Evidence that the nucleotide exchange and hydrolysis cycle of G proteins causes acute desensitization of G-protein gated inward rectifier K+ channels
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Cytoplasmic, nuclear, and golgi localization of RGS proteins. Evidence for N-terminal and RGS domain sequences as intracellular targeting motifsAlternative splicing of RGS8 gene determines inhibitory function of receptor type-specific Gq signalingMotor coordination deficits in mice lacking RGS9Gene-trapped mouse embryonic stem cell-derived cardiac myocytes and human genetics implicate AKAP10 in heart rhythm regulationRestoring the ON Switch in Blind Retinas: Opto-mGluR6, a Next-Generation, Cell-Tailored Optogenetic ToolRGS7 and RGS8 differentially accelerate G protein-mediated modulation of K+ currentsPalmitoylation of a conserved cysteine in the regulator of G protein signaling (RGS) domain modulates the GTPase-activating activity of RGS4 and RGS10RGS9 proteins facilitate acute tolerance to mu-opioid effectsR7BP augments the function of RGS7*Gbeta5 complexes by a plasma membrane-targeting mechanismInteraction between the RGS domain of RGS4 with G protein alpha subunits mediates the voltage-dependent relaxation of the G protein-gated potassium channelPalmitoylation regulates plasma membrane-nuclear shuttling of R7BP, a novel membrane anchor for the RGS7 family.Regulators of G Protein SignalingActivation and inhibition of G protein-coupled inwardly rectifying potassium (Kir3) channels by G protein beta gamma subunits.Depletion of phosphatidylinositol 4,5-bisphosphate by activation of phospholipase C-coupled receptors causes slow inhibition but not desensitization of G protein-gated inward rectifier K+ current in atrial myocytes.Membrane anchor R9AP potentiates GTPase-accelerating protein activity of RGS11 x Gbeta5 complex and accelerates inactivation of the mGluR6-G(o) signaling.What molecular events underlie heterologous desensitization? Focus on "receptor phosphorylation does not mediate cross talk between muscarinic M(3) and bradykinin B(2) receptors".G-protein mediated gating of inward-rectifier K+ channels.Receptor-induced depletion of phosphatidylinositol 4,5-bisphosphate inhibits inwardly rectifying K+ channels in a receptor-specific mannerDesensitization of mu-opioid receptor-evoked potassium currents: initiation at the receptor, expression at the effector.Graded contribution of the Gbeta gamma binding domains to GIRK channel activation.Uncoupling conformational change from GTP hydrolysis in a heterotrimeric G protein alpha-subunit.The complex and intriguing lives of PIP2 with ion channels and transporters.Agonist unbinding from receptor dictates the nature of deactivation kinetics of G protein-gated K+ channelsRegulation of the muscarinic K+ channel by extracellular ATP through membrane phosphatidylinositol 4,5-bisphosphate in guinea-pig atrial myocytesPleiotropic phenotype of a genomic knock-in of an RGS-insensitive G184S Gnai2 alleleRegulators of G protein signalling: potential targets for treatment of allergic inflammatory diseases such as asthma.Mu-opioid receptor desensitization: is morphine different?G-protein signaling: back to the futureRapid GTP binding and hydrolysis by G(q) promoted by receptor and GTPase-activating proteins.GIRK channel modulation by assembly with allosterically regulated RGS proteinsIncreased agonist affinity at the μ-opioid receptor induced by prolonged agonist exposure.Coordinating speed and amplitude in G-protein signaling.Addictive drugs modulate GIRK-channel signaling by regulating RGS proteinsRegulator of G-protein signalling and GoLoco proteins suppress TRPC4 channel function via acting at Gαi/o.Neuropeptide transmission in brain circuits.Computational modeling reveals how interplay between components of a GTPase-cycle module regulates signal transductionG protein modulation of recombinant P/Q-type calcium channels by regulators of G protein signalling proteins.New roles for RGS2, 5 and 8 on the ratio-dependent modulation of recombinant GIRK channels expressed in Xenopus oocytes.Untangling ligand induced activation and desensitization of G-protein-coupled receptors.Differential effects of melatonin and its downstream effector PKCalpha on subcellular localization of RGS proteins.
P2860
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P2860
Evidence that the nucleotide exchange and hydrolysis cycle of G proteins causes acute desensitization of G-protein gated inward rectifier K+ channels
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
Evidence that the nucleotide e ...... d inward rectifier K+ channels
@ast
Evidence that the nucleotide e ...... d inward rectifier K+ channels
@en
type
label
Evidence that the nucleotide e ...... d inward rectifier K+ channels
@ast
Evidence that the nucleotide e ...... d inward rectifier K+ channels
@en
prefLabel
Evidence that the nucleotide e ...... d inward rectifier K+ channels
@ast
Evidence that the nucleotide e ...... d inward rectifier K+ channels
@en
P2093
P2860
P356
P1476
Evidence that the nucleotide e ...... d inward rectifier K+ channels
@en
P2093
P2860
P304
11727-11732
P356
10.1073/PNAS.95.20.11727
P407
P577
1998-09-01T00:00:00Z