Human molecular genetic and functional studies identify TRIM63, encoding Muscle RING Finger Protein 1, as a novel gene for human hypertrophic cardiomyopathy.
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Targeting the ubiquitin-proteasome system in heart disease: the basis for new therapeutic strategiesComparative Analysis of Muscle Transcriptome between Pig Genotypes Identifies Genes and Regulatory Mechanisms Associated to Growth, Fatness and MetabolismA substitution mutation in cardiac ubiquitin ligase, FBXO32, is associated with an autosomal recessive form of dilated cardiomyopathyPrenatal Exposure to a Maternal High-Fat Diet Affects Histone Modification of Cardiometabolic Genes in Newborn Rats.Muscle-specific RING finger 1 negatively regulates pathological cardiac hypertrophy through downregulation of calcineurin A.Regulation of large conductance Ca2+-activated K+ (BK) channel β1 subunit expression by muscle RING finger protein 1 in diabetic vessels.Sequencing your genome: what does it mean?Heart Failure and MEF2 Transcriptome Dynamics in Response to β-Blockers.Rare variants in genes encoding MuRF1 and MuRF2 are modifiers of hypertrophic cardiomyopathy.The E3 ubiquitin ligase TRIM62 and inflammation-induced skeletal muscle atrophy.Examining rare and low-frequency genetic variants previously associated with lone or familial forms of atrial fibrillation in an electronic medical record system: a cautionary note.IMP 2.0: a multi-species functional genomics portal for integration, visualization and prediction of protein functions and networks.COP9 signalosome controls the degradation of cytosolic misfolded proteins and protects against cardiac proteotoxicity.[Diagnostics in human genetics : Integration of phenotypic and genomic data].Molecular genetic response to varied wavelengths of light in Xiphophorus maculatus skinTRIM24 protein promotes and TRIM32 protein inhibits cardiomyocyte hypertrophy via regulation of dysbindin protein levels.Clinical applications of molecular genetic discoveries.Pathogenesis of hypertrophic cardiomyopathy caused by myozenin 2 mutations is independent of calcineurin activityFenofibrate unexpectedly induces cardiac hypertrophy in mice lacking MuRF1.Ubiquitin receptors and protein quality controlCardiac Fibro-Adipocyte Progenitors Express Desmosome Proteins and Preferentially Differentiate to Adipocytes Upon Deletion of the Desmoplakin Gene.Causality in genetics: the gradient of genetic effects and back to Koch's postulates of causality.Mouse genome-wide association study identifies polymorphisms on chromosomes 4, 11, and 15 for age-related cardiac fibrosis.The hippo pathway is activated and is a causal mechanism for adipogenesis in arrhythmogenic cardiomyopathy.Muscle RING finger-1 attenuates IGF-I-dependent cardiomyocyte hypertrophy by inhibiting JNK signaling.Mammalian target of rapamycin signaling in cardiac physiology and disease.The role of ubiquitin ligases in cardiac disease.Molecular basis for the fold organization and sarcomeric targeting of the muscle atrogin MuRF1Human genotype-phenotype databases: aims, challenges and opportunities.Ubiquitin and ubiquitin-like proteins in cardiac disease and protection.Proteasome dysfunction in cardiomyopathies.Genetics and Genomics of Single-Gene Cardiovascular Diseases: Common Hereditary Cardiomyopathies as Prototypes of Single-Gene Disorders.TRIM proteins and diseases.The Calcineurin-FoxO-MuRF1 signaling pathway regulates myofibril integrity in cardiomyocytes.Genetically induced moderate inhibition of 20S proteasomes in cardiomyocytes facilitates heart failure in mice during systolic overload.Hypertrophic Cardiomyopathy: Genetics, Pathogenesis, Clinical Manifestations, Diagnosis, and Therapy.Non-syndromic cardiac progeria in a patient with the rare pathogenic p.Asp300Asn variant in the LMNA gene.Phenotypic screening with human iPS cell-derived cardiomyocytes: HTS-compatible assays for interrogating cardiac hypertrophy.Small-molecule inhibition of MuRF1 attenuates skeletal muscle atrophy and dysfunction in cardiac cachexia.Conserved structural and functional aspects of the tripartite motif gene family point towards therapeutic applications in multiple diseases.
P2860
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P2860
Human molecular genetic and functional studies identify TRIM63, encoding Muscle RING Finger Protein 1, as a novel gene for human hypertrophic cardiomyopathy.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Human molecular genetic and fu ...... n hypertrophic cardiomyopathy.
@ast
Human molecular genetic and fu ...... n hypertrophic cardiomyopathy.
@en
type
label
Human molecular genetic and fu ...... n hypertrophic cardiomyopathy.
@ast
Human molecular genetic and fu ...... n hypertrophic cardiomyopathy.
@en
prefLabel
Human molecular genetic and fu ...... n hypertrophic cardiomyopathy.
@ast
Human molecular genetic and fu ...... n hypertrophic cardiomyopathy.
@en
P2093
P2860
P1433
P1476
Human molecular genetic and fu ...... an hypertrophic cardiomyopathy
@en
P2093
Ali J Marian
Grazyna Czernuszewicz
James T Willerson
Jianping Jin
Suet Nee Chen
P2860
P304
P356
10.1161/CIRCRESAHA.112.270207
P577
2012-07-19T00:00:00Z