfibrozil, fluvastatin and other organic anion-transporting peptide (OATP) substrates on OATP1B1, OATP2B1, and OATP1B3.

Properties of acyl glucuronides: implications for studies of the pharmacokinetics and metabolism of acidic drugs.

P304

1905-1916

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P31

scholarly article

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10.1124/DMD.115.065763

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English

P433

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

P50

Regina V. Oliveira

Zeruesenay Desta

P577

2015-12-01T00:00:00Z

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P698

26374173

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P932

4658491

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In Vitro Metabolism of Montelukast by Cytochrome P450s and UDP-Glucuronosyltransferases

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P2860

P2860

In Vitro Metabolism of Montelukast by Cytochrome P450s and UDP-Glucuronosyltransferases

description

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type

label

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P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698

P932