Single-cell genetic analysis of ductal carcinoma in situ and invasive breast cancer reveals enormous tumor heterogeneity yet conserved genomic imbalances and gain of MYC during progression.
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Genomic Changes in Normal Breast Tissue in Women at Normal Risk or at High Risk for Breast CancerAtypical Rho GTPases of the RhoBTB Subfamily: Roles in Vesicle Trafficking and TumorigenesisBreast cancer intra-tumor heterogeneityInvestigating intratumour heterogeneity by single-cell sequencingAppraisal of the technologies and review of the genomic landscape of ductal carcinoma in situ of the breastPhylogenetic analysis of multiprobe fluorescence in situ hybridization data from tumor cell populations.A simplicial complex-based approach to unmixing tumor progression data.Classifying the Progression of Ductal Carcinoma from Single-Cell Sampled Data via Integer Linear Programming: A Case Study.Medoidshift clustering applied to genomic bulk tumor data.PI3K pathway activation in high-grade ductal carcinoma in situ--implications for progression to invasive breast carcinoma.Clinicopathologic and prognostic significance of c-MYC copy number gain in lung adenocarcinomas.Algorithms to model single gene, single chromosome, and whole genome copy number changes jointly in tumor phylogenetics.Single-cell genetic analysis reveals insights into clonal development of prostate cancers and indicates loss of PTEN as a marker of poor prognosis.Tumour heterogeneity in the clinic.Induction of entosis by epithelial cadherin expressionCKAP2 ensures chromosomal stability by maintaining the integrity of microtubule nucleation sites.CENP-A nucleosomes localize to transcription factor hotspots and subtelomeric sites in human cancer cellsInferring models of multiscale copy number evolution for single-tumor phylogenetics.Mutational Profiling Can Establish Clonal or Independent Origin in Synchronous Bilateral Breast and Other Tumors.FISHtrees 3.0: Tumor Phylogenetics Using a Ploidy ProbePhylogenetic analysis of multiple FISH markers in oral tongue squamous cell carcinoma suggests that a diverse distribution of copy number changes is associated with poor prognosis.Three-dimensional modelling identifies novel genetic dependencies associated with breast cancer progression in the isogenic MCF10 modelCyclin dependent kinase-9 mediated transcriptional de-regulation of cMYC as a critical determinant of endocrine-therapy resistance in breast cancers.Progression from ductal carcinoma in situ to invasive breast cancer: revisited.Clinical management of breast cancer heterogeneity.Molecular Profiling and Significance of Circulating Tumor Cell Based Genetic Signatures.Ductal carcinoma in situ - update on risk assessment and management.Catalog of genetic progression of human cancers: breast cancer.Clinical and molecular relevance of mutant-allele tumor heterogeneity in breast cancer.The Cellular Origin and Evolution of Breast Cancer.The evolution of tumour phylogenetics: principles and practice.Automated deconvolution of structured mixtures from heterogeneous tumor genomic data.Multiclonal Invasion in Breast Tumors Identified by Topographic Single Cell Sequencing.An Improved Binary Differential Evolution Algorithm to Infer Tumor Phylogenetic Trees.Bivalent Epigenetic Control of Oncofetal Gene Expression in Cancer.Intratumor heterogeneity predicts metastasis of triple-negative breast cancer.Aneuploidy, TP53 mutation, and amplification of MYC correlate with increased intratumor heterogeneity and poor prognosis of breast cancer patients.The Evolution of Single Cell-derived Colorectal Cancer Cell Lines is Dominated by the Continued Selection of Tumor Specific Genomic Imbalances, Despite Random Chromosomal Instability.Levels of miR-126 and miR-218 are elevated in ductal carcinoma in situ (DCIS) and inhibit malignant potential of DCIS derived cells.
P2860
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P2860
Single-cell genetic analysis of ductal carcinoma in situ and invasive breast cancer reveals enormous tumor heterogeneity yet conserved genomic imbalances and gain of MYC during progression.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Single-cell genetic analysis o ...... ain of MYC during progression.
@ast
Single-cell genetic analysis o ...... ain of MYC during progression.
@en
type
label
Single-cell genetic analysis o ...... ain of MYC during progression.
@ast
Single-cell genetic analysis o ...... ain of MYC during progression.
@en
prefLabel
Single-cell genetic analysis o ...... ain of MYC during progression.
@ast
Single-cell genetic analysis o ...... ain of MYC during progression.
@en
P2093
P2860
P1476
Single-cell genetic analysis o ...... gain of MYC during progression
@en
P2093
Alejandro A Schäffer
Amanda Bradley
Clarymar Ortiz-Melendez
Kerstin Heselmeyer-Haddad
Lissa Y Berroa Garcia
Peter W Soballe
Rebecca Christensen
Salim A Chowdhury
Sheila A Prindiville
Thomas Ried
P2860
P304
P356
10.1016/J.AJPATH.2012.07.012
P407
P577
2012-10-08T00:00:00Z