Targeting NAD+ salvage pathway induces autophagy in multiple myeloma cells via mTORC1 and extracellular signal-regulated kinase (ERK1/2) inhibition. - Wikidata - awgldk - TriplyDB

Targeting NAD+ salvage pathway induces autophagy in multiple myeloma cells via mTORC1 and extracellular signal-regulated kinase (ERK1/2) inhibition.

Targeting NAD+ salvage pathway induces autophagy in multiple myeloma cells via mTORC1 and extracellular signal-regulated kinase (ERK1/2) inhibition.

http://www.wikidata.org/entity/Q36352540

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Endoplasmic reticulum stress-mediated pathways to both apoptosis and autophagy: Significance for melanoma treatment Nicotinamide phosphoribosyl transferase (Nampt) is a target of microRNA-26b in colorectal cancer cells Identification of novel pathogenic copy number aberrations in multiple myeloma: the Malaysian context FK866 attenuates acute hepatic failure through c-jun-N-terminal kinase (JNK)-dependent autophagy A critical role of autophagy in antileukemia/lymphoma effects of APO866, an inhibitor of NAD biosynthesis.Signals from the lysosome: a control centre for cellular clearance and energy metabolism.EIF2A-dependent translational arrest protects leukemia cells from the energetic stress induced by NAMPT inhibition Nicotinamide phosphoribosyltransferase can affect metastatic activity and cell adhesive functions by regulating integrins in breast cancer.The function of nicotinamide phosphoribosyltransferase in the heart.Nicotinamide phosphoribosyltransferase promotes epithelial-to-mesenchymal transition as a soluble factor independent of its enzymatic activity Depletion of the central metabolite NAD leads to oncosis-mediated cell death.Comparative Metabolomic Profiling Reveals That Dysregulated Glycolysis Stemming from Lack of Salvage NAD+ Biosynthesis Impairs Reproductive Development in Caenorhabditis elegans NAMPT/PBEF1 enzymatic activity is indispensable for myeloma cell growth and osteoclast activity.Target therapy of multiple myeloma by PTX-NPs and ABCG2 antibody in a mouse xenograft model Coordination of autophagy with other cellular activities AMPK activation protects cells from oxidative stress-induced senescence via autophagic flux restoration and intracellular NAD(+) elevation.Intracellular NAD⁺ depletion enhances bortezomib-induced anti-myeloma activity.Antiestrogen-binding site ligands induce autophagy in myeloma cells that proceeds through alteration of cholesterol metabolism CD73 protein as a source of extracellular precursors for sustained NAD+ biosynthesis in FK866-treated tumor cells Dependence of tumor cell lines and patient-derived tumors on the NAD salvage pathway renders them sensitive to NAMPT inhibition with GNE-618 Small interfering RNA-mediated silencing of nicotinamide phosphoribosyltransferase (NAMPT) and lysosomal trafficking regulator (LYST) induce growth inhibition and apoptosis in human multiple myeloma cells: A preliminary study.TFEB-mediated increase in peripheral lysosomes regulates store-operated calcium entry Targeting metabolic scavenging in pancreatic cancer.A pancreatic ductal adenocarcinoma subpopulation is sensitive to FK866, an inhibitor of NAMPT.Autophagy in blood cancers: biological role and therapeutic implications.Cell death by autophagy: emerging molecular mechanisms and implications for cancer therapy.EWS-FLI1 confers exquisite sensitivity to NAMPT inhibition in Ewing sarcoma cells.RNA interference for multiple myeloma therapy: targeting signal transduction pathways.Physiological and pathophysiological roles of NAMPT and NAD metabolism.The NAD(+) salvage pathway modulates cancer cell viability via p73.Nicotinamide phosphoribosyltransferase (Nampt) in carcinogenesis: new clinical opportunities.Transcription factor EB: from master coordinator of lysosomal pathways to candidate therapeutic target in degenerative storage diseases.Intracellular nicotinamide adenine dinucleotide promotes TNF-induced necroptosis in a sirtuin-dependent manner.Cell adhesion down-regulates the expression of vacuolar protein sorting 4B (VPS4B) and contributes to drug resistance in multiple myeloma cells.Insulin-Like Growth Factor-1 Modulates Polycomb Cbx8 Expression and Inhibits Colon Cancer Cell Apoptosis.The anti-lymphoma activity of APO866, an inhibitor of nicotinamide adenine dinucleotide biosynthesis, is potentialized when used in combination with anti-CD20 antibody.Autophagic homeostasis is required for the pluripotency of cancer stem cells.Regulation and Function of Extracellular Nicotinamide Phosphoribosyltransferase/Visfatin.Nicotinamide phosphoribosyltransferase (NAMPT) activity is essential for survival of resting lymphocytes.Induction of apoptosis and autophagy via sirtuin1- and PI3K/Akt/mTOR-mediated pathways by plumbagin in human prostate cancer cells.

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Targeting NAD+ salvage pathway induces autophagy in multiple myeloma cells via mTORC1 and extracellular signal-regulated kinase (ERK1/2) inhibition.

http://www.wikidata.org/entity/Q36352540

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2012 nî lūn-bûn

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2012年の論文

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年學術文章

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2012年學術文章

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2012年學術文章

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Targeting NAD+ salvage pathway ...... ed kinase (ERK1/2) inhibition.

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Targeting NAD+ salvage pathway ...... ed kinase (ERK1/2) inhibition.

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Targeting NAD+ salvage pathway ...... ed kinase (ERK1/2) inhibition.

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Targeting NAD+ salvage pathway ...... ed kinase (ERK1/2) inhibition.

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Targeting NAD+ salvage pathway ...... ed kinase (ERK1/2) inhibition.

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Targeting NAD+ salvage pathway ...... ed kinase (ERK1/2) inhibition.

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Targeting NAD+ salvage pathway ...... ted kinase (ERK1/2) inhibition

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Alessio Nencioni

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Antonia Cagnetta

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Dharminder Chauhan

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Francesca Cottini

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Franco Patrone

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Jana Jakubikova

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Marco Gobbi

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Mariateresa Fulciniti

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Nikhil Munshi

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Sun-Young Kong

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P2860

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

On the Origin of Cancer Cells

Enzymology of NAD+ homeostasis in man.

New functions of a long-known molecule. Emerging roles of NAD in cellular signaling

Synergistic interactions between HDAC and sirtuin inhibitors in human leukemia cells

The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells

Methods in mammalian autophagy research

Development by self-digestion: molecular mechanisms and biological functions of autophagy

Autophagy: from phenomenology to molecular understanding in less than a decade

FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells

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3519-3529

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scholarly article

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10.1182/BLOOD-2012-03-416776

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17

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120

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Teresa Calimeri

Kenneth C Anderson

Paul G Richardson

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2012-09-05T00:00:00Z

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230811227

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