Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment. - Wikidata - awgldk - TriplyDB

Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment.

Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment.

http://www.wikidata.org/entity/Q36342774

about

Protein disulfide isomerase a multifunctional protein with multiple physiological roles A substrate-driven allosteric switch that enhances PDI catalytic activity Research perspective: potential role of nitazoxanide in ovarian cancer treatment. Old drug, new purpose?Radicol, a Novel Trinorguaiane-Type Sesquiterpene, Induces Temozolomide-Resistant Glioma Cell Apoptosis via ER Stress and Akt/mTOR Pathway Blockade.Thiol isomerases in thrombus formation.A novel prognostic factor for hepatocellular carcinoma: protein disulfide isomerase.Protein Disulfide Isomerase Superfamily in Disease and the Regulation of Apoptosis Small molecule-induced oxidation of protein disulfide isomerase is neuroprotective.Therapeutic implications of protein disulfide isomerase inhibition in thrombotic disease.Mechanisms of Translocation of ER Chaperones to the Cell Surface and Immunomodulatory Roles in Cancer and Autoimmunity.Analysis of the isomerase and chaperone-like activities of an amebic PDI (EhPDI).A small molecule inhibits protein disulfide isomerase and triggers the chemosensitization of cancer cells.Novel roles for protein disulphide isomerase in disease states: a double edged sword?Bruton's tyrosine kinase (Btk) inhibitor ibrutinib suppresses stem-like traits in ovarian cancer.Platelet-targeting thiol reduction sensor detects thiol isomerase activity on activated platelets in mouse and human blood under flow Oxidation of heat shock protein 60 and protein disulfide isomerase activates ERK and migration of human hepatocellular carcinoma HepG2.Standardized Profiling of The Membrane-Enriched Proteome of Mouse Dorsal Root Ganglia (DRG) Provides Novel Insights Into Chronic Pain.Broad-spectrum antivirals against viral fusion.Pharmacokinetics and antitumor efficacy of DSPE-PEG2000 polymeric liposomes loaded with quercetin and temozolomide: Analysis of their effectiveness in enhancing the chemosensitization of drug-resistant glioma cells.Dimeric peroxiredoxins are druggable targets in human Burkitt lymphoma.Protein disulfide isomerase as an antithrombotic target Mechanistic evaluation and transcriptional signature of a glutathione S-transferase omega 1 inhibitor EF24 prevents rotenone-induced estrogenic status alteration in breast cancer.The protein disulfide isomerases PDIA4 and PDIA6 mediate resistance to cisplatin-induced cell death in lung adenocarcinoma.Worming our way to novel drug discovery with the Caenorhabditis elegans proteostasis network, stress response and insulin-signaling pathways.Methods of measuring protein disulfide isomerase activity: a critical overview.Targeting the unfolded protein response for disease intervention.PDI is an essential redox-sensitive activator of PERK during the unfolded protein response (UPR)Early-onset torsion dystonia: a novel high-throughput yeast genetic screen for factors modifying protein levels of torsinAΔE.Depletion of the thiol oxidoreductase ERp57 in tumor cells inhibits proliferation and increases sensitivity to ionizing radiation and chemotherapeutics Dual inhibition of survivin and MAOA synergistically impairs growth of PTEN-negative prostate cancer.Live cell off-target identification of lapatinib using ligand-directed tosyl chemistry.Proteomic analysis identifies proteins associated with curcumin-enhancing efficacy of irinotecan-induced apoptosis of colorectal cancer LOVO cell Advances in vascular thiol isomerase function.Mia40 is a facile oxidant of unfolded reduced proteins but shows minimal isomerase activity.A new antithrombotic strategy: inhibition of the C-terminal active site of protein disulfide isomerase.An arsenical-maleimide for the generation of new targeted biochemical reagents.Armet/Manf and Creld2 are components of a specialized ER stress response provoked by inappropriate formation of disulphide bonds: implications for genetic skeletal diseases.Emerging roles of protein disulfide isomerase in cancer.The dehydrogenase region of the NADPH oxidase component Nox2 acts as a protein disulfide isomerase (PDI) resembling PDIA3 with a role in the binding of the activator protein p67 (phox.).

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P2860

Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment.

http://www.wikidata.org/entity/Q36342774

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2012 nî lūn-bûn

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Discovery of an orally active ...... for ovarian cancer treatment.

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Discovery of an orally active ...... for ovarian cancer treatment.

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PNAS.1205226109

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Proceedings of the National Academy of Sciences of the United States of America

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Discovery of an orally active ...... for ovarian cancer treatment.

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Alexey N Butkevich

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Bikash Debnath

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Ebrahim Zandi

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Nicos A Petasis

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Nouri Neamati

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Roger Duncan

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Roppei Yamada

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Shili Xu

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Yu Zhou

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P2860

Structure determination of the N-terminal thioredoxin-like domain of protein disulfide isomerase using multidimensional heteronuclear 13C/15N NMR spectroscopy

Cancer statistics, 2012

S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration

Expression and site-directed mutagenesis of human protein disulfide isomerase in Escherichia coli. This multifunctional polypeptide has two independently acting catalytic sites for the isomerase activity

Disulfide bonds in ER protein folding and homeostasis

Gene-expression profiles predict survival of patients with lung adenocarcinoma

Reverse engineering of regulatory networks in human B cells

K2D2: estimation of protein secondary structure from circular dichroism spectra.

Protein disulfide isomerases are antibody targets during immune-mediated tumor destruction.

Tissue-specific pathways for estrogen regulation of ovarian cancer growth and metastasis

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109

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