ATP release and purinergic signaling: a common pathway for particle-mediated inflammasome activation - Wikidata - awgldk - TriplyDB

ATP release and purinergic signaling: a common pathway for particle-mediated inflammasome activation

ATP release and purinergic signaling: a common pathway for particle-mediated inflammasome activation

http://www.wikidata.org/entity/Q36347237

about

The complex cascade of cellular events governing inflammasome activation and IL-1β processing in response to inhaled particles Inflammasome, IL-1 and inflammation in ozone-induced lung injury Molecular mechanisms regulating NLRP3 inflammasome activation Purinergic signaling and human immunodeficiency virus/acquired immune deficiency syndrome: From viral entry to therapy Regulation of Dendritic Cell Function in Inflammation Reactive oxygen species at the crossroads of inflammasome and inflammation Role of connexin/pannexin containing channels in infectious diseases The role of pannexin hemichannels in inflammation and regeneration The NLRP3 inflammasome in pathogenic particle and fibre-associated lung inflammation and diseases Initiation and perpetuation of NLRP3 inflammasome activation and assembly The dendritic cell response to classic, emerging, and homeostatic danger signals. Implications for autoimmunity A co-culture system with an organotypic lung slice and an immortal alveolar macrophage cell line to quantify silica-induced inflammation The role of pannexin1 in the induction and resolution of inflammation.P2X-selective purinergic antagonists are strong inhibitors of HIV-1 fusion during both cell-to-cell and cell-free infection.Danger signals - damaged-self recognition across the tree of life.Adenosine-5'-triphosphate (ATP) protects mice against bacterial infection by activation of the NLRP3 inflammasome.Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity.Particle size of latex beads dictates IL-1β production mechanism.IL-1β and IL-18: inflammatory markers or mediators of hypertension?Probenecid blocks human P2X7 receptor-induced dye uptake via a pannexin-1 independent mechanism.P2X7R is involved in the progression of atherosclerosis by promoting NLRP3 inflammasome activation P2X7 receptor modulates inflammatory and functional pulmonary changes induced by silica.ATP release and purinergic signaling in NLRP3 inflammasome activation Extracellular ATP and other nucleotides-ubiquitous triggers of intercellular messenger release.Ion efflux and influenza infection trigger NLRP3 inflammasome signaling in human dendritic cells Clofazimine Biocrystal Accumulation in Macrophages Upregulates Interleukin 1 Receptor Antagonist Production To Induce a Systemic Anti-Inflammatory State Unsaturated fatty acids prevent activation of NLRP3 inflammasome in human monocytes/macrophages.The role of NLRP3 and AIM2 in inflammasome activation during Brucella abortus infection.Human Scavenger Receptor A1-Mediated Inflammatory Response to Silica Particle Exposure Is Size Specific.The NLRP3 inflammasome in Alzheimer's disease.Bioreactivity of the crystalline silica polymorphs, quartz and cristobalite, and implications for occupational exposure limits (OELs).Canonical and non-canonical effects of the NLRP3 inflammasome in kidney inflammation and fibrosis.The NLRP3 inflammasome: role in airway inflammation.Molecular pathways of pannexin1-mediated neurotoxicity.Do inflammatory pathways drive melanomagenesis?Role of connexins and pannexins in cardiovascular physiology.The inflammasome and danger molecule signaling: at the crossroads of inflammation and pathogen persistence in the oral cavity.Proteomics approach to understand reduced clearance of mycobacteria and high viral titers during HIV-mycobacteria co-infection.Pannexin1 as mediator of inflammation and cell death.Role of the Immune System in Hypertension.

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P2860

ATP release and purinergic signaling: a common pathway for particle-mediated inflammasome activation

http://www.wikidata.org/entity/Q36347237

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Cell Death and Disease

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P2860

Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica

Gout-associated uric acid crystals activate the NALP3 inflammasome

Pannexin membrane channels are mechanosensitive conduits for ATP

Cryopyrin activates the inflammasome in response to toxins and ATP

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

The NALP3 inflammasome is involved in the innate immune response to amyloid-beta

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

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10.1038/CDDIS.2012.144

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3

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Bernhard Ryffel

Isabelle Couillin

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