CRASH-3 - tranexamic acid for the treatment of significant traumatic brain injury: study protocol for an international randomized, double-blind, placebo-controlled trial - Wikidata - awgldk - TriplyDB

CRASH-3 - tranexamic acid for the treatment of significant traumatic brain injury: study protocol for an international randomized, double-blind, placebo-controlled trial

CRASH-3 - tranexamic acid for the treatment of significant traumatic brain injury: study protocol for an international randomized, double-blind, placebo-controlled trial

http://www.wikidata.org/entity/Q36347953

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Antifibrinolytic drugs for acute traumatic injury Antifibrinolytic drugs for acute traumatic injury.Neuroprotective strategies for traumatic brain injury: improving clinical translation Tranexamic acid for treatment and prophylaxis of bleeding and hyperfibrinolysis.Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial Tranexamic acid in pediatric trauma: why not?A nested mechanistic sub-study into the effect of tranexamic acid versus placebo on intracranial haemorrhage and cerebral ischaemia in isolated traumatic brain injury: study protocol for a randomised controlled trial (CRASH-3 Trial Intracranial Blee Advances in the understanding of trauma-induced coagulopathy Tranexamic acid for traumatic brain injury: a systematic review and meta-analysis Investigational agents for treatment of traumatic brain injury Pharmacological adjuncts to stop bleeding: options and effectiveness.Research studies that have influenced practice of neuroanesthesiology in recent years: A literature review.Tranexamic acid in bleeding trauma patients: an exploration of benefits and harms.The effect of tranexamic acid in traumatic brain injury: A randomized controlled trial.Bleeding management for pediatric craniotomies and craniofacial surgery.State of the art: massive transfusion.Review of Thromboelastography in Neurocritical Care.Challenges Enrolling Children Into Traumatic Brain Injury Trials: An Observational Study.Effectiveness of early administration of tranexamic acid in patients with severe trauma.Medical Management of the Severe Traumatic Brain Injury Patient.Effect sizes in ongoing randomized controlled critical care trials.Tranexamic Acid in Chronic Subdural Hematomas (TRACS): study protocol for a randomized controlled trial.Disseminated intravascular coagulation with increased fibrinolysis during the early phase of isolated traumatic brain injury.Age-related differences in fibrinolytic parameters in patients with acute traumatic brain injury Trauma research 2012.Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe haemorrhage: a meta-analysis of individual patient-level data from 40 138 bleeding patients.Fibrinolysis in trauma: a review.Intravenous tranexamic acid for hyperacute primary intracerebral hemorrhage: Protocol for a randomized, placebo-controlled trial.Development of a Prehospital Tranexamic Acid Administration Protocol.Acute Management of Traumatic Brain Injury.Post-partum haemorrhage and tranexamic acid: a global issue.The effectiveness and safety of antifibrinolytics in patients with acute intracranial haemorrhage: statistical analysis plan for an individual patient data meta-analysis.Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage (TICH-2): an international randomised, placebo-controlled, phase 3 superiority trial.Tranexamic acid for significant traumatic brain injury (The CRASH-3 trial): Statistical analysis plan for an international, randomised, double-blind, placebo-controlled trial Treatment of intracerebral haemorrhage with tranexamic acid – A review of current evidence and ongoing trials New Advances in the Care of the Hemorrhaging Patient

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CRASH-3 - tranexamic acid for the treatment of significant traumatic brain injury: study protocol for an international randomized, double-blind, placebo-controlled trial

http://www.wikidata.org/entity/Q36347953

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CRASH-3 Collaborators

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Edward O Komolafe

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Ian Roberts

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Jorge H Mejía-Mantilla

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Pablo Perel

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Yashbir Dewan

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Cost-effectiveness analysis of administering tranexamic acid to bleeding trauma patients using evidence from the CRASH-2 trial

Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion

Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples

Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial

Intracranial bleeding in patients with traumatic brain injury: a prognostic study

Equipoise and the ethics of clinical research.

Final results of MRC CRASH, a randomised placebo-controlled trial of intravenous corticosteroid in adults with head injury-outcomes at 6 months.

Effect of tranexamic acid in traumatic brain injury: a nested randomised, placebo controlled trial (CRASH-2 Intracranial Bleeding Study).

The epidemiology of traumatic brain injury: a review.

Coagulation disorders after traumatic brain injury.

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Haleema Shakur-Still

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traumatic brain injury

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