Gene complementation. Neither Ir-GLphi gene need be present in the proliferative T cell to generate an immune response to Poly(Glu55Lys36Phe9)n.
about
Inhibition of antigen-induced proliferation of T cells from radiation-induced bone marrow chimeras by a monoclonal antibody directed against an Ia determinant on the antigen-presenting cell.A novel type of T-T cell interaction removes the requirement for I-B region in the H-2 complexMonoclonal antibody against an Ir gene product?Antigen-reactive T cell clones. II. Unique homozygous and (high responder x low responder)F1 hybrid antigen-presenting determinants detected using poly(Tyr, Glu)-poly D, L-Ala--poly Lys-reactive T cell clones.Antigen-specific T cell clones restricted to unique F1 major histocompatibility complex determinants. Inhibition of proliferation with monoclonal anti-Ia antibodyResponder T cells depleted of alloreactive cells react to antigen presented on allogeneic macrophages from nonresponder strains.Murine syngeneic mixed lymphocyte response. I. Target antigens are self Ia moleculesImmune response gene function correlates with the expression of an Ia antigen. II. A quantitative deficiency in Ae:E alpha complex expression causes a corresponding defect in antigen-presenting cell function.Studies of defective tolerance induction in NZB mice. Evidence for a marrow pre-T cell defectSelf-recognition specificity expressed by T cells from nude mice. Absence of detectable Ia-restricted T cells in nude mice that do exhibit self-K/D-restricted T cell responses.Unresponsiveness to a self-peptide of mouse lysozyme owing to hindrance of T cell receptor-major histocompatibility complex/peptide interaction caused by flanking epitopic residuesBone marrow-derived thymic antigen-presenting cells determine self-recognition of Ia-restricted T lymphocytes.Functional clonal deletion of cytotoxic T-lymphocyte precursors in chimeric thymus produced in vitro from embryonic Anlagen.Antigen-specific, proliferating T lymphocyte clones. Methodology, specificity, MHC restriction and alloreactivity.Murine T lymphocyte clones with distinct immunological functions.Ia antigens as restriction molecules in Ir-gene controlled T-cell proliferation.Effects of blocking helper T cell induction in vivo with anti-Ia antibodies. Possible role of I-A/E hybrid molecules as restriction elements.Role of the H-2 complex in induction of T helper cells in vivo. III. Contribution of the I-E subregion to restriction sites recognized by I-A/E-restricted T cells.Role of the H-2 complex in induction of T helper cells in vivo. II Negative selection of discrete subgroups of T cells restricted by I-A and I-A/E determinants.
P2860
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P2860
Gene complementation. Neither Ir-GLphi gene need be present in the proliferative T cell to generate an immune response to Poly(Glu55Lys36Phe9)n.
description
1980 nî lūn-bûn
@nan
1980年の論文
@ja
1980年学术文章
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1980年学术文章
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1980年学术文章
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1980年学术文章
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1980年学术文章
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1980年學術文章
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name
Gene complementation. Neither ...... onse to Poly(Glu55Lys36Phe9)n.
@ast
Gene complementation. Neither ...... onse to Poly(Glu55Lys36Phe9)n.
@en
type
label
Gene complementation. Neither ...... onse to Poly(Glu55Lys36Phe9)n.
@ast
Gene complementation. Neither ...... onse to Poly(Glu55Lys36Phe9)n.
@en
prefLabel
Gene complementation. Neither ...... onse to Poly(Glu55Lys36Phe9)n.
@ast
Gene complementation. Neither ...... onse to Poly(Glu55Lys36Phe9)n.
@en
P2860
P356
P1476
Gene complementation. Neither ...... onse to Poly(Glu55Lys36Phe9)n.
@en
P2093
P2860
P304
P356
10.1084/JEM.151.6.1452
P407
P577
1980-06-01T00:00:00Z