Critical roles for the COOH-terminal NITY and RGT sequences of the integrin beta3 cytoplasmic domain in inside-out and outside-in signaling
about
Calpain-mediated degradation of reversibly oxidized protein-tyrosine phosphatase 1BIP-10 induces dissociation of newly formed blood vesselsStructure and function of the platelet integrin alphaIIbbeta3The proteoglycan brevican binds to fibronectin after proteolytic cleavage and promotes glioma cell motilityPost-translational modification-regulated leukocyte adhesion and migrationSequential activation of p38 and ERK pathways by cGMP-dependent protein kinase leading to activation of the platelet integrin alphaIIb beta3Platelet integrin alpha(IIb)beta(3): activation mechanismsKindlin-2 controls bidirectional signaling of integrinsRGT, a synthetic peptide corresponding to the integrin beta 3 cytoplasmic C-terminal sequence, selectively inhibits outside-in signaling in human platelets by disrupting the interaction of integrin alpha IIb beta 3 with Src kinase.Missense mutations in the ABCB6 transporter cause dominant familial pseudohyperkalemia.Calpain-mediated proteolysis of paxillin negatively regulates focal adhesion dynamics and cell migration.A directional switch of integrin signalling and a new anti-thrombotic strategy.Inhibition of platelet activation by peptide analogs of the beta(3)-intracellular domain of platelet integrin alpha(IIb)beta(3) conjugated to the cell-penetrating peptide Tat(48-60).Direct interaction of kindlin-3 with integrin αIIbβ3 in platelets is required for supporting arterial thrombosis in mice.Spatial coordination of kindlin-2 with talin head domain in interaction with integrin β cytoplasmic tailsCalpain is required for normal osteoclast function and is down-regulated by calcitoninEvaluation of targeting c-Src by the RGT-containing peptide as a novel antithrombotic strategy.A molecular switch that controls cell spreading and retraction.The interaction of Gα13 with integrin β1 mediates cell migration by dynamic regulation of RhoAFunctional Effect of the Mutations Similar to the Cleavage during Platelet Activation at Integrin β3 Cytoplasmic Tail when Expressed in Mouse PlateletsIncreased extracellular pressure enhances cancer cell integrin-binding affinity through phosphorylation of beta1-integrin at threonine 788/789Antithrombotic effects of targeting alphaIIbbeta3 signaling in platelets.Mitochondrially mediated integrin αIIbβ3 protein inactivation limits thrombus growth.Platelet adhesion and activation mechanisms in arterial thrombosis and ischaemic stroke.LFA-1 fine-tuning by cathepsin X.Model systems for platelet receptor shedding.A mutation in the β3 cytoplasmic tail causes variant Glanzmann thrombasthenia by abrogating transition of αIIb β3 to an active state.Kindlin-2 (Mig-2): a co-activator of beta3 integrins.Integrin alphaIIb-subunit cytoplasmic domain mutations demonstrate a requirement for tyrosine phosphorylation of beta3-subunits in actin cytoskeletal organization.A platelet secretion pathway mediated by cGMP-dependent protein kinase.Specification of the direction of adhesive signaling by the integrin beta cytoplasmic domain.Cooperative role of the membrane-proximal and -distal residues of the integrin beta3 cytoplasmic domain in regulation of talin-mediated alpha IIb beta3 activation.Roles of integrin β3 cytoplasmic tail in bidirectional signal transduction in a trans-dominant inhibition model.Fibrinogen interaction of CHO cells expressing chimeric alphaIIb/alphavbeta3 integrin.Pathological shear stress directly regulates platelet alphaIIbbeta3 signaling.Tyrosine phosphorylation of the integrin beta 3 subunit regulates beta 3 cleavage by calpain.
P2860
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P2860
Critical roles for the COOH-terminal NITY and RGT sequences of the integrin beta3 cytoplasmic domain in inside-out and outside-in signaling
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
Critical roles for the COOH-te ...... e-out and outside-in signaling
@ast
Critical roles for the COOH-te ...... e-out and outside-in signaling
@en
type
label
Critical roles for the COOH-te ...... e-out and outside-in signaling
@ast
Critical roles for the COOH-te ...... e-out and outside-in signaling
@en
prefLabel
Critical roles for the COOH-te ...... e-out and outside-in signaling
@ast
Critical roles for the COOH-te ...... e-out and outside-in signaling
@en
P2093
P2860
P356
P1476
Critical roles for the COOH-te ...... e-out and outside-in signaling
@en
P2093
Richard J Bodnar
Stephen C-T Lam
Xiaodong Xi
Xiaoping Du
P2860
P304
P356
10.1083/JCB.200303120
P407
P577
2003-07-14T00:00:00Z